A5100403117- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Cutaneous lymphoproliferative disorders research
- Malaria Research and Control
- Cardiac Arrest and Resuscitation
- Lymphoma Diagnosis and Treatment
- Sphingolipid Metabolism and Signaling
- Obesity, Physical Activity, Diet
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Lymphoblastic Leukemia research
- Intraocular Surgery and Lenses
- Thermal Regulation in Medicine
- Viral-associated cancers and disorders
- Ocular Infections and Treatments
- Corneal surgery and disorders
- Autoimmune Bullous Skin Diseases
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Viral Infections and Outbreaks Research
- Nail Diseases and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Acute Myeloid Leukemia Research
- Birth, Development, and Health
- T-cell and Retrovirus Studies
- Barrier Structure and Function Studies
Sichuan University
2014-2024
West China Hospital of Sichuan University
2014-2024
Yangzhou University
2024
Children's Hospital of Capital Institute of Pediatrics
2024
Jining Medical University
2022-2024
Shandong University
2024
Pojen General Hospital
2024
Capital Institute of Pediatrics
2024
Soochow University
2023
Public Health Clinical Center of Chengdu
2021-2022
Dengue has broad clinical presentation with unpredictable evolution and outcome. We aimed to evaluate the utility of C-reactive protein (CRP) levels for distinguishing between mild severe cases in early phase dengue illness. retrospectively evaluated adults from 2006 2014, according 1997 2009 World Health Organization (WHO) criteria severity. Of 191 included patients, 32.9% had nonshock hemorrhagic fever (DHF), 3.1% shock syndrome (DSS), 7.9% dengue. The risk DHF/DSS is significantly related...
Abstract Background Traumatic brain injury (TBI) provokes secondary pathological damage, such as damage to the blood–brain barrier (BBB), ischaemia and inflammation. Major facilitator superfamily domain-containing 2a (Mfsd2a) has been demonstrated be critical in limiting increase BBB vesicle transcytosis following injury. Recent studies suggest that a novel selective modulator of sphingosine-1-phosphate receptor 1 (S1P1), CYM-5442, maintains integrity by restricting during acute ischaemic...
Osteoarthritis (OA) is one of the most prevalent arthritis types globally, with knee being particularly susceptible due to its frequent and strenuous use. Urolithin B (UB) exhibits various biological properties, meniscal repair playing an important role in preventing OA. This study aimed explore impact UB on regeneration OA progression. Initially, we explored effect cells. Utilizing cell counting kit (CCK)-8 assay, determined optimum concentration treatment. Enzyme-linked immunosorbent assay...
Kawasaki disease (KD) is the leading cause of acquired heart during childhood in developed countries. The mechanism and biomarkers KD remain to be determined. In this study, we sought elucidate potential plasma proteomic markers patients comparison that febrile controls. Plasma samples from controls were subjected two-dimensional polyacrylamide gel electrophoresis analysis. Differential protein displays between Fibrinogen beta gamma chains, alpha-1-antitrypsin (A1AT), CD5 antigen-like...
Abstract Timed degradation of the cyclin-dependent kinase inhibitor p27 Kip1 by E3 ubiquitin ligase F-box protein SKP2 is critical for T-cell progression into cell cycle, coordinating proliferation and differentiation processes. expression regulated mitogenic stimuli Notch signaling, a key pathway in development acute lymphoblastic leukemia (T-ALL); however, it not known whether plays role T-ALL. Here, we determined that function relevant T-ALL leukemogenesis, whereas dispensable...
Clinical differentiation of influenza from dengue and other febrile illnesses (OFI) is difficult, available rapid diagnostic tests have limited sensitivity.We conducted a retrospective study to compare clinical laboratory findings between (i) (ii) OFI.Of 849 enrolled patients, the mean time illness onset hospital presentation was 1.7, 3.7, 3 days for influenza, dengue, OFI, respectively. Among pediatric patients (≤18 years) (445 24 130 OFI), we identified absence rashes, no leukopenia,...
Paeoniflorin (PF) extracted from the root of Paeonia lactiflora pall, displays anti-inflammation properties in several animal models. Adhesion molecules are important for recruitment leucocyte to vessel wall and involved pathogenesis various autoimmune inflammatory diseases. Herein, we investigate effects PF on adhesion molecule expression a mouse model cutaneous Arthus reaction cultured human dermal microvascular endothelial cells (HDMECs). We showed that significantly ameliorated immune...
Alertness to dengue and making a timely diagnosis is extremely important in the treatment of containment epidemics. We evaluated complementary role clinical-practice-based laboratory data facilitating suspicion/diagnosis dengue. One hundred overall (57 fever [DF] 43 hemorrhagic [DHF]) cases another 100 nondengue (78 viral infections other than dengue, 6 bacterial sepsis, 16 miscellaneous diseases) were analyzed. separately compared individual variables (platelet count [PC] , prothrombin time...
Appropriate induction of the early Th1 cytokine IL-12 is a critical defense directed against viral infection. We have previously shown that different viruses elicited either or IFNα dependent reactions. Using dengue-2 virus, we sought to explore how induced expression by monocytic and its derived dendritic cells.We employed human cell line, THP-1, investigate whether differentiation cells involved in switch between induction. Flow cytometry, RT-PCR ELISA were respectively used determine...
Copper chaperone for superoxide dismutase-1 (CCS-1), facilitating copper insertion into dismutase 1 (SOD-1), is present in the nucleus. However, it unknown how CCS-1 translocated to The study was undertaken determine effect of on nuclear translocation CCS-1. Human umbilical vein endothelial cells (HUVECs) were subjected hypoxia, causing an increase both and Treatment with tetraethylenepentamine (TEPA) not only decreased total cellular concentration copper, but also completely suppressed...
C-type lectins play a crucial role as pathogen-recognition receptors for the dengue virus, which is responsible causing both fever (DF) and hemorrhagic (DHF). DHF serious illness caused by exists in four different serotypes: DEN-1, DEN-2, DEN-3, DEN-4. We conducted genetic association study, during significant DEN-2 outbreak southern Taiwan, to explore how variations neck-region length of L-SIGN (also known CD209L, CD299, or CLEC4M) impact severity infection. PCR genotyping was utilized...
The aim of this study was to observe the influence differential nutritional status on bone age (BA) change according body mass index (BMI) and analyze risk advanced in children with overweight obesity. In total 23,305 from Beijing were included cross-sectional study. Childhood obesity defined China World Health Organization growth criteria. data analyzed by R coding platform version 4.3.0. Under Chinese criteria, 29%, 15%, 4% boys overweight; 33%, 3% obesity; 39%, 25%, 2% girls 37%, 42% 1%...
Abstract Background We hypothesized that mild hypothermia may improve brain microcirculation by reducing cerebral microvascular endothelial cells apoptosis, and this effect be maximized moving up the initiation of from after return spontaneous circulation (ROSC) to start cardiopulmonary resuscitation (CPR). Methods A total 35 rats were randomized into intra‐arrest group (IAH), post‐resuscitation (PRH), normothermia (NT), or sham control group. craniotomy exposed parietal cortex for...
In 1964, Sweet described an acute febrile neutrophilic dermatosis. It is now widely accepted that syndrome one of the associated dermatoses. Herein, we describe unusual case in a 5-year-old child who suffered from recurrent papules, plaques, and blisters on his face trunk after initial onset fever without obvious cause. Two skin biopsies were performed. The histopathological findings left arm biopsy showed subepidermal blister with dense infiltrating neutrophils within superficial to middle...
Since its introduction in 1995, laparoscopic living donor nephrectomy (LDN) has been shown to alleviate postoperative pain, shorten hospital stay, reduce loss and improve cosmesis while hastening the recovery of normal activities donors.1-3 However, there much controversy over minimally invasive surgery with transperitoneal or retroperitoneal approach for nephrectomy. In this non-randomized retrospective study, we analyzed some parameters donors who had undergone LDN compared those...
Objectives: Epinephrine shortages affect nearly all American emergency medical services (EMS) systems. Utilization of expired epinephrine could mitigate this situation in daily EMS operations. Concerns about using medications include sterility, potency, and potential harmful chemical decay byproducts. There are no cross-platform analyses sterility purity multiple samples parenteral epinephrine. We hypothesized that injections will remain sterile retain their active ingredient's content for...