A5100461747- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Fibroblast Growth Factor Research
- Natural Compounds in Disease Treatment
- Lipid metabolism and biosynthesis
- Kruppel-like factors research
- RNA Research and Splicing
- Phytochemical Studies and Bioactivities
- Microtubule and mitosis dynamics
- Hippo pathway signaling and YAP/TAZ
- Nanoparticle-Based Drug Delivery
- Physiological and biochemical adaptations
- Cancer Research and Treatments
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Natural product bioactivities and synthesis
- Cancer-related gene regulation
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Proteoglycans and glycosaminoglycans research
- Cancer, Lipids, and Metabolism
- High Altitude and Hypoxia
- Peroxisome Proliferator-Activated Receptors
- Ginseng Biological Effects and Applications
- RNA modifications and cancer
Chengdu Medical College
2024
Hubei University of Chinese Medicine
2023
First Affiliated Hospital of Zhengzhou University
2022
Chinese Academy of Fishery Sciences
2021
Stanford University
2019
VA Palo Alto Health Care System
2019
University of Maryland, Baltimore
2016-2019
Hebei Medical University
2018
Second Hospital of Hebei Medical University
2018
Second Military Medical University
2012
Hypoxia-inducible factors (HIFs), especially HIF-1α and HIF-2α, are key mediators of the adaptive response to hypoxic stress play essential roles in maintaining lung homeostasis. Human animal genetics studies confirm that abnormal HIF correlates with pulmonary vascular pathology chronic diseases, but it remains unclear whether endothelial cell production is for microvascular health. The large airway has an ideal circulatory bed evaluating histological changes physiology genetically modified rodents.
Drug resistance is a major factor for the limited efficacy of chemotherapy in gastric cancer treatment. Hypoxia-inducible factor-1α (HIF-1α), central transcriptional hypoxia, suggested to participate resistance. Here, we identified hypoxia-mimic (cobalt chloride) sensitive cell line BGC-823 explore whether diosgenin, an aglycone steroidal saponins, can inhibit invasion and survival solid tumor hypoxic mimic microenvironment. We have shown that diosgenin potent candidate decreasing ability...