A5073686749- Monoclonal and Polyclonal Antibodies Research
- Protein purification and stability
- HER2/EGFR in Cancer Research
- Radiopharmaceutical Chemistry and Applications
- Analytical Chemistry and Chromatography
- Phosphodiesterase function and regulation
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Biosensing Techniques and Applications
- Wound Healing and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Advanced Drug Delivery Systems
- Analytical Methods in Pharmaceuticals
- Cholinesterase and Neurodegenerative Diseases
- Biosimilars and Bioanalytical Methods
- Genomics and Phylogenetic Studies
- Pharmacology and Obesity Treatment
- Ferrocene Chemistry and Applications
- Veterinary medicine and infectious diseases
- Sesquiterpenes and Asteraceae Studies
- Curcumin's Biomedical Applications
- Glycosylation and Glycoproteins Research
- Plant Toxicity and Pharmacological Properties
- Traditional Chinese Medicine Studies
- Pulmonary Hypertension Research and Treatments
- Occupational and environmental lung diseases
University at Buffalo, State University of New York
2015-2024
Sun Yat-sen University
2019-2024
First Affiliated Hospital of Henan University of Science and Technology
2024
Guangxi Academy of Sciences
2024
Chongqing Institute of Green and Intelligent Technology
2023
Second Affiliated Hospital of Xi'an Jiaotong University
2022
Zhengzhou University
2020
Dalian Medical University
2020
University Hospital of Zurich
2019
Jiaxing University
2018
Biodistribution coefficients (BC) allow estimation of the tissue concentrations proteins based on plasma pharmacokinetics. We have previously established BC values for monoclonal antibodies. Here, this concept is extended by development a relationship between protein size and values. The was built deriving various antibody fragments known molecular weight from published biodistribution studies. found that there exists simple exponential allows prediction distribution alone. validated priori...
The use of human aging markers, which are physiological, biochemical and molecular indicators structural or functional degeneration associated with aging, is the fundamental basis individualized assessments. Identifying methods for selecting markers has become a primary vital aspect research. However, there no clear consensus uniform principle on criteria screening markers. Therefore, we combine previous research from our center summarize in population studies, discussed three aspects:...
In this study, we evaluated the effect of size on tumor disposition protein therapeutics, including plasma and pharmacokinetics (PK) trastuzumab (∼150 kDa), FcRn-nonbinding F(ab)<sub>2</sub> fragment (∼100 Fab (∼50 scFv (∼27 kDa) in both antigen (i.e., HER2)-overexpressing (N87) antigen-nonexpressing (MDA-MB-468) tumor-bearing mice. The observed data were used to develop maximum uptake versus molecular weight tumor-to-plasma area under curve (AUC) ratio relationships. Comparison PK different...
Antibody-drug conjugates (ADCs) employ overexpressed cell surface antigens to deliver cytotoxic payloads inside cancer cells. However, the relationship between target expression and ADC efficacy remains ambiguous. In this manuscript, we have addressed a part of ambiguity by quantitatively investigating effect antigen levels on exposure within Trastuzumab-valine-citrulline-monomethyl auristatin E was used as model ADC, four different lines with diverse human epidermal growth factor receptor 2...
Optimization efforts were devoted to discover novel PDE10A inhibitors in order improve solubility and pharmacokinetics properties for a long-term therapy against pulmonary arterial hypertension (PAH) starting from the previously synthesized inhibitor A. As result, potent highly selective inhibitor, 14·3HCl (half maximal inhibitory concentration, IC50 = 2.8 nmol/L >3500-fold selectivity) exhibiting desirable metabolic stability with remarkable bioavailability of 50% was identified aid...
To identify phosphodiesterase-9 (PDE9) as a novel target for the treatment of vascular dementia (VaD), series pyrazolopyrimidinone analogues were discovered based on hit 1. Hit-to-lead optimization resulted in potent inhibitor 2 with excellent selectivity and physicochemical properties to enable vivo studies. Oral administration (5.0 mg/kg) caused notable therapeutic effects VaD mouse model, providing promising lead or chemical probe investigating biological functions PDE9 inhibition.
While going deeper has been witnessed to improve the performance of convolutional neural networks (CNN), smaller for CNN received increasing attention recently due its attractiveness mobile/embedded applications. It remains an active and important topic how design a small network while retaining large deep CNNs (e.g., Inception Nets, ResNets). Albeit there are already intensive studies on compressing size CNNs, considerable drop is still key concern in many designs. This paper addresses this...
Abstract The aims of this work were to define the role androgens in female wound healing and develop characterize a novel dressing with antiandrogens. Androgens retard males, but their has not been established. To understand androgen receptor (AR)‐mediated actions male healing, we utilized global AR knockout (ARKO) mouse model, mutated deleting second zinc finger disrupt DNA binding transcriptional activation. inactivation enhanced rate males by increasing re‐epithelialization collagen...