A5007746021- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Advanced biosensing and bioanalysis techniques
- Advanced Sensor and Energy Harvesting Materials
- Antibiotic Resistance in Bacteria
- CRISPR and Genetic Engineering
- Conducting polymers and applications
- Blood disorders and treatments
- Antifungal resistance and susceptibility
- Cardiac Arrest and Resuscitation
- Bacterial Identification and Susceptibility Testing
- Pancreatitis Pathology and Treatment
- Sepsis Diagnosis and Treatment
- Advanced Materials and Mechanics
- Pneumonia and Respiratory Infections
- Clostridium difficile and Clostridium perfringens research
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Viral Infections and Immunology Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac, Anesthesia and Surgical Outcomes
- Metabolomics and Mass Spectrometry Studies
- Infectious Encephalopathies and Encephalitis
- Appendicitis Diagnosis and Management
- Acute Kidney Injury Research
First Affiliated Hospital of Xi'an Jiaotong University
2022-2025
Peking University
2020-2024
Peking University Third Hospital
2020-2024
Tsinghua–Berkeley Shenzhen Institute
2021-2024
Tsinghua University
2024
Shenzhen Bay Laboratory
2024
South China University of Technology
2019
Polymyxin B sulfate (PBS) and colistin (CS) are the last-line treatments for infections caused by multidrug-resistant Gram-negative bacteria, but their efficacy safety have not been validated. The aims of current study were to (1) determine among critically ill patients influencing factors, (2) relationships drug exposure with safety, provide evidence precision dosing. This retrospective included 100 treated PBS 80 CS. outcomes clinical 30-day mortality, while indicator was acute kidney...
ABSTRACT Predicting vancomycin exposure is essential for optimizing dosing regimens in sepsis patients. While population pharmacokinetic (PPK) models are commonly used, their performance limited. Machine learning (ML) offer advantages over PPK models, but it remains unclear which model—PPK, Bayesian, ML, or hybrid PPK-ML—is best predicting across different clinical scenarios This study compares the of these 24 hour area under blood concentration curve (AUC ) to support precision care. Data...
Flexible polyurethane foams (FPUFs) have wide applications in numerous fields; however, their high flammability seriously threatens the environment and humans. Thus, it is of practical significance to realize self-extinguishing property FPUF. Herein, silica aerogel sodium alginate (SA) were deposited on skeleton surface FPUF utilizing electrostatic force through layer-by-layer assembly. The thermal, flame-retardant, smoke-suppression properties coated improved effectively. With increase...
Purpose: Voriconazole (VRC) is an antifungal agent which used for treatment and prophylaxis of invasive fungal infections. The common clinical adverse reactions mainly include central nervous system (CNS) toxicity abnormal liver function. These limit the use voriconazole to a certain extent. Therefore, aim this study was analyze risk factors neurotoxic side effects determine plasma trough concentration ( C min ) threshold voriconazole-induced CNS toxicity, so as improve safety treatment....
Background: Voriconazole is a potent antifungal drug with complex pharmacokinetics caused by time-dependent inhibition and polymorphisms of metabolizing enzymes. It also exhibits different pharmacokinetic characteristics between adults children. An understanding these alterations in essential for pediatric dose optimization. Objective: To determine voriconazole plasma exposure the population further investigate optimal dosage regimens. Methods: adult physiologically based (PBPK) model...
The dosage regimen of vancomycin, teicoplanin and daptomycin remains controversial for critically ill patients undergoing continuous renal replacement therapy (CRRT). Monte Carlo simulation was applied to identify the optimal regimens antimicrobial agents in with methicillin-resistant Staphylococcus aureus (MRSA) infections based on mechanisms different CRRT modalities drug clearance. vancomycin received a doses ≤ 30 mL/kg/h 20 mg/kg loading dose followed by 500 mg every 8 h, while 1 g 12 h...
Patients with augmented renal clearance (ARC) have been described as having low vancomycin concentration. However, the pharmacokinetic model that best describes in patients ARC has not clarified. The purpose of this study is to determine Chinese adults and recommend dosage for different function, including ARC. We retrospectively collected 424 serum concentrations from 209 performed a population using NONMEM 7.4.4. final indicated rate increased together creatinine clearance, exhibited...
The optimal dose of vancomycin in critically ill patients receiving continuous venovenous hemofiltration (CVVH) remains unclear. objective this study was to identify factors that significantly affect pharmacokinetic profiles and further investigate the dosage regimens for undergoing CVVH based on population pharmacokinetics pharmacodynamic analysis. A prospective analysis performed at surgical intensive care unit a level tertiary hospital. We included 11 intravenous vancomycin. Serial blood...
Abstract Study Objective Few studies have been conducted to quantify the exposure target of vancomycin in intensive care unit (ICU) patients undergoing continuous renal replacement therapy (CRRT) and provide optimized dosage regimens. We aimed determine dosing recommendations using data from an open database critically ill CRRT. Design A retrospective observational cohort study. Data Source large public database. Patients The adult who received intravenous CRRT treatment between 2017 2019...
Abstract Frog virus 3 (FV3, genera Ranavirus , family Iridoviridae ), a double-stranded DNA virus, results in irreparable damage to biodiversity and significant economic losses aquaculture. Although the existing FV3 detection methods are of high sensitivity specificity, complex procedure requirement expensive instruments limit their practical implantation. Herein, we develop fast, easy-to-implement, highly sensitive, point-of-care (POC) system for FV3. Combining recombinase polymerase...
Abstract RNA detection is crucial for biological research and clinical diagnosis. The current methods include both direct amplification-based detection. These require complicated procedures, suffering from low sensitivity, slow turnaround, amplification bias. CRISPR/Cas13a system a method via target induced collateral cleavage activity. However, to detect concentration with CRISPR/Cas13a, always required. Herein, we optimize the components of assay enhance sensitivity viral which improve...
Thrombocytopenia can cause substantial morbidity and mortality in critically ill patients. There are multiple etiology factors various mechanisms associated with thrombocytopenia, of which drug-induced thrombocytopenia (DITP) deserves attention. Herein, we describe a case severe during intensive care unit (ICU) hospitalization that was likely to be vancomycin. By revealing the process identifying this DITP reviewing relevant clinical studies, risk alert vancomycin-related hematotoxicity...
Thrombocytopenia can cause substantial morbidity and mortality in critically ill patients. There are multiple etiology factors various mechanisms associated with thrombocytopenia, of which drug-induced thrombocytopenia (DITP) deserves attention. Herein, we describe a case severe during intensive care unit (ICU) hospitalization that was probable to be vancomycin. In addition, clinical studies evaluating caused by vancomycin were systematically reviewed 6 acceptable quality included analyzed....
Limited evidence exists regarding the clinical baseline characteristics at admission for acute kidney injury (AKI) before and after interventional cardiac procedures (ICP) in elderly patients with coronary artery disease (CAD).
Sepsis is a life-threatening organ dysfunction caused by an excessive host response to infection, manifested elevated levels of inflammatory cytokines. At present, the use hemoperfusion remove cytokines from bloodstream has been expanding. Meanwhile, pharmacokinetics and pharmacodynamics characteristics antibiotics in critically ill patients may be impacted hemoperfusion. The patient was 69-year-old male with poorly controlled type 2 diabetes. When admitted ICU, Multiple Organ Dysfunction...