A5102927909- Bone Tissue Engineering Materials
- RNA modifications and cancer
- Advancements in Battery Materials
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Ferroptosis and cancer prognosis
- Advanced Battery Materials and Technologies
- Crystallization and Solubility Studies
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
- Advanced Battery Technologies Research
- X-ray Diffraction in Crystallography
- Electrospun Nanofibers in Biomedical Applications
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Mesenchymal stem cell research
- Smart Materials for Construction
- Cancer, Lipids, and Metabolism
- Periodontal Regeneration and Treatments
- RNA Research and Splicing
- Concrete Corrosion and Durability
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
Chengdu Medical College
2024
Wuhan University
2021-2024
Tongren Hospital
2023-2024
Sichuan University
2022-2024
Wuhan Third Hospital
2024
The People's Hospital of Guangxi Zhuang Autonomous Region
2023
Southern Medical University
2013-2022
Nanfang Hospital
2015-2022
Zhejiang University
2016-2018
East China University of Science and Technology
2016
Copper (Cu) is an essential trace element whose serum levels have been reported to act as effective indicator of the efficacy radiotherapy. However, little known about role Cu in In this study we aimed determine and investigate precise mechanism by which or Cu-related proteins regulate radiosensitivity hepatocellular carcinoma (HCC).The expression function copper metabolism MURR1 domain 10 (COMMD10) were assessed via a detection assay, immunostaining, real-time PCR, western blot, radiation...
Abstract The critical issue that hinders the translation of nanomaterials from basic research to clinical trials is their potential toxicity caused by long‐term body retention. It still a huge challenge integrate renal‐clearable and theranostic properties into one nanomedicine, especially exploring with optical absorption in second near‐infrared light (NIR II) biowindow deep penetration less tissue scattering. Here, ultrasmall polypyrrole (PPy, ≈2 nm)‐based agents via facile green one‐step...
Irradiation has emerged as a valid tool for nasopharyngeal carcinoma (NPC) in situ treatment; however, NPC derived from tissues treated with irradiation is main cause cancer-related death. The purpose of this study to uncover the underlying mechanism regarding tumor growth after and provided potential therapeutic strategy.Fibroblasts were extracted fresh tissue normal mucosa. Immunohistochemistry was conducted measure expression α-SMA FAP. Cytokines detected by protein array chip identified...
Electrospun composite nanofiber scaffolds are well known for their bone and tissue regeneration applications. This research is focused on the development of PVP PVA enriched with hydroxyapatite (HA) nanoparticles alendronate (ALN) using electrospinning technique. The developed were investigated physicochemical as potential. results obtained from particle size, zeta potential, SEM EDX analysis HA confirmed successful fabrication. Further, verified nanofiber's diameters within 200-250 nm,...
The Copper Metabolism MURR1 (COMM) domain family has been reported to play important roles in tumorigenesis. As a prototype for the COMMD family, expression pattern and biological function of COMMD6 human tumours remain unknown.COMMD6 BALB/c mice tissues was examined using real-time PCR immunohistochemistry. Kaplan-Meier analysis applied evaluate prognosis tumours. Competing endogenous RNA (ceRNA) transcriptional regulation network were constructed based on differentially expressed mRNAs,...
IFI44 (interferon-induced protein 44), containing a guanosine-5'-triphosphate (GTP) binding domain, was reported to play significant role in immune response autoimmune disease. However, its roles involved cancers remain unclear. Here, we detected the expression of TCGA Pan-cancer and generally explored influence on infiltration tumor microenvironment. The results displayed that mainly located cytoplasm, overexpressed head neck squamous cell carcinoma (HNSC) samples compared with normal...
Pulmonary surfactant protein A1 (SFTPA1) is a member of the C-type lectin subfamily that plays critical role in maintaining lung tissue homeostasis and innate immune response. SFTPA1 disruption can cause several acute or chronic diseases, including cancer. However, little research has been performed to associate with cell infiltration response immunotherapy The findings our study describe expression profile multiple databases was validated BALB/c mice, human tumor tissues, paired normal...
Abstract Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. Currently, there limited knowledge dysregulation cellular proliferation and apoptosis that contribute to malignant phenotype in HCC. Copper metabolism gene MURR1 domain 10 (COMMD10) initially identified as a suppressor pathogenesis HCC our observations. Here we aimed explore its function prognostic value progression Methods Functional experiments were performed role COMMD10 The...
The micro–nano-structured FePO4·2H2O was prepared from mixed solution of FeSO4 oxidized in diluted H3PO4 with H2O2 and NaOH the turbulent flow cycle state at 90 °C. resulting products were characterized by thermogravimetric analysis (TGA), scanning electron microscopy (SEM), transmission (TEM). Constant current charge/discharge tests adopted to investigate electrochemical performance rate capability (from 0.1C 5C) carbon-coated LiFePO4 composite materials FePO4. deliver a high specific...
Abstract Background In recent years, natural bone extracellular matrix (ECM)-inspired materials have found widespread application as scaffolds for tissue engineering. However, the challenge of creating that mimic ECM’s mechanical strength and hierarchical nano-micro-macro structures remains. The purposes this study were to introduce an innovative ECM-inspired scaffold integrates a 3D-printed framework with hydroxyapatite (HAp) mineralized graphene oxide-collagen (GO-Col) microscaffolds find...
CHST4 plays an important role in lymphocyte homing and is abnormally expressed several cancer types; however, its precise function tumor development progression unknown. Here we confirm that aberrantly various subtypes. In particular, found expression was downregulated hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) tumors compared to paired normal tissue. We also showed overexpression inhibited the proliferation metastasis of HCC cells vitro. Clinically, identified as...
Single ionizing radiation at a tolerable dose is ineffectual in eliminating malignancies but readily generates harmful effects on surrounding normal tissues. Herein, we intelligently fabricated novel wolfram-doped polypyrrole (WPPy) through simple oxidative polymerization method with WCl6 as an oxidizing catalyst, which possessed good biocompatibility, high photothermal conversion, and intensive radiosensitivity capacities to concurrently serve reagent radiosensitizer for...
Abstract Background Spectrin repeat containing nuclear envelope family member 3 (SYNE3) encodes an essential component of the linker cytoskeleton and nucleoskeleton (LINC) complex, namely nesprin-3. In a tumor, invasiveness metastasis rely on integrity LINC while role SYNE3/nesprin-3 in cancer is rarely studied. Methods Here, we explored expression pattern, prognostic value, related mechanisms SYNE3 through both experimental bioinformatic methods. We first detected BALB/c mice, normal human...