A5082582239- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Fungal Infections and Studies
- Autoimmune Bullous Skin Diseases
- Prostate Cancer Treatment and Research
- Viral-associated cancers and disorders
- Histiocytic Disorders and Treatments
- Ubiquitin and proteasome pathways
- CNS Lymphoma Diagnosis and Treatment
- Skin Diseases and Diabetes
- Multiple Myeloma Research and Treatments
- Infectious Diseases and Tuberculosis
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Tumors and Oncological Cases
- DNA Repair Mechanisms
- Cancer and Skin Lesions
- Autoimmune and Inflammatory Disorders
- Urticaria and Related Conditions
- Inflammatory Myopathies and Dermatomyositis
- Immunodeficiency and Autoimmune Disorders
- Peptidase Inhibition and Analysis
- Leprosy Research and Treatment
- Dermatological and Skeletal Disorders
Peking University First Hospital
2016-2021
Peking University
2016-2021
National Clinical Research Center for Digestive Diseases
2020-2021
MRC Laboratory of Molecular Biology
2007
University of Southern California
1982
Southern California University for Professional Studies
1982
Abstract Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma, undergo large-cell transformation (LCT) in late stage, manifesting aggressive behavior, resistance to treatments, and poor prognosis, but mechanisms involved remain unclear. To identify molecular driver LCT, we collected tumor samples from 133 MF patients performed whole-transcriptome sequencing on 49 advanced-stage patients, followed by integrated copy number inference genomic hybridization. Tumors with LCT...
Cutaneous T cell lymphoma is a generally indolent disease derived from skin-homing mature cells. However, in advanced stages, cutaneous may manifest aggressive clinical behaviour and lead to poor prognosis. The mechanism of progression remains unknown. This study, based on large cohort, found that IKZF2, an essential transcription factor during development differentiation, showed stage- dependent overexpression the malignant cells mycosis fungoides lesions. IKZF2 specifically over- expressed...