A5002893532- Folate and B Vitamins Research
- Acute Myocardial Infarction Research
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Autophagy in Disease and Therapy
- Cell Adhesion Molecules Research
- Coronary Interventions and Diagnostics
- Iron Metabolism and Disorders
- Nutrition and Health in Aging
- Medication Adherence and Compliance
- Adipose Tissue and Metabolism
- Metabolism and Genetic Disorders
- Trace Elements in Health
- Cardiac Fibrosis and Remodeling
- Metabolomics and Mass Spectrometry Studies
- Nutritional Studies and Diet
- Ultrasound and Hyperthermia Applications
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sirtuins and Resveratrol in Medicine
- Obesity, Physical Activity, Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gout, Hyperuricemia, Uric Acid
- Heart Failure Treatment and Management
Harbin Medical University
2020-2025
Second Affiliated Hospital of Harbin Medical University
2020-2025
Ministry of Education of the People's Republic of China
2020-2024
Nationwide Children's Hospital
2023
Heilongjiang University of Chinese Medicine
2020-2023
Air Force Medical University
2017-2021
Xijing Hospital
2017-2021
Zhangqiu City People's Hospital
2021
Fourth People’s Hospital of Jinan
2019
Nanxi Mountain Hospital
2013
Abstract This study investigated the effects of melatonin on diabetic cardiomyopathy ( DCM ) and determined underlying mechanisms. Echocardiography indicated that notably mitigated adverse left ventricle remodeling alleviated cardiac dysfunction in . The mechanisms were attributed to increased autophagy, reduced apoptosis, mitochondrial dysfunction. Furthermore, inhibited Mst1 phosphorylation promoted Sirt3 expression These results may exert its through Mst1/Sirt3 signaling. To verify this...
Mitophagy eliminates dysfunctional mitochondria and thus plays a cardinal role in diabetic cardiomyopathy (DCM). We observed the favourable effects of melatonin on cardiomyocyte mitophagy mice with DCM elucidated their underlying mechanisms. Electron microscopy flow cytometric analysis revealed that reduced number impaired heart. Other than decreasing mitochondrial biogenesis, increased clearance DCM. Melatonin LC3 II expression as well colocalization lysosomes HG-treated cardiomyocytes...
Abstract Ferroptosis is a regulatory cell death process pivotal in myocardial ischemia–reperfusion (I/R) injury. However, the precise mechanism underlying ferroptosis remains less known. In this study, we investigated pathophysiological mechanisms of methylmalonic acid (MMA) associated with activation cardiomyocytes after I/R. We found an increase level MMA patients acute injury reperfusion and AC16 cells under hypoxia/reoxygenation (H/R) condition. treatment was to be excessive oxidative...
Inherited methylmalonic acidemia is characterized by mitochondrial dysfunction, oxidative stress, and damage of mitochondria-rich organs in children. It unclear whether acid (MMA) related to poor prognosis adults. The study aims investigate the associations MMA with all-cause cause-specific mortality general population. Overall, 23,437 adults from US National Health Nutrition Examination Survey (NHANES) were enrolled. NHANES 1999-2004 2011-2014 separately used as primary validation subsets...
Rationale: Atherosclerosis plaque rupture (PR) is the pathological basis and chief culprit of most acute cardiovascular events death. Given complex important role macrophage apoptosis autophagy in affecting stability, an unanswered question include whether, how, immunity-related GTPase family M protein (IRGM) its mouse orthologue IRGM1 affect survival atherosclerotic stability. Methods: To investigate whether serum IRGM ST-segment elevation myocardial infarction (STEMI) patients related to...
Inflammation and lipid accumulation are key events in atherosclerosis progression. Despite arsenic trioxide's (ATO) toxicity, at appropriate doses, it is a useful treatment for various diseases treatment. ATO prevents vascular restenosis; however, its effects on atherosclerotic plaque development instability remain unclear. ApoE-/- mice were fed high-fat diet 4 months, starting the third month, was intravenously administered every other day. Atherosclerotic lesion size, histological...
Abstract A high serum anion gap (AG) at the time of patient admission can lead to deterioration or even death; data are lacking for patients who suffer acute heart failure (AHF). The present study aimed exploring impact AG (SAG) levels on in-hospital mortality in AHF patients. conducted retrospective analysis from medical information mart intensive care (MIMIC-IV) database severe cases. Serum AG, age, sex, concomitant diseases and laboratory tests were collected admission. Multivariate Cox...
OBJECTIVE Despite that periodical monitoring of cobalamin (vitamin B12) in metformin-treated patients with diabetes is recommended, cobalamin-associated mortality benefits or risks remain unclear. We investigated the association between intake and related biomarkers risk adults using metformin not. RESEARCH DESIGN AND METHODS This study included 3,277 type 2 from National Health Nutrition Examination Survey (NHANES) followed up until 31 December 2015. Weighted Cox proportional hazards...
Abstract Background Cost-related medication nonadherence (CRN) is associated with poor prognosis among patients chronic obstructive pulmonary disease (COPD), a population that requires long-term treatment for secondary prevention. In this study, we aimed to estimate the prevalence and sociodemographic characteristics of CRN in individuals COPD US. Methods nationally representative survey US adults National Health Interview Survey (2013–2020), identified aged ≥18 years self-reported history...
Homocysteine (Hcy) is a recognized cardiovascular disease (CVD) risk factor linked with atherosclerosis. However, the association between Hcy and myocardial injury little known.
Sarcopenia is an emerging risk factor for cardiovascular disease (CVD). However, previous studies did not take into consideration the impact of changes in sarcopenia status. We investigated relationship between status and incident CVD. Participants from two prospective cohorts: China Health Retirement Longitudinal Study (CHARLS) (HRS) were included. Changes assessed by at initial surveys. CVD was ascertained self-reported physician-diagnosed heart or stroke. A total 6,608 4,316 adults CHARLS...
Background: High sensitivity CRP (hs-CRP) has attracted intense interest in risk assessment. We aimed to explore its prognostic value patients with acute myocardial infarction (AMI). Methods and Results: enrolled 4,504 consecutive AMI this prospective cohort study. The associations between hs-CRP levels the incidence of in-hospital HF was evaluated by logistic regression analysis. association cumulative after hospitalization were Fine-Gray proportional sub-distribution hazards models,...
Large-dose melatonin treatment in animal experiments was hardly translated into humans, which may explain the dilemma that protective effects against myocardial injury have been challenged by clinical trials. Ultrasound-targeted microbubble destruction (UTMD) has considered a promising drug and gene delivery system to target tissue. We aim investigate whether cardiac of receptor mediated UTMD technology optimizes efficacy clinically equivalent dose sepsis-induced cardiomyopathy.Melatonin...
Objective D-dimer might serve as a marker of thrombogenesis and hypercoagulable state following plaque rupture. Few studies explore the association between baseline levels incidence heart failure (HF), all-cause mortality in an acute myocardial infarction (AMI) population. We aimed to this association. Methods enrolled 4504 consecutive patients with AMI complete data prospective cohort study explored plasma on admission HF, mortality. Results Over median follow-up 1 year, 1112 (24.7%)...
The disruption of mitochondrial dynamics is responsible for the development diabetic cardiomyopathy (DCM). However, mechanisms that regulate balance fission and fusion are not well-understood. Wild-type, Mst1 transgenic knockout mice were induced with experimental diabetes by streptozotocin injection. In addition, primary neonatal cardiomyocytes isolated cultured to simulate explore mechanisms. Echocardiograms hemodynamic measurements revealed alleviated left ventricular remodeling cardiac...
The inconsistent relationship between Vitamin B12 (B12), methylmalonic acid (MMA, marker of deficiency) and mortality was poorly understood, especially in patients with coronary heart disease (CHD). This study aims to investigate the association serum MMA, B12-related biomarkers (serum level, dietary intake, supplement use, sensibility B12) all-cause cardiovascular adults CHD.The data this were from a subcohort within US National Health Nutrition Examination Survey (NHANES). We included...