A5100728981- Glycosylation and Glycoproteins Research
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Gene expression and cancer classification
- Plant Reproductive Biology
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Synthesis and biological activity
- dental development and anomalies
- Cancer-related gene regulation
- Hearing, Cochlea, Tinnitus, Genetics
- Biochemical and Molecular Research
- RNA Interference and Gene Delivery
- Plant Molecular Biology Research
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Synthesis and Reactions of Organic Compounds
- Advanced Combustion Engine Technologies
- Ferroptosis and cancer prognosis
- Sulfur Compounds in Biology
- Plant responses to water stress
- Advanced Multi-Objective Optimization Algorithms
- Polysaccharides and Plant Cell Walls
- Quinazolinone synthesis and applications
Ningxia Medical University
2022-2025
Wayne State University
2022-2025
Huazhong University of Science and Technology
2022-2025
North China University of Science and Technology
2022-2025
Nanjing Institute of Technology
2024
Ningxia Hui Autonomous Region Peoples Hospital
2023
Ningxia Medical University General Hospital
2023
Hokkaido University
2020-2023
Taipei Medical University
2013-2023
South China Normal University
2023
Abstract O-GlcNAc modification plays critical roles in regulating the stress response program and cellular homeostasis. However, systematic multi-omics studies on regulated mechanism have been limited. Here, comprehensive data are obtained by a chemical reporter-based method to survey function human breast cancer cells stimulated with genotoxic agent adriamycin. We identify 875 stress-induced chromatin-associated proteins (OCPs), including 88 transcription factors cofactors (OCTFs),...
Abstract A key nutrient sensing process in all animal tissues is the dynamic attachment of O-linked N-acetylglucosamine (O-GlcNAc). Determining targets and roles O-GlcNAc glycoproteins has potential to reveal insights into healthy diseased metabolic states. In cell studies, thousands proteins are known be O-GlcNAcylated, but reference datasets for most tissue types animals lacking. Here, we apply a chemoenzymatic labeling study compile high coverage dataset quadriceps skeletal muscle from...
Patients with malignant biliary obstruction (MBO) are often treated endoscopic retrograde cholangiopancreatography (ERCP) combined stent placement for tumor progression. However, certain patients die within 30 days after the procedure, increasing healthcare resource consumption and patient burden. Therefore, development of early mortality prediction models is important optimizing treatment decisions. The present study retrospectively analyzed clinical data 285 MBO, including demographic...
Abstract This study examined bone morphogenetic protein 2 ( BMP2 ) expression in oral squamous cell carcinoma (OSCC) and its effects on the biological behavior of OSCC cells, along with potential underlying mechanisms. was analyzed using mRNA data from The Cancer Genome Atlas Genomics Expression Omnibus Database (GEO). SCC9 cells were transfected vitro small interfering RNA targeting (si-BMP2), a negative control sequence (si-NC), plasmid, or empty plasmid (vector). After transfection, Cell...
A fundamental mechanism that all eukaryotic cells use to adapt their environment is dynamic protein modification with monosaccharide sugars. In humans, O-linked N-acetylglucosamine (O-GlcNAc) rapidly added and removed from diverse sites as a response fluctuating nutrient levels, stressors, signaling cues. Two aspects remain challenging for tracking functional O-GlcNAc events chemical strategies: spatial control over subcellular locations time during labeling. The objective of this study was...
Proteolipid protein 2 (PLP2) has been shown to be upregulated in several cancers, including breast cancer, hepatocellular carcinoma, osteosarcoma, and melanoma. PLP2 specifically binds phosphatidylinositol 3 kinase activate the B pathway enhance cell proliferation, adhesion, invasion melanoma cells. Therefore, we speculated that exhibits oncogenic potential. However, regulatory mechanisms of cancer cells remain unclear. Herein, found microRNA (miR)-664 expression was significantly...
Objective: This study was conducted for investigating the functions of circular RNA circRNA_100146 (circRNA_100146) in development prostate cancer (PCa) and identifying underlying mechanisms circRNA_100146/miR-615-5p/TRIP13 axis. Materials Methods: Under support RT-PCR, expression PCa cells examined. Cell Counting Kit-8 (CCK-8) assays clone formation were applied to assessment cell proliferation. We then determined invasion migration through transwell wound healing assays. pull-down...
Abstract Background BIRC5 (Survivin), a key member of inhibitor apoptosis family, has been shown in colorectal cancer (CRC) tumorigenesis and progress. This study investigated the expression levels cell free mRNA serum CRC assess its diagnostic prognostic potential. Methods Levels were detected by reverse transcription quantitative real‐time PCR 92 patients 60 healthy volunteers. Results Cell significantly increased ( P < 0.001), correlated with tumor differentiation = 0.035), regional...
Plant growth is significantly altered in response to submergence stress. However, the molecular mechanisms used by seedlings this stress, especially for hypocotyl growth, are largely unknown terrestrial plants such as Arabidopsis thaliana. The microtubule cytoskeleton participates plant cell but it remains unclear whether submergence-mediated involves cytoskeleton. We demonstrated that induced underwater elongation through activation of ethylene signaling, which modulated cortical...
Abstract Background Aberrant activation of the Wnt/β-catenin signaling pathway is one most frequent abnormalities in human cancer, including colorectal cancer (CRC). Previous studies revealed pivotal functions WNT family members as well their prognostic values. Nevertheless, role and mechanisms underlying WNT7b development remains unclear. Methods In this study, expression was measured by immunohistochemical staining 100 cases surgically resected cancerous tissues matched adjacent normal...
Conclusion: SOD1 is an important gene related to noise-induced hearing loss (NIHL), and its effect dependent on noise exposure levels. Objectives: To test whether the polymorphisms in CuZn-superoxide dismutase (SOD1) are associated with susceptibility NIHL Chinese population. Methods: Audiometric data from 2400 Han people exposed occupational were analyzed. DNA samples collected 10% most susceptible resistant individuals. Four SNPs introns of genotyped their effects interactions Results:...
A series of N-sulfonyl-aminobiaryl derivatives have been examined as novel antitubulin agents. Compound 21 [N-(4′-cyano-3′-fluoro-biphenyl-2-yl)-4-methoxy-benzenesulfonamide] exhibits remarkable antiproliferative activity against four cancer cell lines (pancreatic AsPC-1, lung A549, liver Hep3B, and prostate PC-3) with a mean GI50 value 57.5 nM. Additional assays reveal that inhibits not only tubulin polymerization but also the phosphorylation STAT3 inhibition an IC50 0.2 μM. Four additional...
Graphene oxide-based aptamer fluorescent sensors were constructed for the detection of trace zearalenone in wheat and rice wine.
Tight control of lateral root (LR) initiation is vital for system architecture and function. Regulation cortical microtubule reorganization involved in the asymmetric radial expansion founder cells during LR Arabidopsis (Arabidopsis thaliana). However, critical genetic evidence on role microtubules lacking mechanisms underlying this regulation are poorly understood. Here, we found that previously uncharacterized microtubule-stabilizing protein TPX2-LIKE5 (TPXL5) participates initiation,...