A5101492655- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Cold Atom Physics and Bose-Einstein Condensates
- Pharmacological Effects of Natural Compounds
- RNA Research and Splicing
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glycosylation and Glycoproteins Research
- Cancer-related gene regulation
- Neonatal and Maternal Infections
- CRISPR and Genetic Engineering
- Pregnancy-related medical research
- Natural product bioactivities and synthesis
- RNA regulation and disease
- Neuroblastoma Research and Treatments
- Quantum, superfluid, helium dynamics
- Streptococcal Infections and Treatments
- Virus-based gene therapy research
- Chemical Reactions and Isotopes
- Cancer, Hypoxia, and Metabolism
- Bone Metabolism and Diseases
- Helicobacter pylori-related gastroenterology studies
- 14-3-3 protein interactions
Albany Medical Center Hospital
2024
Fudan University
2023
Zhongshan Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Sichuan Center for Disease Control and Prevention
2022
Blood Center of Zhejiang Province
2021
Sir Run Run Shaw Hospital
2020-2021
Zhejiang University
1996-2021
Third Xiangya Hospital
2021
Central South University
2021
LncRNA SNHG5 promotes growth and invasion in melanoma by regulating the miR-26a-5p/TRPC3 pathway Jun Gao,1,2 Kang Zeng,1 Yi Liu,3 Lin Gao,4 Lishi Liu1 1Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, China; 2Department Liuzhou Worker's Liuzhou, 3Department Hand Foot Surgery, 4Department Clinical Research Center, The 2nd Medicine College (Shenzhen People's Hospital) Jinan Shenzhen, China Introduction: Melanoma has been reported as most common malignancy...
Lung cancer is the leading cause of cancer-associated mortality worldwide. Increasing evidence has found that metabolism alternations represent a critical hallmark for lung cancer. There an urgent requirement to understand and dissect molecular mechanisms underlying therapy. It remains largely unknown whether deregulation miRNAs contributes metabolism. The present study aimed investigate role miR-144 in Glucose uptake rate lactate production assays demonstrated expression decreased therefore...
Abstract This study examined bone morphogenetic protein 2 ( BMP2 ) expression in oral squamous cell carcinoma (OSCC) and its effects on the biological behavior of OSCC cells, along with potential underlying mechanisms. was analyzed using mRNA data from The Cancer Genome Atlas Genomics Expression Omnibus Database (GEO). SCC9 cells were transfected vitro small interfering RNA targeting (si-BMP2), a negative control sequence (si-NC), plasmid, or empty plasmid (vector). After transfection, Cell...
Osteoporosis results from an imbalance between bone formation and resorption. Traditional drugs for treating osteoporosis are associated with serious side effects, thus, new treatment methods required. This study investigated the role of differentially expressed microRNAs during osteoclast differentiation activity osteoarthritis as well underlying mechanisms. We used a microarray to screen that decreased in process verified miR-21-5p decrease significantly using RT-qPCR. In follow-up...
Claudin 18 (CLDN18) is a transmembrane protein that localizes to apical regions form tight junction complexes. Abnormal expression of CLDN18 has been reported in gastric cancer (GC). The expression, genetic alterations, and prognostic role were analyzed using public data from Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Human Protein (HPA) databases multiple online tools. biological network was determined GeneMANIA. restricted lung stomach normal tissues, significantly...
Objectives: The aim of the study was to observe effect antisense hypoxia-inducible factor 1α (HIF-1α) on progression, metastasis, and chemosensitivity pancreatic cancer. Methods: BxPc-3 cells transfected with HIF-1α plasmid were exposed 0.5% O2 for 4 hours. Expressions HIF-1α, survivin, β1 integrin detected by reverse transcriptase -polymerase chain reaction Western blotting. Growth inhibition rates apoptosis under different dosages chemotherapy agents (5-fluorouracil, doxorubicin,...
Osteoarthritis (OA) is a degenerative joint disease. Currently, apart from symptomatic treatment or replacement, no other effective treatments for OA exist. The mechanisms underlying remain elusive and require further research. Circular RNAs (circRNAs) are known to be involved in many diseases; however, their function not yet fully understood. Here, we identified novel circRNA, Circ0083429. role of Circ0083429 was confirmed via western blot (WB), quantitative real-time PCR (qRT-PCR),...
Glioma-specific transcription of tumor-killing genes has been exploited as a promising gene therapeutic modality in glioma patients. Musashi1 (Msi1) and GFAP promoters are both cancer-specific promoters. Optimized HIF-binding site (optHBS) sequence was newly found efficient EPO HREs used enhancer cancer therapy. We constructed 4optHBS-Msi1/GFAP tested their ability to mediate BAX expression induce apoptosis cell lines. Our results demonstrated that apparently strong glioma-selective with...
In the present study, a series of experiments were conducted to explore function miR-374b and regulatory relationship among miR-374b, GATA3 SEMA3B in glioma.MiR-374b mimics inhibitors employed regulate expression.Besides, qRT-PCR assay was used for detecting expression level mRNAs.To verify targeting between GATA3, dual luciferase analysis utilized.Moreover, chromatin immunoprecipitation (ChIP) performed identify correlation with SEMA3B.Furthermore, si1-GATA3, si2-GATA3 pc-GATA3 pc-SEMA3B...
Abstract The molecular mechanism underlying the development of intervertebral disc disease (IVDD) is not completely understood. Circular RNAs (circRNAs) play a significant role in occurrence and various diseases, studies have shown that circPKNOX1 involved compensatory response extracellular matrix synthesis secretion nucleus pulposus (NP) cells. However, through which circRNAs regulate IVDD progression remains unclear; therefore, this study, we explored significance IVDD. expression NP...
Abstract Background Intrahepatic cholangiocarcinoma (iCCA) is a highly heterogeneous and lethal hepatobiliary tumor with few therapeutic strategies. The metabolic reprogramming of cells plays an essential role in the development tumors, while molecular classification iCCA largely unknown. Here, we performed integrated multiomics analysis to depict differences characteristics patients, hoping provide novel perspective understand treat iCCA. Methods We 116 samples, including whole‐exome...
Prevailing evidences have demonstrated that circular RNAs (circRNAs) are closely associated with various stages of carcinogenesis. However, very few studies delineated the specific mechanism association between circRNAs and osteosarcoma (OS). It offers a novel insight can be explored as potential therapeutic strategy for OS.In this study, circTUBGCP3 was chosen from existing reported circRNA microarray data obtained OS cell lines normal bone cells. Subsequently, qRT-PCR performed to...

 Purpose: To investigate the effect of azaindole on proliferation liver cancer cells, as well underlying mechanism.
 Methods: Colony forming and 3-(4,5-dimethylthiazole-2-yl)-2,5-biphenyl tetrazolium bromide (MTT) assays were used to determine cell proliferation. A tumor model was established through subcutaneous administration HEPG2 cells rats. Thereafter, in vivo development measured using Vernier caliper.
 Results: The potential SNU-398 markedly dose-dependently suppressed...
Competence is an important bioprocess for Streptococcus pneumoniae. Previously, we demonstrated that bacterial second messenger cyclic di-adenosine monophosphate (c-di-AMP) modulates pneumococcal competence. Surprisingly, a low c-di-AMP-producing strain, cdaA*, due to mutation in the diadenylate cyclase CdaA, highly susceptible competence-stimulating peptide (CSP). In this study, screened cdaA* suppressor mutations resistant CSP explore c-di-AMP signaling S. A total of 14 clones were...
The generalized invariant theory is used to study the problem of diagonalization time-evolution operator. It shown that there an intimate connection between operator and phase factors. As illustrative example, quantum motion ion in a combined trap investigated; classical correspondence stability are then discussed.
The invariant formulation is used to investigate the quantum motion of an ion in a combined trap. classical correspondence and stability problem are then discussed.