A5077199281- Cancer, Lipids, and Metabolism
- Computational Drug Discovery Methods
- Plant-based Medicinal Research
- Ferroptosis and cancer prognosis
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Plant-derived Lignans Synthesis and Bioactivity
- Pharmacological Effects of Natural Compounds
- Inflammatory Bowel Disease
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipid metabolism and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Genomics, phytochemicals, and oxidative stress
- Renal Diseases and Glomerulopathies
- Flavonoids in Medical Research
- Gout, Hyperuricemia, Uric Acid
- Ginseng Biological Effects and Applications
- Atherosclerosis and Cardiovascular Diseases
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- Berberine and alkaloids research
- Vitamin C and Antioxidants Research
- Platelet Disorders and Treatments
Hubei University of Chinese Medicine
2018-2023
Huangshan University
2021
Hubei Provincial Hospital of Traditional Chinese Medicine
2021
Compound sophorae decoction, a Chinese medicinal formulae composed of six herbs, is effective for the clinical treatment ulcerative colitis (UC). Some its monomers had been proven to have suppressive effect on UC models. The aim this study further explore mechanism whether compound decoction ameliorates dextran sodium sulfate (DSS)-induced mice by regulating balance between T helper (Th) 17 and regulatory (Treg) cells.Experimental model UC, established drinking water with DSS, was treated...
Colorectal cancer (CRC) is one of the most deadly malignant tumors, which seriously threatens human health. Ferroptosis, a new type iron-dependent cell regulatory necrosis. Inducing ferroptosis tumor cells regarded as potential treatment strategy. However, prognostic value ferroptosis-related genes in CRC remains to be further elucidated. Gallic acid, widely used chemical, pharmaceutical, and food fields, dietary supplement with prescription significance. In this study, mRNA expression...
Glycolysis can improve the tolerance of tissue cells to hypoxia, and its intermediates provide raw materials for synthesis metabolism tumor cells. If it inhibit activity glycolysis-related enzymes control energy tumor, be targeted treatment malignant tumor. The target proteins phosphoglycerate kinase 2 (PGK2), glycerol-3-phosphate dehydrogenase (GPD2) glucose-6-phosphate isomerase (GPI) were screened by combining transcriptome, proteomics reverse docking. We detected binding constant active...
The high expression of fatty acid synthase (FAS) in tumor cells is consistent with their elevated requirement for acids cell membrane synthesis and energy supply to support almost unlimited proliferation. levels FAS are related proliferation, invasion, metastasis. This study investigated the possible bioactive ingredients (fraxin, esculetin, scopolin et al.) Cortex Fraxini effects on interaction between specific proteins. We used microscale thermophoresis (MST) show that our target protein,...
Coronavirus disease (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a highly infectious viral disease. Clinical observations have shown that Qing-Fei-Da-Yuan (QFDY) granules good anti-COVID-19 effects, but underlying molecular mechanisms are unclear. In this study, we explored potential mechanism of QFDY with regard to its effect. We first screened active chemical constituents based on pharmacodynamic activity parameters, followed screening...
Aim of study: The main objective this study was to investigate the antithrombotic and antiplatelet effect extract from Rostellularia procumbenss (L.) Nees understand mechanisms by which it exerts its mechanisms. Materials methods: effective parts (RPE) were isolated using D101 macroporous adsorption resin potential active ingredients (JAC) preparative liquid-phase method. lactate dehydrogenase kit used determine toxicity RPE JAC platelets. antiadhesion on platelets observed fluorescence...
Mesangial proliferative glomerulonephritis (MsPGN) is characterized by mesangial cell proliferation, inflammation, and extracellular matrix deposition in the area, which develops into glomerulosclerosis contributes to end-stage renal disease. Justicidin B a bioactive compound isolated from Justicia procumbens L., traditional herbal remedy that reduces proteinuria nephritis. However, mechanism of B’s therapeutic effect on MsPGN remains unclear. This study was aimed explore positive MsPGN. The...
Shu-Feng-Jie-Du Capsules (SFJDCs) have been clinically proven to a good therapeutic effect on COVID-19 in China. This study aimed analyze the common mechanisms of SFJDC treatment severe acute respiratory syndrome (SARS), Middle East (MERS), and via network pharmacology molecular docking. We further explored potential application value coronavirus infection. All components were collected from Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform. The viral associated...
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), is often accompanied injury to pulmonary function and fibrosis. Feiluoning (FLN) a new Chinese medicine prescription which available for the treatment of critical convalescence COVID-19 patients. FLN also has positive effect on We explored potential mechanism FLN’s convalescent COVID-19. According pharmacodynamic activity parameters, we screened active chemical constituents comparing...

 Purpose: To investigate the bio-active components and potential mechanism of prescription remedy, Han-Shi blocking lung, with network pharmacology a view to expanding its application.
 Methods: Chemical were first collected from Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform (TCMSP). Pharmmapper database GeneCards used predict targets related active COVID-19. Using DAVIDE KOBAS 3.0 databases, Gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG)...
Ethnopharmacological relevance: Justicia procumbens L. is a traditional Chinese medicine, first recorded in 'Shen Nong's Herbal Classic', for the treatment of lumbar pain and fever. As widely distributed herb, it has also been documented India, Nepal, Malaysia. In 'Tang Materia Medica', famous medicinal book Tang Dynasty ancient China, was used to treat diseases associated with blood stasis. Blood stasis syndrome closely related thrombus formation platelet aggregation. Although few compounds...