A5101820005- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- SARS-CoV-2 and COVID-19 Research
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- SARS-CoV-2 detection and testing
- Optical measurement and interference techniques
- Biosensors and Analytical Detection
- Photoacoustic and Ultrasonic Imaging
- Ferroelectric and Piezoelectric Materials
- Advanced Vision and Imaging
- DNA and Nucleic Acid Chemistry
- Remote Sensing and LiDAR Applications
- Corrosion Behavior and Inhibition
- Image Processing Techniques and Applications
- Digital Mental Health Interventions
- Advanced Nanomaterials in Catalysis
- Microwave Dielectric Ceramics Synthesis
- Acoustic Wave Resonator Technologies
- Erythrocyte Function and Pathophysiology
- Advanced Steganography and Watermarking Techniques
- Microfluidic and Bio-sensing Technologies
- Nanocluster Synthesis and Applications
- Inorganic Fluorides and Related Compounds
- Luminescence and Fluorescent Materials
Hangzhou Dianzi University
2025
Southern Medical University
2025
Tsinghua–Berkeley Shenzhen Institute
2020-2024
Tsinghua University
2022-2024
Xiangya Hospital Central South University
2020-2024
Central South University
2015-2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Institute of Soil and Water Conservation
2024
Northwest A&F University
2024
Amplifying free radical production by chemical dynamic catalysis to cause oxidative damage cancer cells has received extensive interest for cancer-specific therapy. The major challenge is inevitable negative modulation on the tumor microenvironment (TME) these species, hindering durable effectiveness. Here we show first time an oxygen vacancy-rich Bi-based regulator that allows environment-adaptive catalysis. Specifically, catalyzes of highly toxic O2.- and . OH in via logic enzymatic...
Clustered regularly interspaced short palindromic repeats, CRISPR, has recently emerged as a powerful molecular biosensing tool for nucleic acids and other biomarkers due to its unique properties such collateral cleavage nature, room temperature reaction conditions, high target-recognition specificity. Numerous platforms have been developed leverage the CRISPR assay ultrasensitive applications. However, be considered new gold standard, several key challenges must addressed. In this paper, we...
The trade-off between electrostrain and strain hysteresis for piezo/ferroelectric materials largely restrains the development of high precision actuators remains unresolved over past few decades. Here, a simple composition (Bi0.5Na0.5)1-x/100Srx/100TiO3 in ergodic relaxor state is collaboratively designed through segregated domain structure with ferroelectric core, local polarization heterogeneity, defect engineering. core can act as seed to facilitate field-induced nonpolar-to-polar...
A transition-metal-free decarboxylative fluorination of electron-rich five-membered heteroaromatics, including furan-, pyrazole-, isoxazole-, thiophene-, indole-, benzofuran- and indazolecarboxylic acids, with Selectfluor is reported. Fluorinated dimer products were observed for nitrogen-containing heteroaromatic carboxylic such as indole pyrazole. An effective method has been developed to synthesize the monomer 2- 3-fluoroindoles Li2CO3 base at low temperature.
Levels of type 2 cytokines are elevated in the blood and intestinal tissues ulcerative colitis (UC) patients active phase; this phenomenon indicates participation immune response UC progression. The beneficial effects melatonin dextran sodium sulfate (DSS) 2,4,6-trinitrobenzene sulfonic acid (TNBS) models have been illustrated, but its role oxazolone (Oxa)-induced model (driven by response) remains relatively unknown. We investigated relationship between concentration severity UC, revealing...
Manipulation of cell-cell interactions via cell surface engineering has potential biomedical applications in tissue and therapy. However, manipulation the comprehensive multiple intercellular remains a challenge missing elements. Herein, utilizing DNA triangular prism (TP) branched polymer (BP) as functional modules, we fabricate tunable scaffold networks on surface. The responsiveness recognition, aggregation dissociation could be modulated by aptamer-functionalized with high accuracy...
Abstract Microchannels are the essential elements in animals, plants, and various artificial devices such as soft robotics, wearable sensors, organs-on-a-chip. However, three-dimensional (3D) microchannels with complex geometry a high aspect ratio remain challenging to generate by conventional methods lithography, template dissolution, matrix swollen processes, although they widespread nature. Here, we propose simple solvent-free fabrication method capable of producing monolithic 3D...
Fluorescence visualization (FV) in the near-infrared (NIR) window promises to break through signal-to-background ratio (SBR) bottleneck of traditional visible-light-driven FV methods. However, straightforward NIR-FV has not been realized, owing lack methods readily transduce NIR responses into instrument-free, naked eye-recognizable outputs. Now, an initiation-input-transduction platform comprising a well-designed fluorophore as signal initiator and lanthanide-doped nanocrystals transducer...
Abstract The COVID-19 is currently spreading around the world, which has posed significant threats to global health and economy. Convalescent plasma confirmed effective against novel corona virus in preliminary studies. In this paper, we first described therapeutic schedule, antibody detection method, indications, contraindications of convalescent plasmas, reported operability treatment by case study.
<title>Abstract</title> The early detection of mental disorders in adolescents represents a significant global public health challenge. Due to the complex and subtle nature disorders, making it difficult detect abnormalities using single factor. Additionally, generalized multimodal <bold>C</bold>omputer-<bold>A</bold>ided <bold>S</bold>creening (<bold>CAS)</bold> systems, incorporating interactive robots for adolescent assessment, remain unavailable. In this study, we present an Android...
A fast, easy-to-implement, highly sensitive, and point-of-care (POC) detection system for frog virus 3 (FV3) is proposed. Combining recombinase polymerase amplification (RPA) CRISPR/Cas12a, a limit of (LoD) 100 aM (60.2 copies/μL) achieved by optimizing RPA primers CRISPR RNAs (crRNAs). For POC detection, smartphone microscopy implemented, an LoD 10 in 40 min. The proposed detects four positive animal-derived samples with quantitation cycle (Cq) value quantitative PCR (qPCR) the range 13 to...
Selenocysteine (Sec) has proven to be the dominant active site of diverse selenoproteins that are directly linked with human health and disease. Thus, understanding critical functions dynamics endogenous Sec at cellular tissue levels is highly demanded. However, no method been reported capable providing reliable quantitative imaging analysis in living systems, especially deep tissues, low background signal high sensitivity resolution simultaneously. To address this challenge, we herein...
Convolutional autoencoders are making a significant impact on computer vision and signal processing communities. In this work, convolutional autoencoder denoising method is proposed to restore the corrupted laser stripe images of depth sensor, which directly reduces external noise sensor so as increase its accuracy. To reduce amount training data avoid overfitting, patch size image determined, basis small-scale dataset called Laser Stripe Image Patch (LSIP) created. Also, 14-layers...
Autoimmune hemolytic anemia (AIHA) results from the excessive destruction of red blood cells (RBCs). Nowadays, there is no exact treatment for severe AIHA and our current medical therapies do not effectively stop progression AIHA. Therapeutic plasma exchange (TPE) used as emergency therapy that sometimes helpful. Whole (WBE) based on TPE while its replacement liquids are donor RBCs fresh plasma. We hypothesized WBE transfusion might be able to control process acute hemolysis, avoid crisis,...
DNA-based molecular communications (DMC) are critical for regulating biological networks to maintain stable organismic functions. However, the complicated, time-consuming information transmission process involved in genome-coded DMC and limited, vulnerable decoding activity generally lead communication impairment or failure, response external stimuli. Herein, we present a conceptually innovative strategy mediated by DNA framework-based artificial encoder. With free-radical cascade as...
Delineation of small malignant lesions and their vasculature enables early accurate diagnosis hepatocellular carcinoma (HCC). However, it remains challenging to identify these features simultaneously by noninvasive imaging technology. Reverse contrast emerges as a powerful means detect early-stage HCC taking inspiration from the intrinsic liver phagocytosis toward exogenous agents generate negative tumor-to-normal tissue signals. this mechanism conflicts with signal-enhancing requirements...