A5100447765- Autophagy in Disease and Therapy
- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Dermatology and Skin Diseases
- Extracellular vesicles in disease
- Autoimmune Bullous Skin Diseases
- Hippo pathway signaling and YAP/TAZ
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Plant responses to water stress
- Drug Transport and Resistance Mechanisms
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Ferroptosis and cancer prognosis
- Cardiovascular Function and Risk Factors
- Cancer and Skin Lesions
- Ion Channels and Receptors
Shanghai University of Medicine and Health Sciences
2021-2025
Southern Medical University
2025
Capital Medical University
2025
National Clinical Research Center for Digestive Diseases
2025
Beijing Tian Tan Hospital
2025
Air Force Medical University
2015-2024
Xijing Hospital
2015-2024
Xinjiang Medical University
2024
North China Electric Power University
2024
Second Affiliated Hospital of Xinjiang Medical University
2024
Acute myocardial infarction is a major health problem and the leading cause of death worldwide. Myocardial apoptosis induced by injury involved in pathophysiology heart failure. Therapeutic stem cell therapy has potential to be an effective favorable treatment for ischemic disease. Exosomes derived from cells have been shown effectively repair MI injury-induced cardiomyocyte damage. However, cardioprotective benefits adipose tissue-derived mesenchymal (ADSC)-Exos remain unknown. This study...
Abstract This study investigated the effects of melatonin on diabetic cardiomyopathy ( DCM ) and determined underlying mechanisms. Echocardiography indicated that notably mitigated adverse left ventricle remodeling alleviated cardiac dysfunction in . The mechanisms were attributed to increased autophagy, reduced apoptosis, mitochondrial dysfunction. Furthermore, inhibited Mst1 phosphorylation promoted Sirt3 expression These results may exert its through Mst1/Sirt3 signaling. To verify this...
Mitophagy eliminates dysfunctional mitochondria and thus plays a cardinal role in diabetic cardiomyopathy (DCM). We observed the favourable effects of melatonin on cardiomyocyte mitophagy mice with DCM elucidated their underlying mechanisms. Electron microscopy flow cytometric analysis revealed that reduced number impaired heart. Other than decreasing mitochondrial biogenesis, increased clearance DCM. Melatonin LC3 II expression as well colocalization lysosomes HG-treated cardiomyocytes...
Cisplatin is widely used in the treatment of solid tumors, but its application greatly limited due to nephrotoxicity; thus, there still no effective medicine for cisplatin-induced acute kidney injury (Cis-AKI). We previously identified that polydatin (PD) exerts nephroprotective effects by antioxidative stress AKI models. Recent evidence suggests oxidative stress-induced molecular events overlap with process ferroptosis and are common targets, such as glutathione (GSH) depletion lipid...
Abstract Background Ferroptosis, which is characterized by lipid peroxidation and iron accumulation, closely associated with the pathogenesis of acute renal injury (AKI). Cyanidin-3-glucoside (C3G), a typical flavonoid that has anti-inflammatory antioxidant effects on ischemia‒reperfusion (I/R) injury, can induce AMP-activated protein kinase (AMPK) activation. This study aimed to show C3G exerts nephroprotective against I/R-AKI related ferroptosis regulating AMPK pathway. Methods...
Staphylococcus aureus, a known contributor to non-healing wounds, releases vesicles (SAVs) that influence the delicate balance of host-pathogen interactions. Efferocytosis, process by which macrophages clear apoptotic cells, plays key role in successful wound healing. However, precise impact SAVs on repair and efferocytosis remains unknown. Filtration, ultracentrifugation, iodixanol density gradient centrifugation were used purify bacterial vesicles. Transmission electron microscopy (TEM),...
Myocardial infarction (MI), which is characterized by chamber dilation and LV dysfunction, associated with substantially higher mortality. We investigated the effects underlying mechanisms of Luteolin on post-infarction cardiac dysfunction. was constructed left anterior descending coronary artery ligation. In vitro, cultured neonatal cardiomyocytes subjected to simulated MI were used probe mechanism. significantly improved function, decreased enzyme inflammatory cytokines release after MI....
The objective was to investigate the efficacy and safety of clopidogrel-aspirin versus aspirin alone in patients after ischemic stroke by glycemic status using data from Intensive Statin Antiplatelet Therapy for Acute High-risk Intracranial or Extracranial Atherosclerosis (INSPIRES) trial. Patients with mild high-risk transient attack (TIA) were randomized alone. They categorized into 3 subgroups according based on medical history diagnosis a clinician during hospitalization: without type 2...
Abstract The increasing global incidence of atopic dermatitis (AD) in children, especially Western industrialized nations, has attracted considerable attention. hygiene hypothesis, which posits that early pathogen exposure is crucial for immune system development, central to understanding this trend. Furthermore, advanced machine learning algorithms have provided fresh insights into the interactions among various risk factors. This study investigates relationship between childhood antibiotic...
Cardiovascular complications account for a substantial proportion of morbidity and mortality in diabetic patients. Abnormalities cardiac microvascular endothelial cells (CMECs) lead to impaired vessel integrity subsequent dysfunction, underlining the importance coronary dysfunction. In this study, experimental diabetes models were constructed using Mst1 transgenic, knockout sirt1 mice. Diabetic transgenic mice exhibited microvessel decreased function. overexpression deceased CMECs autophagy...
Sirt6 has been reported to play a protective role in macrophage foam cell formation, but whether controls atherosclerosis plaque stability and it can reduce the interaction between endothelial cells macrophages remains unclear. The aim of this study was investigate effect on underlying mechanisms. We used Tie2-Cre transgenic mice as Cre-lox tool delete floxed sequences during adulthood establish −/− mice. ApoE :Sirt6 :Sirt6Tg were our investigation. After 16 week high-fat diet, developed...
Glioblastoma (GBM), as the most common primary brain tumor, usually results in an extremely poor prognosis, which glioma stem cells (GSCs) and their immunosuppressive microenvironment prominently intervene resistance to radiotherapy chemotherapy that directly leads tumor recurrence shortened survival time. The specific mechanism through exosomes generated from GSCs support creation of remains unknown, while it is acknowledged be engaged intercellular communication regulation...
Apoptosis is associated with various myocardial diseases. Angiotensin II (Ang II) plays a central role in the pathogenesis of RAAS-triggered cardiac apoptosis. Our previous studies showed that mammalian Ste20-like kinase 1 (Mst1) aggravates dysfunction cardiomyocyte under pathological conditions, but its Ang II-mediated apoptosis not known. We addressed this present study by investigating whether cardiac-specific Mst1 knockout can alleviate II-induced along underlying mechanisms. In vitro...
Immune suppressive microenvironment in tumor emerges as the main obstacle for cancer immunotherapy. In this study, we identified that HIF1α was activated associated macrophages and acted an important factor immune microenvironment. Epigenetically silencing of Hif1α via histone H3 methylation promoter region achieved by CRISPR/dCas9-EZH2 system, which methylase EZH2 recruited to specifically. The silenced macrophage, namely HERM (Hif1α Repressed Macrophage) manifested inheritable suppressing...
Hypertrophic scar (HS), a fibroproliferative disorder caused by abnormal wound healing after skin injury, which is characterized excessive deposition of extracellular matrix and invasive growth fibroblasts. Recent studies have shown that some non-coding RNA implicated the formation HS, but mechanism remains unclear. In this study, we found lncRNA TRHDE-AS1 was downregulated in HS tissues HSFs, level negatively correlated with miR-181a-5p tissue HSFs. Overexpressed significantly suppressed...
Background: Endothelial-to-mesenchymal transition (EndMT) is an important source of myofibroblasts that directly affects cardiac function in diabetic cardiomyopathy (DCM) via unknown underlying mechanism. Sirt6 a member the Sirtuin family NAD(+)-dependent enzymes plays role glucose and fatty acid metabolism. In this study, we investigated whether participates EndMT during development T2DM possible regulatory mechanisms. Methods: Endothelium-specific knockout (Sirt6-KO EC ) mice (C57BL/6...