A5088044288- melanin and skin pigmentation
- Cancer and Skin Lesions
- Dermatology and Skin Diseases
- Skin and Cellular Biology Research
- Psoriasis: Treatment and Pathogenesis
- Nonmelanoma Skin Cancer Studies
- Genetic and rare skin diseases.
- Cutaneous lymphoproliferative disorders research
- Connexins and lens biology
- Hedgehog Signaling Pathway Studies
- Retinoids in leukemia and cellular processes
- Toxin Mechanisms and Immunotoxins
- Ear and Head Tumors
- Autoimmune Bullous Skin Diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Dermatological and Skeletal Disorders
- Dermatologic Treatments and Research
- Acne and Rosacea Treatments and Effects
- Caveolin-1 and cellular processes
- Wnt/β-catenin signaling in development and cancer
- Advancements in Transdermal Drug Delivery
- Hippo pathway signaling and YAP/TAZ
- Nail Diseases and Treatments
- Genetic Syndromes and Imprinting
- Vascular Tumors and Angiosarcomas
Southern Medical University
2017-2025
Nanfang Hospital
2015-2025
National Natural Science Foundation of China
2022
Creative Commons
2022
A keloid is a disease of excessive fibrosis that characterized by the aberrant proliferation fibroblasts. However, molecular mechanisms fibroblasts during development keloids remain unclear. This study aims to identify new targets promote and migration fibroblasts, providing ideas for prevention treatment keloids.We utilized bioinformatics tools analyze data from (KFs) available in Gene Expression Omnibus (GEO) database key genes involved development. Homeobox C6 (HOXC6) emerged as hub gene...
Background: Vitiligo is an acquired depigmentation skin disorder mainly caused by the destruction of melanocytes. There are many therapeutic options available for vitiligo, but not uniformly effective.Objectives: This study aimed to explore clinical effect autologous non-cultured epidermal cell suspension (NCES) technique in treatment patients with stable vitiligo.Methods: A retrospective before-after comparisons was undertaken 41 vitiligo who received NCES technique. The percentage...
Abstract Long‐term systemic treatment with acitretin for severe hyperkeratotic disorders is needed to maintain quality of life afflicted patients, but has been limited owing its potential side‐effects including skeletal malformations, particularly children during their growth and development. A retrospective investigation was conducted three a disorder, namely Darier's disease, bullous ichthyosiform erythroderma or lamellar ichthyosis, who were continuously maintained on 0.2–0.3 mg/kg per...
Abstract Background Pemphigus is a rare and fatal autoimmune disease for which the treatment options are limited. This study aimed to evaluate efficacy of autologous peripheral hematopoietic stem cell transplantation ( APHSCT ) pemphigus. Methods We conducted 12 pemphigus patients (seven males five females, mean age 23.8 years) with life‐threatening complications or who responded poorly conventional therapy. Peripheral blood cells were mobilized cyclophosphamide, granulocyte...
Abstract Background Erythrokeratodermia variabilis et progressiva (EKVP, OMIM 133200) is a rare hereditary disorder characterized by varies from transient, fast moving erythema to persistent brown hyperkeratotic plaques. Recently, mutations in the genes gap junction alpha 1 gene (GJA1), GJB3, and GJB4 have been reported cause EKVP. Here, we report identification of two de novo missense GJA1 unrelated individuals with Methods The patients his family members were subjected mutation detection...
To investigate the psychological health and related risk factors in patients suffering from psoriasis. A total of 245 inpatients outpatients with psoriasis were selected January 2014 to December 2015. Patients assessed a homemade questionnaire as well Psoriasis Area Severity Index (PASI), Selfrating Anxiety Scale, Self-rating Depression Trait Coping Style Questionnaire Social Avoidance Distress Scale.Differences sex, age, marital status, type medical payment, occupation, economic situation,...
Circular RNAs (circRNAs) act as sponges of noncoding and have been implicated in many pathophysiological processes, including tumor development progression. However, their roles cutaneous squamous cell carcinoma (cSCC) are not yet well understood. This study aimed to identify differentially expressed circRNAs potential functions carcinogenesis. The expression profiles three paired cSCC adjacent nontumorous tissues were detected with RNA sequencing bioinformatics analysis. candidate validated...
Verrucous epidermal nevus (VEN) is a skin disorder that commonly presents at birth; it characterized by skin-colored to brown verrucous papules in linear distribution following Blaschko's lines. Even though extremely rare, VEN has been associated with malignant transformation. treated different treatment modalities varying and frustrating results. We introduce new type of treatment. The fractional micro-plasma radio-frequency (RF) technology, which uses unipolar RF technology provoke plasma...
Most available options for the treatment of warts are limited by potential scarring, pain, lack response, or recurrences, and patients often unable to tolerate accept those experiences. The aim this study was evaluate clinical efficacy safety oral systemic acitretin monotherapy in with extensive/recalcitrant cutaneous warts. were given a dose 0.8 mg kg-1 day-1 , assessed every 2 weeks months. A total 14 (12 males females) included, an age 14-60 years (mean 33 ± 14.7 years) course 4-48 months...
Human papillomavirus (HPV) infection and related diseases are difficult clinical challenges. The efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating condyloma acuminata is remarkable, with high virus clearance low recurrence rates. Podophyllotoxin (POD) the first-line drug a significant therapeutic effect on acuminata. However, no studies have determined whether POD-combined ALA-PDT improves high-risk (HR)-HPV-infected cell killing. We aimed to investigate could...
Pachyonychia congenita is an uncommon autosomal dominant skin disorder characterized by hypertrophic nail dystrophy, palmoplantar keratoderma, oral leukokeratosis, and cutaneous cysts. And fissured tongue rarely reported in patients with pachyonychia congenita. The disease primarily associated mutations five keratin genes, namely KRT6A, KRT6B, KRT6C, KRT16 or KRT17. Herein we report a 9-year-old Chinese girl who has thickened nails, keratinized plaques, since birth. To investigate the...
Abstract Objectives To investigate the efficacy of Fractional Radiofrequency Microneedling (FRM) in treating corticosteroid‐induced facial erythema. Methods A retrospective study was conducted involving eight patients diagnosed as Each patient underwent a single session FRM. Evaluative measures included Clinician's Erythema Assessment (CEA), Patient's Self‐Assessment (PSA), assessment telangiectasia severity, procedure‐associated pain (10‐point scale), satisfaction (3‐point scale) and...
Hemoporfin-mediated photodynamic therapy (HMME-PDT) has been recognized as a safe and effective treatment for port wine stain (PWS). However, some patients show limited improvement even after multiple treatments. Herein, we aim to explore the effect of autophagy on HMME-PDT in human umbilical vein endothelial cells (HUVECs), so provide theoretical basis strategies enhance clinical effectiveness. Establish vitro system by HUVECs. Apoptosis necrosis were identified Annexin Ⅴ-FITC/PI flow...
Abstract Background Epidermolytic palmoplantar keratoderma (EPPK) is a rare skin disorder and its pathogenesis inheritability are unknown. Objective To investigate the inheritance of EPPK. Methods Two EPPK cases occurred in three‐generation Chinese family. Patient–parents trio was carried out identified candidate variants were confirmed by Sanger sequencing. Results A heterozygous missense pathogenic variant, c.488G > (p.Arg163Gln), keratin ( KRT ) 9 gene detected proband his son via...
<b><i>Objective:</i></b> Investigate the role of Yes-associated protein (YAP1) in development condyloma acuminatum (CA). <b><i>Methods:</i></b> We enrolled 30 male patients with CA and 20 healthy individuals as a control group, to compare YAP1 expression their tissue samples. Following this, we overexpressed downregulated <i>YAP1</i> HaCaT cells examine migratory, proliferative, apoptotic potential expressing different levels YAP1....