A5101286925- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Advanced Nanomaterials in Catalysis
- Osteoarthritis Treatment and Mechanisms
- Advanced biosensing and bioanalysis techniques
- Spine and Intervertebral Disc Pathology
- Diabetic Foot Ulcer Assessment and Management
- Bone Tissue Engineering Materials
- Pressure Ulcer Prevention and Management
- Nanoparticle-Based Drug Delivery
- Spinal Cord Injury Research
- Spinal Hematomas and Complications
- Advanced Drug Delivery Systems
- Protease and Inhibitor Mechanisms
- Biomarkers in Disease Mechanisms
- Wound Healing and Treatments
- Graphene and Nanomaterials Applications
- MXene and MAX Phase Materials
- Bone Metabolism and Diseases
- Mesenchymal stem cell research
Sir Run Run Shaw Hospital
2023-2024
Zhejiang University
2023-2024
Qingdao University
2024
Qingdao Municipal Hospital
2024
Blood Center of Zhejiang Province
2024
Catalytic tumor therapy based on two-dimensional (2D) nanomaterials is a burgeoning and promising therapeutic modality. However, the inefficient utilization conversion of exogenous stimulation, single catalytic modality, unsatisfactory efficiency in microenvironment (TME) have seriously restricted their further application therapy. Herein, heterogeneous carbon nitride-based nanoagent named T-HCN@CuMS was successfully developed, which dramatically improved Benefiting from donor–acceptor...
Reactive Oxygen Species (ROS) refers to a highly reactive class of oxidizing species that have the potential induce cellular apoptosis and necrosis. Cuproptosis, type cell death, is primarily associated with effects copper ions. However, specific relationship between ROS, cuproptosis, osteosarcoma (OS) remains relatively unexplored. Additionally, there limited research on use cuproptosis in conjunction oxidative stress for treating OS inhibiting tumor-induced bone destruction. To address...
Intervertebral disc degeneration (IDD) is a prevalent degenerative disorder that closely linked to aging.Numerous studies have indicated the crucial involvement of autophagy in development IDD.However, non-selective nature substrates poses great limitations on application autophagy-related medications.This study aims enhance our comprehension IDD and investigate novel therapeutic approach from perspective selective receptor NBR1.Proteomics immunoprecipitation mass spectrometry analysis,...
The incidence of osteochondral defects caused by trauma, arthritis or tumours is increasing annually, but progress has not been made in terms treatment methods. Due to the heterogeneous structure and biological characteristics cartilage subchondral bone, integration repair still a challenge.
The critical-sized bone defect resulting from trauma, tumor resection, and congenital deformity fails to undergo spontaneous healing due its substantial size, while the ensuing inflammatory process hypoxic environment further impede regenerative process. Therefore, it has consistently presented a significant clinical challenge. In present study, we incorporate glycyrrhizic acid (GA)-functionalized hydrogel onto surface of Hydroxyapatite (Hap)-modified Polycaprolactone (PCL) scaffold...
Abstract Post‐surgical recurrence and extensive bone defects pose significant challenges during osteosarcoma treatment. These issues can be addressed using a novel strategy that promotes repair after removing residual tumors. Therefore, 3D‐printed porous polylactic acid (PLA) scaffold (PH‐GBS@CCP) filled with hydrogel surface‐modified nano‐hydroxyapatite (nHA) is designed. The hydrogel, composed of gelatin modified methacrylic anhydride (GelMA), sodium alginate (SA), borax, contains...