A5100341986- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Computational Drug Discovery Methods
- Plant-based Medicinal Research
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Perovskite Materials and Applications
- Flavonoids in Medical Research
- RNA modifications and cancer
- Ginseng Biological Effects and Applications
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Plant-derived Lignans Synthesis and Bioactivity
- Head and Neck Cancer Studies
- Parasites and Host Interactions
- Drug-Induced Hepatotoxicity and Protection
- Ferroptosis and cancer prognosis
- Traditional Chinese Medicine Studies
- Platelet Disorders and Treatments
- Berberine and alkaloids research
- Pediatric health and respiratory diseases
- Phytochemistry and Biological Activities
- Plant Toxicity and Pharmacological Properties
Hubei University of Chinese Medicine
2016-2025
Hubei Zhongshan Hospital
2025
Wuhan University
2025
Jingdezhen Ceramic Institute
2023-2024
Peking University
2016-2023
Peking University Cancer Hospital
2023
Capital Institute of Pediatrics
2023
Sichuan University
2010-2023
West China Hospital of Sichuan University
2022-2023
Shanghai Innovative Research Center of Traditional Chinese Medicine
2019-2022
Several long non-coding RNA (lncRNA) might be correlated with the prognosis of colorectal cancer (CRC) and serve as a diagnostic prognostic biomarker. However, exact expression pattern small nucleolar host gene 12 (SNHG12) in its clinical significance remains unclear. The level SNHG12 was detected by qRT-PCR CRC tissues cells. MTT assay colony formation were performed to examine cell proliferation cells transfected pcDNA-SNHG12 or si-SNHG12. Flow cytometry technology used detect cycle...
Colorectal cancer (CRC) is one of the most deadly malignant tumors, which seriously threatens human health. Ferroptosis, a new type iron-dependent cell regulatory necrosis. Inducing ferroptosis tumor cells regarded as potential treatment strategy. However, prognostic value ferroptosis-related genes in CRC remains to be further elucidated. Gallic acid, widely used chemical, pharmaceutical, and food fields, dietary supplement with prescription significance. In this study, mRNA expression...
Breast cancer (BC) is one of the most common malignant tumors with highest mortality in world. Modern pharmacological studies have shown that Syringin has an inhibitory effect on many tumors, but its anti-BC efficacy and mechanism are still unclear.First, was isolated from Acanthopanax senticosus (Rupr. & Maxim.) Harms (ASH) by systematic solvent extraction silica gel chromatography column. The plant name composed genus epithet, species additive words persons' who give name. Then, hub...
Magnolia grandiflora is an important medicinal, ornamental and horticultural plant species. The chloroplast (cp) genome of M. was sequenced using a 454 sequencing platform the structure compared with other related complete cp 159623 bp in length contained pair inverted repeats (IR) 26563 separated by large small single copy (LSC, SSC) regions 87757 18740 bp, respectively. A total 129 genes were successfully annotated, 18 which included introns. identity, number GC content similar to those...
Abstract Rubia cordifolia L. is widely used in Asia and its antihepatoma effect has been proved by vitro vivo experiments. However, there are few studies on specific mechanism. In the present study, network pharmacology method was to construct component/target/pathway molecular regulatory for of explore effective components potential The chemical were identified through literature databases, evaluated screened drug likeness pharmacokinetic characteristics (ADMET). targets active predicted...
Systemic lupus erythematosus (SLE) is a serious disorder of immune regulation characterized by overproduction autoantibodies, nephritis, CD4+ T cell aberrant activation, and complex-mediated inflammation. The chronic graft vs. host disease (cGVHD) mouse model well-established SLE. Quercitrin natural compound found in Tartary buckwheat with potential anti-inflammatory effect that used to treat heart vascular conditions. In our previous study, we determined quercitrin an immunosuppressant...
Glycolysis can improve the tolerance of tissue cells to hypoxia, and its intermediates provide raw materials for synthesis metabolism tumor cells. If it inhibit activity glycolysis-related enzymes control energy tumor, be targeted treatment malignant tumor. The target proteins phosphoglycerate kinase 2 (PGK2), glycerol-3-phosphate dehydrogenase (GPD2) glucose-6-phosphate isomerase (GPI) were screened by combining transcriptome, proteomics reverse docking. We detected binding constant active...
Objective To evaluate whether pretreatment serum hormone levels are a prognostic factor for prostatic cancer with bony metastasis under hormonal treatment. Patients and methods Between 1980 1994, 96 patients prostate were included an evaluation by retrospective review of their charts. All had received treatment after diagnosis metastatic carcinoma. Serum testosterone, luteinizing (LH), follicle‐stimulating (FSH) prolactin assessed before The divided into two groups according to response...
The aim of this study was to investigate whether bone marrow stem cells (MSCs) derived exosomes in rats could promote osteoblast proliferation and improve osteoporosis via inhibiting cell apoptosis.MSCs were isolated cultured, followed by the identification surface antigens flow cytometry. differentiation MSCs detected alizarin red staining oil staining. After extraction from ultracentrifugation, size distribution tunable resistive pulse sensing (TRPS). Specific MSCs-derived determined...
Isogarcinol (YDIS), a natural compound extracted from Garcinia mangostana L., has significant immunosuppressive effect on systemic lupus erythematosus and rheumatoid arthritis. This paper reports that it reduced imiquimod-induced psoriasis-like skin lesions in mice. It strongly attenuated the aberrant proliferation differentiation of keratinocytes. Moreover, expression genes involving interleukin-23 (IL-23)/T-helper 17 (Th17) axis was significantly inhibited dorsal YDIS-treated mice, as...
A simple and intuitive method for optimizing the chemical constituents of Coptis Chinensis Franch. is important to assess its quality clinical efficacy. An high performance liquid chromatography ultraviolet spectrophotometry was developed determination berberine hydrochloride, palmatine chloride, jatrorrhizine epiberberine, coptisine, columbamine magnoflorine in various tissues (i.e., phloem, xylem medulla) rizhome C. The transection rhizome from outside-in includes cork layer, cortex,...
There has been a large global outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), representing major public health issue. In China, combination therapy, including traditional Chinese medicine (TCM) as treatment for COVID-19 used widely. "Fei Yan No. 1" (QFDYG) is formula recommended the Hubei Government to treat COVID-19. A retrospective study 84 patients from Provincial Hospital TCM and Renmin Hanchuan was conducted explore clinical...