A5015903800- vaccines and immunoinformatics approaches
- Prostate Cancer Treatment and Research
- Enzyme Catalysis and Immobilization
- Ubiquitin and proteasome pathways
- Bacteriophages and microbial interactions
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Computational Drug Discovery Methods
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Poxvirus research and outbreaks
- Cancer, Lipids, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Breast Cancer Treatment Studies
- Education and Learning Interventions
- Amoebic Infections and Treatments
- Nonlinear Optical Materials Studies
- Parasitic Infections and Diagnostics
- Breast Lesions and Carcinomas
- Transgenic Plants and Applications
- Bacterial biofilms and quorum sensing
- Circular RNAs in diseases
- Biochemical and Structural Characterization
Sun Yat-sen University
2020-2025
Beijing University of Chemical Technology
2019-2024
Abdul Wali Khan University Mardan
2022
Guiyang Medical University
2020
Wuhan University
2015-2019
Renmin Hospital of Wuhan University
2015-2019
Affiliated Hospital of Qingdao University
2012
Qingdao University
2012
Hunan University of Humanities, Science and Technology
2009
Center for Excellence in Molecular Cell Science
2007
Cryptosporidium spp., Giardia duodenalis, and Enterocytozoon bieneusi are significant zoonotic protozoa causing gastrointestinal diseases in humans animals. However, their prevalence genotypic characterization ostriches (Struthio camelus) remain poorly understood. This study aimed to investigate the occurrence genetic diversity of these parasites farmed by Yellow River Zhengzhou City, central China. A total 156 fecal samples were collected analyzed using polymerase chain reaction (PCR)...
In this work, we aim to evaluate the trends and cross-country inequalities of global trachoma burden from 1990 2021 project its 2040. This study was a systematic analysis Global Burden Diseases Study (GBD) 2021. Estimates for prevalence disability-adjusted life-years (DALYs) were extracted GBD database. Epidemiological characteristics reported at global, regional, national levels. Trend analysis, decomposition health inequality used. The further projected 2040 via Bayesian age-period-cohort...
Monkeypox virus is an infectious agent that causes fever, Pneumonitis encephalitis, rash, lymphadenopathy and bacterial infection. The current outbreak of monkeypox has reawakened the global health concern. In situation increasing viral infection, no vaccine or drug available for monkeypox. Thus, there urgent need viable development to prevent transmission by boosting human immunity. Herein, using immunoinformatics approaches, a multi-epitope was constructed virus. this connection, B-Cell...
is an opportunistic Gram-negative bacterium implicated in acute and chronic nosocomial infections a leading cause of patient mortality.
The rise of antibiotic-resistant Mycobacterium tuberculosis (Mtb) has reduced the availability medications for therapy, resulting in increased morbidity and mortality globally. Tuberculosis spreads from lungs to other parts body, including brain spine. Developing a single drug can take several decades, making discovery costly time-consuming. Machine learning algorithms like support vector machines (SVM), k-nearest neighbor (k-NN), random forest (RF) Gaussian naive base (GNB) are fast...
Background:: Cancer is recognized globally as the second-most dominating and leading cause of morbidities. Breast cancer most often diagnosed disease in women one causes mortality. In women, 287,850, males, 2710 cases were reported 2022. Approximately 10–20% all new breast United States 2017 triple-negative cancers (TNBCs), which lack expression estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2). Objective:: This study aims to adopt different strategies for...
Borrelia burgdorferi is regarded as an extremely dangerous bacteria causing infectious disease in humans, resulting musculoskeletal pain, fatigue, fever and cardiac symptom. Because of all alarming concerns, no such prophylaxis setup has been available against till now. In fact, vaccine construction using traditional methods so expensive time-consuming. Therefore, considering we designed a multi-epitope-based design silico approaches.To effective safe that can activate cell-mediated humoral...
<h3>Abstract</h3> For decades, a role for the Ca<sup>2+</sup>-binding protein calmodulin (CaM) in Ca<sup>2+</sup>-dependent presynaptic modulation of synaptic transmission has been recognized. Here, we investigated influence CaM on evoked and spontaneous neurotransmission at rod bipolar (RB) cell→AII amacrine cell synapses mouse retina. Our work was motivated by observations that expression RB axon terminals is extremely high [Ca<sup>2+</sup>] normally rises sufficiently to saturate...
We aimed to explore molecular mechanism and drug candidates of vascular toxicities associated with melphalan after treating human retinal endothelial cells (RECs). GSE34381 microarray data was firstly downloaded used identify the differentially expressed genes (DEGs) in REC treated vs. untreated by limma package R language. The transcription network constructed based on TRANSFAC database top five factors (TFs) were select a measure regulatory impact factor, followed construction function...
The present study aimed to identify biomarkers for peroxidasin (Pxdn) mutation-induced eye disorders and the underlying mechanisms involved in this process. microarray dataset GSE49704 was used, which encompasses 4 mouse samples from embryos with Pxdn mutation normal tissues. After data preprocessing, differentially expressed genes (DEGs) between tissues were identified using t-test limma package, followed by functional enrichment analysis. protein-protein interaction (PPI) network...
Abstract Breast cancer is a common malignancy in women which diverse disease. In women, 287,850 and males, 2710 cases are reported 2022. the most often diagnosed disease one of leading causes mortality. Approximately 10-20% all new breast United States 2017 were triple-negative cancers (TNBCs), lack expression estrogen receptors (ER), progesterone (PR), human epidermal growth factor receptor 2 (HER2). Calcium integrin-binding protein1 lacks suitable pocket that could be used to create...
Abstract Background Francisella tularensis is a category A pathogen with the maximum infectious and death rates, demanding development of vaccine. In last eight years, growing interest in F. has resulted generation data about its host binding method. So far, extensive information available, but there no authorized vaccination on market. Method Using silico techniques, present study design to develop multi-epitope From tularensis, B-cell T-cell epitopes were predicted The selection epitope...
Abstract: Scopolamine, as an anticholinergic agent, plays a regulatory role in the peripheral nervous system. In this paper, 6,7-dehydrotropinone, which is key intermediate of scopolamine, synthesized moderate yield through [4+3] cyclization reaction and Barton deoxygenation reaction. This route has good application prospects with mild conditions, yield, simple operating procedures.
Objective To observe the clinical efficacy of intravitreal Conbercept on idiopathic choroidal neovascularization (ICNV). Methods This is an open and prospective study without control trial. Twelve eyes from 11 patients (7 females 4 males) with ICNV diagnosed by best corrected visual acuity (BCVA) , non-contact tonometer, ophthalmoscope, fundus photography, optical coherence tomography (OCT) fluorescein angiography (FFA) were enrolled in this study. All affected treated 0.05 ml (10...