A5101571213- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Autoimmune Bullous Skin Diseases
- Atherosclerosis and Cardiovascular Diseases
- Dermatology and Skin Diseases
- Hematopoietic Stem Cell Transplantation
- Diabetes and associated disorders
- Renal Diseases and Glomerulopathies
- Skin Protection and Aging
- Cell Adhesion Molecules Research
- Galectins and Cancer Biology
- Monoclonal and Polyclonal Antibodies Research
- Reproductive tract infections research
- Acne and Rosacea Treatments and Effects
- Immune Cell Function and Interaction
- Platelet Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- IL-33, ST2, and ILC Pathways
- Peroxisome Proliferator-Activated Receptors
- Retinoids in leukemia and cellular processes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Histiocytic Disorders and Treatments
- Dermatologic Treatments and Research
- Optimism, Hope, and Well-being
Southern Medical University
2008-2023
Nanfang Hospital
2008-2023
Southwest Medical University
2022
National Natural Science Foundation of China
2013
Huangshi Central Hospital
2009
Shandong Mental Health Center
1997
Although transdermal preparations of local anesthetics have been used to reduce pain caused by skin surgery, these cannot effectively penetrate through the epidermis because barrier formed stratum corneum and thick epidermis. Ethosomes can transport drugs across their thermodynamic stability, small size, high encapsulation efficiency, percutaneous penetration. We evaluated lidocaine base ethosomes measuring loading penetration capability in vitro, effectiveness cutaneous irritation...
Proteolipid protein 2 (PLP2) has been shown to be upregulated in several cancers, including breast cancer, hepatocellular carcinoma, osteosarcoma, and melanoma. PLP2 specifically binds phosphatidylinositol 3 kinase activate the B pathway enhance cell proliferation, adhesion, invasion melanoma cells. Therefore, we speculated that exhibits oncogenic potential. However, regulatory mechanisms of cancer cells remain unclear. Herein, found microRNA (miR)-664 expression was significantly...
Background Cognitive Dysfunction (CD) can occur in Systemic Lupus Erythematosus (SLE) before the occurrence of Neuropsychiatric (NPSLE). Given reversibility and fluctuation SLE-related CD, research for possible predictors is great significance early detection intervention. Objective We sought to determine prevalence, involved domains, CD SLE patients. Methods conducted a retrospective cross-sectional study at Nanfang Hospital from 2018 2019. A total 78 patients were recruited. The Montreal...
Psoriasis is a chronic, complicated, and recurrent inflammatory skin disease, whose precise molecular mechanisms need to be further explored. The lncRNA bladder cancer-associated transcript 1 (BLACAT1) aberrantly expressed in many cancers associated with cellular hyperproliferation may play role the pathogenesis of psoriasis. Thus, this study aimed at identifying primary mechanism BLACAT1 psoriasis pathogenesis.Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) was...
Pemphigus is an autoimmune disease that causes blisters and erosions in the skin mucous membranes. The development of pemphigus associated with imbalance T‑cell humoral responses. MicroRNAs (miRNAs) can regulate many cell functions. However, whether miRNA expression altered peripheral blood mononuclear cells (PBMCs) during pathogenesis has not been clarified. aim present study was to examine profiles PBMCs from patients pemphigus. miRNAs active (n=3) healthy subjects were analyzed by...
Expression of microRNA-338-3p (miR-338-3p) was aberrantly elevated in pemphigus vulgaris (PV), although its role PV is still unknown. The present study investigated the functional and possible molecular mechanisms miR-338-3p PV. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) performed to detect expression peripheral blood mononuclear cells (PBMCs) from patients with Correlation disease severity anti-desmoglein 3 antibody (anti-Dsg3) titers were analyzed effects...
Abstract Background Pemphigus is a rare and fatal autoimmune disease for which the treatment options are limited. This study aimed to evaluate efficacy of autologous peripheral hematopoietic stem cell transplantation ( APHSCT ) pemphigus. Methods We conducted 12 pemphigus patients (seven males five females, mean age 23.8 years) with life‐threatening complications or who responded poorly conventional therapy. Peripheral blood cells were mobilized cyclophosphamide, granulocyte...
Keratinocyte is a key component of the skin barrier and maintains homeostasis. As an environmental pathogenic factor, PM2.5 can cause epidermal cell damage, but mechanism remains to be elucidated. The present study aimed evaluate effect caused by in HaCaT cells investigate underlying mechanisms.HaCaT were treated with for 12 h or 24 h, either alone combined UVB irradiation. A Cell Counting Kit (CCK-8) assay was carried out detect on viability. Flow cytometry, Western Blot, AO staining...
To examine the serum levels of interleukin (IL)-30 in patients with psoriasis and evaluate correlations Psoriasis Area Severity Index (PASI).Serum was collected from 26 healthy controls a case-control setting, level IL-30 determined using an enzyme-linked immunosorbent assay. Statistical analysis among groups further correlation analyses PASI scores were performed.A significant increase compared observed. In addition, positive between concentration found psoriasis.IL-30 is presumably...
Evidence suggests that peroxisome proliferator activated receptor-γ (PPAR-γ) acts as a tumor suppressor in multiple types of cancer; however, the role action PPAR-γ on human epidermoid carcinoma is unclear. The present study investigated effects agonist, rosiglitazone, cell growth using A431 line. rosiglitazone viability and proliferation were evaluated with MTS [3H] thymidine incorporation assays. cycle apoptosis analyzed by flow cytometry, western blotting. It was identified inhibited...
<br>Langerhans cell histiocytosis (LCH) is a proliferative disease commonly seen in the pediatric population but rarely encountered adult population. The exact etiology remains unclear. It has various clinical features and very likely to be misdiagnosed. Histopathology immunohistochemistry are important for diagnosis of LCH. Treatment protocols remain controversial. Herein, we report rare onset LCH, which confined skin. A 50-year-old Chinese man presented with nodule itchy rashes on left...
Pemphigus is an autoimmune disease of the skin and mucous membranes. Glucocorticoids have been most effective drug for treatment pemphigus; however, some patients are insensitive to glucocorticoid therapy. Cyclophosphamide has extensively used in pemphigus.To observe evaluate efficacy safety high-dose with weekly intravenous cyclophosphamide refractory pemphigus vulgaris glucocorticoids.Clinical data 19 (insensitive glucocorticoid) who were treated glucocorticoids(1.5 mg/kg/day prednisone)...
Objective To detect the expression of Blimpl gene in MRL/lpr mice, so as to provide new ideas for plasma cell-targeting therapy systemic lupus erythematosus （SLE）. Methods Electrophoretic mobility shift assay （EMSA） and chromatin immunoprecipitation analysis （CHIP） were performed evaluate regulatory effect on B cell maturation antigen （BCMA）, fluorescence-based quantitative PCR was carried out Blimp1 mRNA spleen lymph node tissue mice normal control mice. The intergroup difference assessed...