A5058909717- Animal Disease Management and Epidemiology
- Influenza Virus Research Studies
- Biosensors and Analytical Detection
- Spaceflight effects on biology
- Healthcare and Venom Research
- Medical Research and Treatments
- Cardiac Imaging and Diagnostics
- Chemotherapy-induced cardiotoxicity and mitigation
- Coronary Interventions and Diagnostics
- Respiratory viral infections research
- Occupational Health and Performance
- Heart Failure Treatment and Management
- Ergonomics and Musculoskeletal Disorders
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Complementary and Alternative Medicine Studies
- High Altitude and Hypoxia
- Cancer-related molecular mechanisms research
- SARS-CoV-2 detection and testing
- Economic and Financial Impacts of Cancer
- Advanced biosensing and bioanalysis techniques
- Pharmacological Effects of Natural Compounds
- Herbal Medicine Research Studies
- Fungal Biology and Applications
- Cancer, Hypoxia, and Metabolism
Harbin Medical University
2020-2025
Second Affiliated Hospital of Harbin Medical University
2020-2025
Shenzhen Academy of Inspection and Quarantine
2019-2023
Ministry of Education of the People's Republic of China
2022-2023
Animal and Plant Inspection and Quarantine Technology Center of Shenzhen Customs District
2020
Second Affiliated Hospital of Jilin University
2018
Shenzhen Entry-Exit Inspection and Quarantine Bureau
2003-2017
Air Force Institute of Aviation Medicine Affiliated Hospital
2009-2015
Chinese People's Liberation Army
2012-2015
Shanghai Changzheng Hospital
2008-2015
Despite the current antiatherosclerotic and antithrombotic therapies, incidence of advanced atherosclerosis-associated clinical events remains high. Whether long noncoding RNAs (lncRNAs) affect progression atherosclerosis whether they are potential targets for treatment poorly understood. Approach Results: The atherosclerotic lesions was accompanied by dynamic alterations in lncRNA expression, as revealed RNA sequencing quantitative polymerase chain reaction. Among dynamically changing...
There is a lack of evidence regarding the association between plasma phenylacetylglutamine levels and lesion severity clinical prognosis in patients with ST-segment elevation myocardial infarction (STEMI) multivessel coronary disease (MVCD). This study aims to investigate potential as biomarker for major adverse cardiovascular events (MACEs) STEMI MVCD. Clinical data blood samples were collected from 631 MVCD, who underwent primary percutaneous intervention. Quantitative angiography analysis...
Drug resistance is a major factor for the limited efficacy of chemotherapy in gastric cancer treatment. Hypoxia-inducible factor-1α (HIF-1α), central transcriptional hypoxia, suggested to participate resistance. Here, we identified hypoxia-mimic (cobalt chloride) sensitive cell line BGC-823 explore whether diosgenin, an aglycone steroidal saponins, can inhibit invasion and survival solid tumor hypoxic mimic microenvironment. We have shown that diosgenin potent candidate decreasing ability...
A fast, easy-to-implement, highly sensitive, and point-of-care (POC) detection system for frog virus 3 (FV3) is proposed. Combining recombinase polymerase amplification (RPA) CRISPR/Cas12a, a limit of (LoD) 100 aM (60.2 copies/μL) achieved by optimizing RPA primers CRISPR RNAs (crRNAs). For POC detection, smartphone microscopy implemented, an LoD 10 in 40 min. The proposed detects four positive animal-derived samples with quantitation cycle (Cq) value quantitative PCR (qPCR) the range 13 to...
Group II introns are self-splicing RNAs that have mechanistic similarity to the spliceosome complex involved in messenger RNA splicing eukaryotes. These autocatalytic molecules can be reconfigured into highly specific, multiple-turnover ribozymes cleave oligonucleotides trans. We set out use a simplified system of this kind study mechanism cleavage.Unlike other catalytic molecules, group DNA linkages almost as readily linkages. One ribozyme variant cleaves with an efficiency comparable...
Highly photoluminescent (PL) CuInZnxS1+x nanocrystals (NCs) and CuInZnxS1+x/ZnS core/shell NCs were successfully synthesized by a facile colloidal method. First, reliable non-injection method for the synthesis of CuInZnxS2+x was developed with inexpensive reagents. The relative PL quantum yields (QYs) could reach up to 30%, tunable emissions in range 580–780 nm. Then, CuInZnxS2+x/ZnS showed greatly improved optical properties, QY can 60%. Even near-infrared region, still achieve 45% due...
Emerging evidence suggests that cancer stem cells are involved in tumor angiogenesis. The Notch signaling pathway is one of the most important regulators these processes. β -Elemene, a naturally occurring compound extracted from Curcumae Radix , has been used as an antitumor drug for various cancers China. However, its underlying mechanism treatment gastric remains largely unknown. Here, we report CD44+ stem-like (GCSCs) showed enhanced proliferation capacity compared to their CD44−...
Introduction. Posttraumatic stress disorder (PTSD) is accompanied by poor general psychological status (GPS). In the present study, we investigated effects of a Chinese herbal formula on GPS in earthquake survivors with PTSD. Methods. A randomized, double-blind, placebo-controlled trial compared formula, Xiao-Tan-Jie-Yu-Fang (XTJYF), to placebo 2008 Sichuan Patients were randomized into XTJYF (n = 123) and 122) groups. Baseline-to-end-point score changes three global indices Symptom...
High fluorescence intensity nanoparticles were prepared by copolymerization of Eu(TTA)<sub>3</sub>Phen doped styrene and methyl methacrylate.
Ganoderma lucidum spore (GLS), an over-the-counter herbal supplement, is widely used by cancer patients in China. Although preclinical studies have shown it to be safe, complete safety data on GLS still lacking. In this article, we report 5 cases of gastrointestinal that were treated with plus multiple strategies between 2010 and 2011. These presented increased levels the serum tumor marker CA72-4, one most valuable markers for monitoring therapeutic response receiving treatment, after oral...
Since 2014, H5 highly pathogenic avian influenza viruses (HPAIVs) from clade 2.3.4.4 have been persistently circulating in Southern China. This has caused huge losses the poultry industry. In this study, we analysed genetic characteristics of seven H5N6 HPAIVs that infected birds China 2016. Phylogenetic analysis grouped HA, PB2, PA, M and NS genes as MIX-like, NA into Eurasian lineage. The PB1 GS24, GS25, CK46 GS74 strains belonged to VN 2014-like group others were MIX-like. NP GS24 GS25...
Coronary artery calcification (CAC) is a marker of atherosclerosis and thought to be associated with worse clinical outcomes. However, evidence from large-scale high-resolution imaging data lacking. We proposed novel deep learning method that can automatically identify quantify CAC in massive intravascular OCT trained using efficiently generated sparse labels. 1,106,291 images 1,048 patients were collected utilized train evaluate the method. The Dice similarity coefficient for segmentation...
Clade 2.3.4.4 H5 avian influenza viruses (AIVs) are widely prevalent and of significant concern to the poultry industry public health in China. Nowadays, clade H5N6 virus has become a dominant AIV subtype among domestic ducks southern We found that waterfowl-origin (A/goose/Guangdong/16568/2016, GS16568 A/duck/Guangdong/16873/2016, DK16873) isolated from China 2016 could replicate multiple organs inoculated ducks. DK16873 caused mild infections killed 2/5 ducks, did not kill In addition, two...
Acute myocardial infarction (AMI) and cancer are diseases with high morbidity mortality worldwide, bringing a serious economic burden, they share some risk factors. The purpose of this study was to determine the effect on all-cause in-hospital patients AMI.This multicenter retrospective analyzed AMI from Medical Information Mart for Intensive Care IV (MIMIC-IV) database eICU Collaborative Research Database (eICU-CRD) in United States. Patients were divided into two groups based whether had...
Coronary artery calcification (CAC), a surrogate of atherosclerosis, is related to stent underexpansion and adverse cardiac events. However, the effect CAC on plaque stability still controversial morphological significance has yet be elucidated.A retrospective series 419 patients with acute coronary syndrome (ACS) who underwent optical coherence tomography (OCT) were enrolled. Patients classified into three groups based size in culprit plaques features non-culprit among these compared....
To establish nude mouse human gastric cancer orthotopic transplantation models using OB glue paste technique.Using technique, orthopic were established by implanting SGC-7901 and MKN-45 cell strains into the wall of mice. Biological features, growth implanted tumors, success rate auto-metastasis two observed.The rates 94.20% 96%. The hepatic metastasis, pulmonary peritoneal lymphocytic metastasis splenic 42.13% 94.20%, 48.43% 57.97%, 30.83% 36.96%, 67.30% 84.06%, 59.75% 10.53%, respectively....