A5011950328- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Calcium Carbonate Crystallization and Inhibition
- MicroRNA in disease regulation
- Polymer Surface Interaction Studies
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Wound Healing and Treatments
- Bone Metabolism and Diseases
- Cancer, Lipids, and Metabolism
- Bone health and osteoporosis research
- Immune cells in cancer
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Circular RNAs in diseases
- Metabolism, Diabetes, and Cancer
- Ocular Oncology and Treatments
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- Advanced biosensing and bioanalysis techniques
- Inflammatory Biomarkers in Disease Prognosis
- Nanocluster Synthesis and Applications
Zhejiang University
2016-2025
Sir Run Run Shaw Hospital
2021-2025
Blood Center of Zhejiang Province
2021-2025
Henan Normal University
2024
Zhejiang University of Science and Technology
2022-2023
Nanjing Medical University
2020-2022
Jiangsu Province Hospital
2020
Weatherford College
2020
Nanjing University
2020
Nanjing Jiangning Hospital
2020
Biological hard tissues such as bones always contain extremely high levels of citrate, which is believed to play an important role in bone formation well osteoporosis treatments. However, its mechanism on biomineralization not elucidated. Here, it found that the adsorbed citrate molecules collagen fibrils can significantly reduce interfacial energy between biological matrix and amorphous calcium phosphate precursor enhance their wetting effect at early stage, sequentially facilitating...
MicroRNAs (miRNAs) are endogenous small non-coding RNAs that play central roles in diverse pathological processes. In this study, we investigated the effect of microRNA-182 (miR-182) on development posterior uveal melanomas. Initially, demonstrated miR-182 expression was dependent p53 induction melanoma cells. Interestingly, transient transfection into cultured cells led to a significant decrease cell growth, migration, and invasiveness. Cells transfected with cycle G1 arrest increased...
Abstract Osteoporosis is an incurable chronic disease characterized by a lack of mineral mass in the bones. Here, full recovery osteoporotic bone achieved using calcium phosphate polymer‐induced liquid‐precursor (CaP‐PILP). This free‐flowing CaP‐PILP material displays excellent inductivity and able to readily penetrate into collagen fibrils form intrafibrillar hydroxyapatite crystals oriented along c ‐axis. ability attributed microstructure material, which consists homogeneously distributed...
Abstract Diabetic wound is a significant challenge for clinical treatment with high morbidity and mortality. Plenty of hydrogels good biocompatibility have been widely used in diabetic healing. However, most them cannot be directly absorbed utilized by the wounds, which prolongs regeneration time. Here new type healing hydrogel developed that based on histidine, natural dietary essential amino acid tissue formation. The cross‐linked zinc ions (Zn 2+ ) sodium alginate (SA) via dynamic...
Tumor-associated macrophages, especially M2-like are extensively involved in tumor growth and metastasis, suppressing the innate immunity to help cells escape reshaping microenvironment metastatic grow. However, vivo, real-time visualized migration of macrophages has never been explored monitor metastasis process. Herein, we prepared an macrophage-targeting nitric oxide (NO)-responsive nanoprobe (NRP@M-PHCQ) consisting amphiphilic block copolymer with mannose hydroxychloroquine (HCQ)...
Reactive Oxygen Species (ROS) refers to a highly reactive class of oxidizing species that have the potential induce cellular apoptosis and necrosis. Cuproptosis, type cell death, is primarily associated with effects copper ions. However, specific relationship between ROS, cuproptosis, osteosarcoma (OS) remains relatively unexplored. Additionally, there limited research on use cuproptosis in conjunction oxidative stress for treating OS inhibiting tumor-induced bone destruction. To address...
Abstract The repair of hierarchical osteochondral defects requires complex gradient reconstruction at different levels, with continuous‐gradient mineralization being crucial. Strategies for achieving have rarely been reported. Here, a mineralized hydrogel is prepared using simple gravitational osmosis ≈2 nm amorphous calcium phosphate nanocluster (ACPC) suspension into composite organic frameworks regeneration. During infiltration, ACPC underwent gradual mineralization, resulting in the...
Rationale: Physical exercise is essential for skeletal integrity and bone health. The gut microbiome, as a pivotal modulator of overall physiologic states, closely associated with homeostasis metabolism. However, the potential role intestinal microbiota in exercise-mediated gain remains unclear. Methods: We conducted depletion fecal transplantation (FMT) ovariectomy (OVX) mice aged to investigate whether transfer ecological traits could confer exercise-induced protective effects. study...
Postmenopausal osteoporosis (PMOP) is a chronic systemic bone metabolism disorder. Promotion in the patterns of human marrow mesenchymal stem cells (hBMSCs) differentiation towards osteoblasts contributes to alleviating osteoporosis. Aucubin, natural compound isolated from well-known herbal medicine Eucommia, was previously shown possess various pharmacological effects. However, its effects on hBMSCs PMOP patients are unknown. The aim this present research investigate impact and underlying...
Abstract Intervertebral disc degeneration (IVDD) is a leading cause of low back pain, with limited effective treatments due to an incomplete understanding disease mechanisms. In this study, we report that circFUNDC1, nuclear circular RNA, markedly downregulated in nucleus pulposus cells (NPCs) from patients end-stage IVDD. CircFUNDC1 derived the gene encoding FUN14 domain-containing 1 (FUNDC1) protein, which essential for mitophagy and cell survival. Functional analyses reveal circFUNDC1...
Osteoporosis results from an imbalance between bone formation and resorption. Traditional drugs for treating osteoporosis are associated with serious side effects, thus, new treatment methods required. This study investigated the role of differentially expressed microRNAs during osteoclast differentiation activity osteoarthritis as well underlying mechanisms. We used a microarray to screen that decreased in process verified miR-21-5p decrease significantly using RT-qPCR. In follow-up...
Abstract Cervical squamous cell carcinoma (CSCC) is a type of female cancer that affects millions families worldwide. Human papillomavirus (HPV) infection the main reason for CSCC formation, and intraepithelial lesions (SILs) induced by high-risk HPV (HR-HPV) are considered precancerous lesions. A previous study reported HPV-infected cells were able to counteract lipid peroxidation survival. Recent research has ferroptosis acts in an iron-dependent manner kill cells, it proposed as new...
Therapeutic bioengineering based on stem cell therapy holds great promise in biomedical applications. However, the application of this treatment is limited orthopedics because their poor survival, weak localization, and low retention. In work, magneto-mechanical bioengineered cells consisting magnetic silica nanoparticles (MSNPs) mesenchymal (MSCs) are prepared to alleviate osteoporosis. The MSCs with spatial retention, directional tracking capabilities could be mediated by a guided field...
Bone is a hierarchical tissue in which the extracellular matrix consists of hydroxyapatite (HAP) crystals embedded collagen matrix. Artificial bone regeneration remains great challenge due to difficulty balancing chemical composition, biological compatibility, and mechanical performance implant. Biomineralization starts from formation hydrogel-like biomacromolecule many cases, while mineralization HAP often builds amorphous calcium phosphate (ACP) nanoclusters. Inspired by these discoveries,...
Peptide-based immune checkpoint inhibitors exhibit remarkable therapeutic benefits although their application is hindered by quick blood clearance and low affinity with receptors. The modification of the peptides into artificial antibodies an ideal platform to solve these problems, one optional pathways conjugation a polymer. More importantly, bridging effect, mediated bispecific antibodies, could promote interaction cancer cells T cells, which will benefit immunotherapy. Herein,...
Hydrogels have been widely used in various biomedical applications, including skin regeneration and tissue repair. However, the capability of certain hydrogels to absorb exudate or blood from surrounding wounds, coupled with challenge their long-term storage prevent bacterial growth, can pose limitations efficacy biological applications. To address these challenges, development a multifunctional aloin-arginine-alginate (short for 3A) bio-patch capable transforming into hydrogel upon...
Bone is a complex organic–inorganic composite tissue composed of ∼30% organics and ∼70% hydroxyapatite (HAp). Inspired by this, we used 30% collagen 70% HAp extracted from natural bone using the calcination method to generate biomimetic hydrogel scaffold (BBCHS). In one respect, BBCHS, with fixed proportion inorganic organic components similar bone, exhibits good physical properties. another highly biologically active biocompatible effectively promotes osteogenic differentiation, type I...
Aggregation-based crystal growth is distinct from the classical understanding of solution crystallization. In this study, we reveal that N-stearoyl-l-glutamic acid (C18-Glu, an amphiphile mimics a biomineralization-relevant biomolecule) can switch calcite crystallization ion-by-ion to non-classical particle-by-particle pathway, which combines and in one system. This mechanism change controlled by concentration ratio [C18-Glu]/[Ca(2+)] solution. The high stabilize precursor nanoparticles...