A5103240369- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Computational Drug Discovery Methods
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- HIV/AIDS drug development and treatment
- RNA Research and Splicing
- HIV Research and Treatment
- Nuclear Structure and Function
- Epigenetics and DNA Methylation
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects of Natural Compounds
- NF-κB Signaling Pathways
- Biochemical Analysis and Sensing Techniques
- Acne and Rosacea Treatments and Effects
- Dermatology and Skin Diseases
- Histone Deacetylase Inhibitors Research
- Liver physiology and pathology
- Cybercrime and Law Enforcement Studies
- Multimodal Machine Learning Applications
- melanin and skin pigmentation
- Circular RNAs in diseases
- Genetics and Neurodevelopmental Disorders
Southern Medical University
2019-2025
Nanfang Hospital
2019-2025
Dongguan People’s Hospital
2025
Shenzhen University
2008-2024
Guangzhou Medical University
2024
Second Affiliated Hospital of Guangzhou Medical University
2024
Zhujiang Hospital
2019
University of Notre Dame
2007
Copper (Cu) is an essential trace element whose serum levels have been reported to act as effective indicator of the efficacy radiotherapy. However, little known about role Cu in In this study we aimed determine and investigate precise mechanism by which or Cu-related proteins regulate radiosensitivity hepatocellular carcinoma (HCC).The expression function copper metabolism MURR1 domain 10 (COMMD10) were assessed via a detection assay, immunostaining, real-time PCR, western blot, radiation...
Irradiation has emerged as a valid tool for nasopharyngeal carcinoma (NPC) in situ treatment; however, NPC derived from tissues treated with irradiation is main cause cancer-related death. The purpose of this study to uncover the underlying mechanism regarding tumor growth after and provided potential therapeutic strategy.Fibroblasts were extracted fresh tissue normal mucosa. Immunohistochemistry was conducted measure expression α-SMA FAP. Cytokines detected by protein array chip identified...
The NS5B polymerase is one of the most attractive targets for developing new drugs to block Hepatitis C virus (HCV) infection. We describe discovery novel potent HCV inhibitors by employing a virtual screening (VS) approach, which based on random forest (RB-VS), e-pharmacophore (PB-VS), and docking (DB-VS) methods. In RB-VS stage, after feature selection, model with 16 descriptors was used. PB-VS six energy-based pharmacophore (e-pharmacophore) models from different crystal structures...
Abstract Myocardial dysfunction is a significant complication of sepsis that associated with elevated mortality rates. Transmembrane BAX inhibitor motif containing 1 (TMBIM1), stress‐responsive protein, has garnered interest in the field cardiovascular disease for its cardioprotective properties. Nevertheless, role TMBIM1 on sepsis‐induced cardiac (SICD) remains unknown. Here, our findings revealed elevation expression within myocardium following endotoxin challenge and further demonstrate...
The activity and stability of mushroom tyrosinase were studied in ionic liquid (IL)-containing aqueous systems. effect three ILs ([BMIm][PF6], [BMIm][BF4]), [BMIm][MeSO4], where [BMIm] = 1-butyl-3-methylimidazolium) their inorganic salts (KMeSO4, KPF6, NaBF4) on the enzyme performance was investigated by comparing kinetic (such as Km, Vmax, optimal pH temperature, activation energy) thermostability parameters (including half-lives, deactivation constants, energies for deactivation, ΔG*, ΔH*,...
The Copper Metabolism MURR1 (COMM) domain family has been reported to play important roles in tumorigenesis. As a prototype for the COMMD family, expression pattern and biological function of COMMD6 human tumours remain unknown.COMMD6 BALB/c mice tissues was examined using real-time PCR immunohistochemistry. Kaplan-Meier analysis applied evaluate prognosis tumours. Competing endogenous RNA (ceRNA) transcriptional regulation network were constructed based on differentially expressed mRNAs,...
IFI44 (interferon-induced protein 44), containing a guanosine-5'-triphosphate (GTP) binding domain, was reported to play significant role in immune response autoimmune disease. However, its roles involved cancers remain unclear. Here, we detected the expression of TCGA Pan-cancer and generally explored influence on infiltration tumor microenvironment. The results displayed that mainly located cytoplasm, overexpressed head neck squamous cell carcinoma (HNSC) samples compared with normal...
TRIP13 is a member of the large superfamily AAA + ATPase proteins and associated with variety activities. Emerging evidence has shown that may serve as an oncogene. However, function in breast cancer (BC) not yet been elucidated. Here, bioinformatic tools laboratory experiments were combined to analyse expression patterns, prognostic value functional network BC. Multiple databases immunohistochemistry (IHC) indicated higher BC tissue compared normal tissue. was highly expressed lung...
Abstract Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. Currently, there limited knowledge dysregulation cellular proliferation and apoptosis that contribute to malignant phenotype in HCC. Copper metabolism gene MURR1 domain 10 (COMMD10) initially identified as a suppressor pathogenesis HCC our observations. Here we aimed explore its function prognostic value progression Methods Functional experiments were performed role COMMD10 The...
CHST4 plays an important role in lymphocyte homing and is abnormally expressed several cancer types; however, its precise function tumor development progression unknown. Here we confirm that aberrantly various subtypes. In particular, found expression was downregulated hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) tumors compared to paired normal tissue. We also showed overexpression inhibited the proliferation metastasis of HCC cells vitro. Clinically, identified as...
Glycyrrhetinic acid (GA) is a saponin compound, isolated from licorice (Glycyrrhiza glabra), which has been wildly explored for its intriguing pharmacological and medicinal effects. GA triterpenoid glycoside displaying an array of biological activities, including anti-inflammatory, anti-bacterial, antiviral antioxidative properties. In this study, we investigated the underlying mechanisms on acne vulgaris through network pharmacology proteomics. After intersection 154 drug targets 581...
Abstract Background Spectrin repeat containing nuclear envelope family member 3 (SYNE3) encodes an essential component of the linker cytoskeleton and nucleoskeleton (LINC) complex, namely nesprin-3. In a tumor, invasiveness metastasis rely on integrity LINC while role SYNE3/nesprin-3 in cancer is rarely studied. Methods Here, we explored expression pattern, prognostic value, related mechanisms SYNE3 through both experimental bioinformatic methods. We first detected BALB/c mice, normal human...
Norcarbovir (1) and norabacavir (2), the desmethylene derivatives of anti-HIV agents carbovir abacavir, were efficiently synthesized from a common intermediate 4. Their antitumor antiviral activities evaluated results indicate showed comparable activity to that abacavir.
This study was designed initially to explore the effect of chemoradiotherapy on patients diagnosed with head and neck cancer (HNC) respect alteration systematic immunity.We did a retrospective enrolling received concurrent (CCRT), or without induction chemotherapy (IC). Blood tests were performed before IC, after CCRT. Flow cytometric analysis turbidimetric inhibition immunoassay used for detection.A total number 58 included from April 1, 2018, March 31, 2019. Levels immunoglobulins (Ig),...
The surge in merchant fraud poses a significant threat to market order and consumer security. Effective security monitoring for merchants is crucial safeguarding the digital life ecosystem users' financial well-being. Detecting daily fraudulent payment transactions, challenging task current methods, requires efficient transformation of transactions into embeddings, especially representing based on their behavioral transactions. To address this, we propose Grouping Sampling-based Sequence...
Abstract Treatment of recurrent head and neck squamous cell carcinoma (HNSCC) after radiotherapy (RT) with immune checkpoint inhibitors (ICIs) have attained certain success recently. However, some patients remained progressed the total efficacy was finite, highlighting need to identify new therapeutic options. DFNA5, also called GSDME, could switch chemotherapy drug induced-pyroptosis mediated by caspase-3. Presently, relationship between DFNA5 radiation in HNSCC unclear. Here, we showed...
Abstract Background: Spectrin repeat containing nuclear envelope family member 3 (SYNE3) encodes an important component of linker cytoskeleton and nucleoskeleton (LINC) complex, namely nesprin-3. In tumor, invasiveness metastasis rely on the integrity LINC while role SYNE3/nesprin-3 in cancer is rarely studied. Methods: Here, we explored expression pattern, prognostic value related mechanisms SYNE3 through both experimental bioinformatic methods. We first detected BALB/c mice, normal human...
Background: Hepatocellular carcinoma (HCC) patients diagnosed with the same clinic stage by Barcelona Clinic Liver Cancer (BCLC) system show different prognosis due to coexistence of inflammation and tumor heterogeneity. Here, we aimed seek for inflammation-related molecular biomarkers accurately predicting diagnosis HCC.Methods: In this multicenter retrospective analysis, included 516 HCC from three Chinese hospitals: Nanfang Hospital (Guangzhou, China), Zhujiang China) Yuebei (Shaoguan,...
Background: Pulmonary surfactant protein A1 (SFTPA1) plays a critical role in maintaining lung tissue homeostasis and its disruption could cause diseases even cancer. Despite the finding that not only affected cancer but also contributed to minority extra-pulmonary neoplasm, expression profile molecular mechanism of SFTPA1 pan-cancer remain unclear. As an innate immune regulator inflammatory disease lungs, whether any tumor growth immunotherapeutic response is Methods: The BALB/c mice, human...
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