A5100374686- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Liver Disease Diagnosis and Treatment
- Advanced Nanomaterials in Catalysis
- Respiratory viral infections research
- Aquatic Ecosystems and Phytoplankton Dynamics
- Salmonella and Campylobacter epidemiology
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Virology and Viral Diseases
- Air Quality and Health Impacts
- Urinary Tract Infections Management
- Antibiotic Resistance in Bacteria
- Herpesvirus Infections and Treatments
- Viral Infections and Immunology Research
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Neonatal and Maternal Infections
- Traditional and Medicinal Uses of Annonaceae
- Analytical chemistry methods development
- Genetic Associations and Epidemiology
- Autophagy in Disease and Therapy
- Immune responses and vaccinations
- Streptococcal Infections and Treatments
- Freezing and Crystallization Processes
Guangxi University
2021-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2015-2025
Wenzhou Medical University
2015-2025
Guangxi University of Chinese Medicine
2021-2025
Dalian Polytechnic University
2025
Beijing University of Chemical Technology
2024
Yunnan University of Traditional Chinese Medicine
2024
Shanghai University of Traditional Chinese Medicine
2013-2023
Sichuan University
2019-2023
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2013-2023
As one of the major tools for and by chemical science, biochemical analysis is becoming increasingly important in fields like clinical diagnosis, food safety, environmental monitoring, development chemistry biochemistry. The advancement nanotechnology boosts analytical chemistry, particularly nanoparticle (NP)-based approaches assays. Functional NPs can greatly improve performance because they accelerate signal transduction, enhance intensity, enable convenient readout due to their unique...
This study aimed to explore the role of lncRNA GAS5 in regulation killing effect NK cells on liver cancer. Compared with a control group, GAS5, RUNX3, and NCR1 were down-regulated patients cancer, whereas miR-544 expression was up-regulated Activated had higher IFN-γ level. Knockdown activated decreased secretion, cell cytotoxicity, percentage CD107a+ cells, apoptosis rate HepG2 Huh7 cells. We also proved interaction miR-544, negative miR-544. overexpression increased RUNX3 expression, while...
The Infectious Disease Surveillance of Pediatrics (ISPED) program was established in 2015 to monitor and analyze the trends bacterial epidemiology antimicrobial resistance (AMR) children. Clinical isolates were collected from 11 tertiary care children's hospitals China 2016 2020. Antimicrobial susceptibility testing carried out using Kirby-Bauer method or automated systems, with interpretation according Laboratory Standards Institute 2019 breakpoints. A total 288,377 collected, top 10...
Analysis of trace low molecular weight (LMW) proteins in serum using the label-free imaging ellipsometry (IE) immunosensor is still a challenge due to lack an effective signal amplification strategy and serious nonspecific adsorption. Herein we have developed sandwich strategy-mediated IE (SSIE) enable immunodetection LMW protein biomarkers samples. We first found that weak binding affinity insufficient surface amount density ligand are two important factors which hinder detection...
A rapid and sensitive competitive fluorescence-linked immunosorbent assay (cFLISA) based on quantum dot−streptavidin conjugate (QDs−SA) was developed for the detection of chlorpyrifos in drinking water. The QDs−SA conjugate, which consists 3-mercaptopropyl acid-stabilized CdTe nanoparticle QDs streptavidin (SA) made through active ester method, employed to improve sensitivity QDs−SA-cFLISA. 50% inhibition concentration (IC50) limit (LOD) were 28.5 3.8 ng mL−1, respectively. QDs−SA-cFLISA...
An Au@Ag nanosensor for highly sensitive, qualitative and quantitative immunoassays.
The colorimetric immunoassay based on gold nanoparticles (AuNPs) can hardly enable simultaneous detection of multiple biomarkers in vastly different concentrations (e.g., pg/mL−μg/mL) because its narrow dynamic range. In this work, we demonstrate an with tunable range by using peptide-mediated controlled aggregation surface modification-free AuNPs. Alkaline phosphatase (ALP) removes the phosphate group peptide to yield a positively charged product, which triggers negatively AuNPs and color...
Children with nonalcoholic fatty liver disease (NAFLD) display an altered gut microbiota compared healthy children. However, little is known about the fecal bile acid profiles and their association dysbiosis in pediatric NAFLD. A total of 68 children were enrolled this study, including 32 NAFLD patients 36 Fecal samples collected analyzed by metagenomic sequencing to determine changes NAFLD, ultra-performance liquid chromatography coupled tandem mass spectrometry (UPLC-MS/MS) system was used...
<p dir="ltr">Little is known about the population-based mismatch between phenotypic and genetic BMI (BMI-PGM) its association with type 2 diabetes. We therefore used data from China Kadoorie Biobank UK calculated BMI-PGM for each participant as difference percentile adjusted at baseline polygenic risk score BMI. Participants were categorized into discordantly low (BMI-PGM< 1<sup>st</sup> quartile), <a href="" target="_blank">concordant</a> (the quartile...
This study investigates the digital multimodal composing competence of fifty freshmen from Hong Kong, Macao, and Taiwan regions in a Chinese University based on systemic functional approach to discourse analysis (SF-MDA) sociosemiotic ethnography. These students are divided into six groups required make presentations topics like sports, fashion, festivals, environment, cities. The collected data include students’ texts interview responses. Findings show that a) have awareness salience, but...
In this work, we outline a signal amplification strategy using the coordination chemistry between Fe3+ and poly(glutamic acid) (PGA) for biosensing applications. The theoretical calculation based on density functional theory shows that PGA has much higher binding affinity with than other metal ions. Guided by rationale, prepare PGA-mediated probe through conjugating onto polystyrene (PS) nanoparticles to form brushlike nanostructure coordination. This PGA-PS brush (PPB) large loading...
Renal interstitial fibrosis (RIF), a progressive process affecting the kidneys in chronic kidney disease (CKD), currently lacks an effective therapeutic intervention. Traditional Chinese medicine (TCM) has shown promise reducing RIF and slowing CKD progression. In this study, we demonstrated dose-dependent attenuation of by Ootheca mantidis (SPX), commonly prescribed TCM for CKD, mouse model unilateral ureteral obstruction (UUO). RNA-sequencing analysis suggested that SPX treatment...