A5101413616- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Endometriosis Research and Treatment
- Liver Disease and Transplantation
- Circular RNAs in diseases
- Liver physiology and pathology
- Diet, Metabolism, and Disease
- Synthesis and Biological Evaluation
- Hepatitis C virus research
- Smoking Behavior and Cessation
- Malaria Research and Control
- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- HIV Research and Treatment
- Bioactive Compounds and Antitumor Agents
- Coenzyme Q10 studies and effects
- Coffee research and impacts
- Healthcare Systems and Public Health
- HIV/AIDS drug development and treatment
- School Health and Nursing Education
- Tryptophan and brain disorders
- Viral Infections and Vectors
- Cancer Risks and Factors
- Cytomegalovirus and herpesvirus research
Wenzhou Medical University
2017-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2017-2025
Binzhou University
2020
Binzhou Medical University
2020
This study aimed to explore the role of lncRNA GAS5 in regulation killing effect NK cells on liver cancer. Compared with a control group, GAS5, RUNX3, and NCR1 were down-regulated patients cancer, whereas miR-544 expression was up-regulated Activated had higher IFN-γ level. Knockdown activated decreased secretion, cell cytotoxicity, percentage CD107a+ cells, apoptosis rate HepG2 Huh7 cells. We also proved interaction miR-544, negative miR-544. overexpression increased RUNX3 expression, while...
Of the three unfolded protein response pathways, which are activated by endoplasmic reticulum stress, inositol-requiring enzyme 1α (IRE1α)-X-box-binding 1 (XBP1) signaling is most conserved. These pathways implicated in a variety of types cancer, including hepatocellular carcinoma (HCC). However, role IRE1α-XBP1 development HCC remains unclear. In current study, reverse transcription-quantiative polymerase chain reaction was used to analyze expression levels XBP1 and interleukin (IL)-6 human...
Abstract Background A postmenopausal rise in the rates of nonalcoholic fatty liver disease (NAFLD) has been reported women. This study thus sought to further probe association hysterectomy with NAFLD. Methods The data utilized this investigation were attained from 2017-March 2020 cycle National Health and Nutrition Examination Survey (NHANES), reflecting a strategic utilization comprehensive health nutrition information US population, conduct cross-sectional examination relationship between...
Screen-based behaviours have brought great changes to our lifestyles over the last 50 years. There is limited data evaluating effects of such alterations on prevalence metabolic dysfunction-associated steatotic liver disease (MASLD) in adolescents. This study sets out assess possible associations excessive screen exposure with steatosis a representative sample US cross-sectional analysis used derived from National Health and Nutrition Examination Surveys (NHANES) carried 2017-2018, including...
// Meng-Xiang Lin 1, * , Yong-Xiang Yi 2, Pei-Pei Fang 3 Shan-Shan Huang Chen-Wei Pan Ling-Xiang Jin Tong Zhang 4 and Guang-Yao Zhou 1 Department of Anesthesiology, Critical Care Pain Medicine, The Second Affiliated Hospital Yuying Children's Wenzhou Medical University, Wenzhou, Zhejiang, 325027, P.R. China 2 Hepatobiliary Surgery, Southeast Nanjing, Jiangsu, 210003, Infectious Disease, People's Xinghua, 225700, These authors have contributed equally to this work Correspondence to: Zhou,...
MicroRNA-155 (miR-155) is an important regulator of immune responses in humans. However, its role T-cell activation hepatitis B virus (HBV) infection remains unclear.Eighty-one patients with chronic (CHB), 77 HBV carriers, and 51 healthy controls were recruited. DNA serologic tests carried out for each subject. Levels miR-155 peripheral blood detected by quantitative reverse transcription/polymerase chain reaction. Immune T-cells was determined detection surface molecules CD38 HLA-DR using...
A 60-year-old female patient living in Southeast China presented with persistent fever, chills, night sweats, fatigue, and dizziness of 12-day duration. Blood tests showed neutropenia, thrombocytopenia, active hemolytic anemia, elevated C-reactive protein. Broad-spectrum antibiotics were administered for a possible diagnosis sepsis, without any response. Malaria was initially diagnosed after visualizing intraerythrocytic ring-shaped parasites bone marrow blood smears. The resided an area...
Apoptosis signal-regulating kinase 1 (ASK1) has been reported to induce fibrotic signaling in the setting of oxidative stress. However, role ASK1 and its mechanism action angiotensin II- (Ang II-) induced liver fibrosis remain largely unknown.Human hepatic LX-2 stellate cells were treated with Ang II alone or cotreated plus an inhibitor (GS-4997) siRNA-targeting ASK1. Immunofluorescent staining, real-time PCR, western blotting used determine expressionof α-SMA, Col I, III expression. Cell...
Objective: A/J mice are a mouse model of age-related hearing loss (AHL) with progressive degeneration outer hair cells (OHCs), spiral ganglion neurons (SGNs), and stria vascularis. This study was carried out to observe the otoprotective effects α-lipoic acid on mice. Methods: pups at postnatal day 7 were randomly distributed into untreated group, dimethyl sulfoxide (DMSO) + DMSO group. given intraperitoneally dosage 50 μg/g body weight every other day. Time course auditory-evoked brainstem...
Sterile α motif and histidine/aspartic acid domain‑containing protein 1 (SAMHD1) can inhibit reverse transcription of human immunodeficiency virus‑1 (HIV‑1) by hydrolyzing intracellular deoxy‑ribonucleoside triphosphate. However, its role in HIV‑1 disease progression has not been extensively studied. To study the impacts SAMHD1 on progression, especially DNA levels, we investigated levels peripheral blood elite controllers (ECs), antiretroviral therapy (ART) naive viremic progressors (VPs)...
The application of big data puts forward new requirements for the talent training mode and curriculum reform in higher vocational colleges. Through statistical data, classroom quality can be measured, evaluated traced. Under framework “Internet plus data”, taking cultivation innovative ability as core, realizing multidimensional integration technology science, general knowledge specialty, teaching research, teachers students has become a concept Practice improving talents Obstetrics...