L. S. Chang

ORCID: 0009-0001-8442-8711
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About
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Research Areas
  • Testicular diseases and treatments
  • Sperm and Testicular Function
  • Kidney Stones and Urolithiasis Treatments
  • Bladder and Urothelial Cancer Treatments
  • Urological Disorders and Treatments
  • Urinary Bladder and Prostate Research
  • Prostate Cancer Treatment and Research
  • Prostate Cancer Diagnosis and Treatment
  • Hormonal and reproductive studies
  • Medical Imaging and Pathology Studies
  • Urinary and Genital Oncology Studies
  • Sarcoma Diagnosis and Treatment
  • Neuroblastoma Research and Treatments
  • Renal cell carcinoma treatment
  • Urologic and reproductive health conditions
  • Reproductive Biology and Fertility
  • Sexual Differentiation and Disorders
  • Ureteral procedures and complications
  • Sexual function and dysfunction studies
  • Abdominal Surgery and Complications
  • Minimally Invasive Surgical Techniques
  • Xenotransplantation and immune response
  • Congenital Diaphragmatic Hernia Studies
  • Glutathione Transferases and Polymorphisms
  • Connexins and lens biology

Yantaishan Hospital
2023

Yantai Academy of Agricultural Sciences
2023

Xi'an Jiaotong University
2013

National Yang Ming Chiao Tung University
1993-2007

Taipei Veterans General Hospital
1988-2007

National Yang Ming University Hospital
1993-2007

National Taipei University
2007

Institute of Clinical Research
2002

Jen-Ai Hospital
2000-2002

Taipei Municipal Jen-Ai Hospital
2002

BACKGROUND: To examine glutathione S-transferase M1 (GST M1) gene polymorphism and male infertility in Taiwanese patients with varicocele, 80 young varicocele (group 1), 62 subclinical 2) 60 normal males 3) were recruited this study. METHODS: GST null homozygous genotype [GST (–)] the occurrence of a 4977 bp deletion sperm mitochondrial DNA (mtDNA) determined by polymerase chain reaction. The 8-hydroxy-2′-deoxyguanosine (8-OHdG) content was measured high-performance liquid chromatography....

10.1093/humrep/17.3.718 article EN Human Reproduction 2002-03-01

Objective To evaluate whether pretreatment serum hormone levels are a prognostic factor for prostatic cancer with bony metastasis under hormonal treatment. Patients and methods Between 1980 1994, 96 patients prostate were included an evaluation by retrospective review of their charts. All had received treatment after diagnosis metastatic carcinoma. Serum testosterone, luteinizing (LH), follicle‐stimulating (FSH) prolactin assessed before The divided into two groups according to response...

10.1046/j.1464-410x.2002.02733.x article EN BJU International 2002-05-01

We reviewed 1055 patients with symptomatic urinary calculi treated by extracorporeal shock wave lithotripsy (ESWL) monotherapy to determine the long-term stone regrowth and recurrence rates as correlated pre-treatment burden, site multiplicity. Long-term follow-up (mean 75.8 months) was available in 94 patients, representing 106 renal units. The of defined reappearance on plain abdominal radiographs. regrowing larger than one-third original residual size. A stone-free rate 53% achieved....

10.1111/j.1464-410x.1993.tb16248.x article EN British Journal of Urology 1993-11-01

In order to investigate the effects of arterial beds on pressure waveforms in arteries, waves observed rat tail artery were resolved into their Fourier moduli before and during ligation left renal superior mesenteric artery. Consistently different patterns waveform changes seen occlusion these vessels. Ligation reduced, increased, harmonics over most spectra. These results imply that study contours as observation point is moved downstream, one may have account separately for contributions...

10.1093/cvr/23.6.465 article EN Cardiovascular Research 1989-06-01

Objective To assess in a prospective study the use of new variable, residual prostatic weight ratio (RPWR), for evaluating clinical outcome after transurethral resection prostate (TURP). Patients and methods From April 1996 to June 1997, 40 men (mean age 70.4 years, range 53–85) with symptomatic benign hyperplasia were evaluated using American Urological Association (AUA) symptom score, measurements mean maximum urinary flow rate (Q ave Q max ), by transrectal ultrasonography (TRUS) before...

10.1046/j.1464-410x.2000.00433.x article EN BJU International 2000-01-01

The frequency properties of arterial beds in organs were studied by temporarily ligating the renal, gastric, splenic or superior mesenteric arteries rats. Blood-pressure waves tail recorded before and during ligations, analysed Fourier's transformation. Their spectra have been found to change profiles following specific patterns with ligations different arteries. results significant regard selectivities organic beds. Such can be clearly explained when circulation system is viewed as an...

10.1111/j.1748-1716.1992.tb09381.x article EN Acta Physiologica Scandinavica 1992-08-01

SummarySummaryTraditionally, transitional cell carcinoma of the upper urinary tract needs a flank incision to remove kidney and lower abdominal ureter bladder cuff. We report surgical techniques initial clinical experience retroperitoneoscopy-assisted nephroureterectomy for treatment this disease. Seven patients (6 males 1 female; mean age 64.3 years, range 47-75 years) with pre-operative diagnosis tumour underwent nephroureterectomy. The operation was performed first by...

10.3109/13645709609153302 article EN Minimally Invasive Therapy & Allied Technologies 1996-01-01

Abstract An alternatively spliced variant of a testis-specific nuclear orphan receptor TR2-11 was identified and designated as TR2-11-t. As result retaining intron 5 this gene, TR2-11-t mRNA encoded truncated with the complete ligand-binding domain deleted. Protein expression both isoforms confirmed using prokaryotic system. In mouse, two TR2 elevated in testis distinct profiles beginning at puberty. increased postnatal day 18, peaked between 20 24 remained high levels throughout adulthood,...

10.1677/joe.0.1520245 article EN Journal of Endocrinology 1997-02-01

AbstractThis study was conducted to determine whether the spermatogenesis of testes and serum sex hormone synthesis are influenced by ligation spermatic arteries. Sixteen adult male dogs were randomly divided into four groups. From our preliminary data spermatogenic arrest decrease testicular volume noted prominently in after The testosterone level decreased luteinizing increased significantly same groups, while no significant changes found with preserved There differences epididymis...

10.3109/01485019308988399 article EN Archives of Andrology 1993-01-01

To investigate whether tumour recurrence or histological changes occur in the Kock pouch, periodic endoscopy with biopsy of pouch was performed 15 patients 6 to 66 months after radical cystectomy and urinary diversion for invasive bladder cancer. Endoscopy undertaken 1 4 times each patient (a total 37 all patients). During endoscopy, random biopsies were taken from wall, afferent efferent nipples. The graded as: (1) villous atrophy (grade 0 3, 0: nearly normal; 1: shortening, villi/crypt...

10.1111/j.1464-410x.1993.tb16172.x article EN British Journal of Urology 1993-10-01

To evaluate whether the ipsilateral renal function on tumor side is a prognostic factor in transitional cell carcinoma (TCC) of ureter.We retrospectively reviewed 129 consecutive patients with ureteral TCC between September 1973 and July 1993 at our hospital. There were 98 males 31 females aged from to 84 years (mean 64.9). Of them, 126 who received intravenous pyelography (IVP) divided into 3 groups according their radiological findings (group 1: nonvisualization kidney side; group 2:...

10.1159/000283054 article EN Urologia Internationalis 1997-01-01

To evaluate the clinical significance of serum alkaline phosphatase (ALP). ALP bone isoenzyme (ALPb) and prostate specific antigen (PSA) levels in predicting bony metastasis prostatic carcinoma.The ALP, ALPb PSA were assessed 32 patients with carcinoma (group 1), 31 without 2), benign hyperplasia 3). Bony metastases detected using whole-body scintigraphy was estimated electrophoretically before surgical or medical treatment. The three markers compared for their ability to predict...

10.1046/j.1464-410x.1997.30613.x article EN British Journal of Urology 1997-02-01

To observe morphological changes in the urothelium after exposure to laser beam and electrohydraulic spark.The pulse dye lithotripter (MDL-2, Candela Corporation, Boston, USA) (AEH-2, Circon ACMI Corporation Stamford, were used directly on bladder mucosa six pigs. Immediately treatment, was prepared for light microscopic scanning electron examination.Both spark caused mucosal denudation, submucosal swelling haemorrhage. There a positive correlation between degree of urothelial damage power...

10.1111/j.1464-410x.1994.tb07106.x article EN British Journal of Urology 1994-12-01

With a high failure rate and multiple postoperative complications, the resection for tumors in elbow reconstruction present formidable challenge to orthopedic surgeons. The maturation of 3-dimension (3D) printing technology has facilitated preoperative design, intraoperative navigation, bone defects patients with complex malignant joint. In order improve prognosis, we explored method tumor aided by 3D this research.The patient underwent nephrectomy clear cell carcinoma left kidney 3 years...

10.1097/md.0000000000034854 article EN cc-by-nc Medicine 2023-09-01

Based on the difference in electrical conductivity between hyperplastic prostatic tissue and of surgical capsule, we have developed a monitoring computer that distinguishes former from latter. The sounds an alarm when cutting loop resectoscope touches followed by automatic cut-off power source 0.4 s later; thus inadvertent perforation capsule can be avoided most cases. function has been tested 73 patients with benign hyperplasia. results show that, Nesbit's technique transurethral resection,...

10.1111/j.1464-410x.1988.tb04266.x article EN British Journal of Urology 1988-07-01

To evaluate and compare changes in pulmonary function after retroperitoneoscopic open surgery.From June 1994 to October 1995. 11 patients (five men six women, mean age 44.7 years, range 29-69) underwent procedures (Group 1) (eight three 57.5 22-73) flank-incision 2). The surgery comprised eight adrenalectomies one each of nephroureterectomy, nephrectomy pyelolithotomy Group 1, five adrenalectomies, four nephroureterectomies, ureterolithotomy excision a retroperitoneal tumour 2. Pulmonary...

10.1046/j.1464-410x.1996.02572.x article EN British Journal of Urology 1996-12-01

Summary The influence of oestrogen on spermatogenesis was evaluated by comparing its effect the testes primary male transsexuals and those who had undergone hormone therapy for prostatic carcinoma. Eight were studied. They been diagnosed clinical psychiatric evidence several years since puberty. Histological sections testicular tissue obtained at reassignment surgery from 8 phenotypic (aged 24–32 years) with an XY chromosome complement studied light microscopy. formalin‐embedded specimens...

10.1111/j.1464-410x.1993.tb16184.x article EN British Journal of Urology 1993-10-01
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