A5074443501- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Luminescence and Fluorescent Materials
- Spine and Intervertebral Disc Pathology
- Pressure Ulcer Prevention and Management
- Wound Healing and Treatments
- Pain Mechanisms and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Immune Response and Inflammation
- Tendon Structure and Treatment
- Bone Tissue Engineering Materials
- Nerve injury and regeneration
- NF-κB Signaling Pathways
- interferon and immune responses
- Musculoskeletal pain and rehabilitation
- Extracellular vesicles in disease
Sir Run Run Shaw Hospital
2021-2024
Zhejiang University
2021-2024
Inflammatory responses of nucleus pulposus (NP) can induce imbalanced anabolism and catabolism extracellular matrix, the cytosolic dsDNA accumulation STING-NF-κB pathway activation found in NP inflammation are considered as fairly important cause intervertebral disc (IVD) degeneration. Herein, we constructed a siSTING delivery hydrogel aldehyde hyaluronic acid (HA-CHO) poly(amidoamine) PAMAM/siRNA complex to intervene abnormal STING signal for IVD degeneration treatment, where formation...
Abstract Chronic inflammatory diseases, such as intervertebral disc degeneration (IVDD), which affect the lives of hundreds millions people, still lack effective and precise treatments. In this study, a novel hydrogel system with many extraordinary properties is developed for gene–cell combination therapy IVDD. Phenylboronic acid‐modified G5 PAMAM (G5‐PBA) first synthesized, therapeutic siRNA silencing expression P65 mixed G5‐PBA (siRNA@G5‐PBA) then embedded into (siRNA@G5‐PBA@Gel) based on...
Developing smart hydrogels with integrated and suitable properties to treat intervertebral disc degeneration (IVDD) by minimally invasive injection is of high desire in clinical application still an ongoing challenge. In this work, extraordinary injectable hydrogel PBNPs@OBG (Prussian blue nanoparticles@oxidized hyaluronic acid/borax/gelatin) promising antibacterial, antioxidation, rapid gelation, self-healing characteristics was designed via dual-dynamic-bond cross-linking among the...
Abstract Post‐surgical recurrence and extensive bone defects pose significant challenges during osteosarcoma treatment. These issues can be addressed using a novel strategy that promotes repair after removing residual tumors. Therefore, 3D‐printed porous polylactic acid (PLA) scaffold (PH‐GBS@CCP) filled with hydrogel surface‐modified nano‐hydroxyapatite (nHA) is designed. The hydrogel, composed of gelatin modified methacrylic anhydride (GelMA), sodium alginate (SA), borax, contains...