A5101536987- Cancer Mechanisms and Therapy
- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Fungal Infections and Studies
- Viral-associated cancers and disorders
- Monoclonal and Polyclonal Antibodies Research
- Nuclear Receptors and Signaling
- Vascular Tumors and Angiosarcomas
- Viral Infections and Vectors
- Market Dynamics and Volatility
- Cell Adhesion Molecules Research
- Digital Filter Design and Implementation
- Viral Infectious Diseases and Gene Expression in Insects
- Dermatologic Treatments and Research
- Vascular Malformations and Hemangiomas
- Macrophage Migration Inhibitory Factor
- Protein purification and stability
- Phagocytosis and Immune Regulation
- Psoriasis: Treatment and Pathogenesis
- Cytomegalovirus and herpesvirus research
- Chemokine receptors and signaling
- Complement system in diseases
- Amoebic Infections and Treatments
- Advanced Data Compression Techniques
- Infectious Disease Case Reports and Treatments
Baoji City Central Hospital
2024
Beijing Tsinghua Chang Gung Hospital
2023-2024
Tsinghua University
2024
National Clinical Research Center for Digestive Diseases
2021-2023
Peking University First Hospital
2021-2023
Peking University
2021-2023
University of California, San Diego
2023
University at Buffalo, State University of New York
2019-2021
Fudan University Shanghai Cancer Center
2014-2017
University of California, Santa Barbara
2013
Abstract Cutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin distinguished by the presence clonal malignant cells. The heterogeneity cells and complex tumor microenvironment remain poorly characterized. With single-cell RNA analysis bulk whole-exome sequencing on 19 skin lesions from 15 CTCL patients, we decipher intra-tumor inter-lesion diversity patients propose multi-step evolution model. We further establish subtyping scheme based molecular features their...
BACKGROUNDImmune checkpoint blockade is an emerging treatment for T cell non-Hodgkin's lymphoma (T-NHL), but some patients with T-NHL have experienced hyperprogression undetermined mechanisms upon anti-PD-1 therapy.METHODSSingle-cell RNA-Seq, whole-genome sequencing, whole-exome and functional assays were performed on primary malignant cells from a patient advanced cutaneous who treatment.RESULTSThe was enrolled in clinical trial of therapy disease hyperprogression. Single-cell RNA-Seq...
In this study, we evaluated the effect of size on tumor disposition protein therapeutics, including plasma and pharmacokinetics (PK) trastuzumab (∼150 kDa), FcRn-nonbinding F(ab)<sub>2</sub> fragment (∼100 Fab (∼50 scFv (∼27 kDa) in both antigen (i.e., HER2)-overexpressing (N87) antigen-nonexpressing (MDA-MB-468) tumor-bearing mice. The observed data were used to develop maximum uptake versus molecular weight tumor-to-plasma area under curve (AUC) ratio relationships. Comparison PK different...
Receptor-mediated transcytosis (RMT) is used to enhance the delivery of monoclonal antibodies (mAb) into central nervous system (CNS). While binding endogenous receptors on brain capillary endothelial cells (BCECs) may facilitate uptake mAbs in brain, a strong affinity for receptor hinder efficiency transcytosis. To quantitatively investigate effect pharmacokinetics (PK) anti-transferrin (TfR) different regions rat we conducted microdialysis study directly measure concentration free at sites...
Importance There are limited prognostic statistics and data available on survival outcomes for patients with mycosis fungoides (MF) in Asia. Objective To determine the factors of MF among a cohort China. Design, Setting, Participants This was retrospective study who received treatment at tertiary referral center skin lymphoma (Peking University First Hospital, Beijing, China) from August 1, 2009, to 31, 2021. Data were analyzed September 2021, December 2022. Main Outcomes Measures Overall...
Abstract Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma, undergo large-cell transformation (LCT) in late stage, manifesting aggressive behavior, resistance to treatments, and poor prognosis, but mechanisms involved remain unclear. To identify molecular driver LCT, we collected tumor samples from 133 MF patients performed whole-transcriptome sequencing on 49 advanced-stage patients, followed by integrated copy number inference genomic hybridization. Tumors with LCT...
Due to its aggressiveness and unusual resistance conventional therapies, pancreatic cancer is a highly lethal gastrointestinal malignancy with poor prognosis. According the stem cell hypothesis, there exists fraction of cells, that is, responsible for tumor maintenance therapeutic failure. Herein we investigated involvement proto-oncogene Pim-3 in driving stemness properties cancer. Expression levels several stemness-associated markers were examined lines. The double positive (CD24+ESA+)...
Cutaneous T cell lymphoma is a generally indolent disease derived from skin-homing mature cells. However, in advanced stages, cutaneous may manifest aggressive clinical behaviour and lead to poor prognosis. The mechanism of progression remains unknown. This study, based on large cohort, found that IKZF2, an essential transcription factor during development differentiation, showed stage- dependent overexpression the malignant cells mycosis fungoides lesions. IKZF2 specifically over- expressed...
Xanthogranulomatous orchitis is a chronic, non-neoplastic inflammation that quite rare. In this paper, we discuss the case of 79-year-old male patient who presented with bilateral scrotum swelling and dysuria persisted for two weeks. Despite weeks anti-infection treatment, patient's symptoms persisted, leading to decision perform transurethral prostate resection orchiectomy after careful consideration. After surgery, postoperative pathology indicated had xanthogranulomatous on left side...
Abstract Objective Narrowband ultraviolet B (NB‐UVB) has been recommended as first‐line therapy for early‐stage mycosis fungoides (MF) in international guidelines. NB‐UVB can be used monotherapy or part of a multimodality treatment regimen. There is limited evidence on the effectiveness and optimal patients combination with systemic therapies MF. We aimed to assess versus MF if plaque lesion status was related these effects. Methods This observational cohort study included 247 who had...
Abstract Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous sarcoma characterized by the COL1A1‐PDGFB fusion gene. This study utilized single‐cell RNA sequencing to dissect cellular and molecular landscape of primary DFSP. Distinct DFSP cell clusters, exhibiting fibroblast‐like traits, revealed variations in pathways associated with proliferation, inflammation metabolism. Differential gene expression analysis during differentiation from tumour stem cells unveiled SMOC2, DCN TGFBR3 as...
Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
<p>PDF - 59KB, Quantitative RT-PCR analyses for Pim-1, Pim-2, and Pim-3.</p>
<p>PDF - 30KB, Supplementary Materials an Methods including antibody, patient and tissue samples, scoring of TCTP, a Pim-3 in human pancreatic cancer tissues section.</p>
To observe the clinical therapeutic effect of intense pulsed light PhotoDerm (IPL PhotoDerm) for vascular dermatosis and analysis possible factors affecting effect. Treat all blank kinds 85 cases with IPL PhotoDerm, no obvious side - effects dermatosis. The cure rate telangiectasis, arterial spider nevus, strawberry avermrus uemongioma nevus flammeus is respective 76.5%, 91.7%, 88.9%, 27.8%, 15%, in three times 35.3%, 66.7%, 5.6% 5%. 6 eases appear pigmentation, pigment subsidence or...