A5073529494- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- COVID-19 Impact on Reproduction
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Healthcare and Venom Research
- Adipose Tissue and Metabolism
- Cancer Immunotherapy and Biomarkers
- Traditional Chinese Medicine Studies
- CAR-T cell therapy research
- Marine and coastal ecosystems
- Osteoarthritis Treatment and Mechanisms
- Extracellular vesicles in disease
- Marine Toxins and Detection Methods
- RNA modifications and cancer
- Caveolin-1 and cellular processes
- Cancer Cells and Metastasis
- Infant Nutrition and Health
- Balance, Gait, and Falls Prevention
- Immune Cell Function and Interaction
- Obstructive Sleep Apnea Research
- Microbial Community Ecology and Physiology
- Helicobacter pylori-related gastroenterology studies
- Metastasis and carcinoma case studies
Sichuan Animal Science Academy
2012-2023
Changzhi Medical College
2023
General Hospital of Guangzhou Military Command
2023
Inner Mongolia Medical University
2019
Third Xiangya Hospital
2017-2018
Central South University
2017-2018
Xiamen University
2013
Breast milk is the primary source of nutrition for newborns, and rich in immunological components. MicroRNAs (miRNAs) are present various body fluids selectively packaged inside exosomes, a type membrane vesicles, secreted by most cell types. These exosomal miRNAs could be actively delivered into recipient cells, regulate target gene expression function. Here, we analyzed lactation-related miRNA profiles porcine exosomes across entire lactation period (newborn to 28 days after birth) deep...
Neijiang (NJ) and Yacha (YC) are two indigenous pig breeds in the Sichuan basin of China, displaying higher resistance to diseases, lower lean ratio, slower growth rate than commercial Western breed Yorkshire (YS). The molecular mechanisms underlying differences development between these still unknown. In present study, five pigs from NJ, YC, YS were subjected whole genome resequencing, then differential single-nucleotide polymorphisms (SNPs) screened using a 10-kb window sliding 1-kb step...
Studying the composition and developmental mechanisms in mammary gland is crucial for healthy growth of newborns. The inherently heterogeneous, its physiological function dependents on gene expression multiple cell types. Most studies focused epithelial cells, disregarding role neighboring adipocytes.Here, we constructed largest transcriptomic dataset porcine cells thus far. captured 126,829 high-quality nuclei from glands across five stages (d 90 gestation, G90; d 0 after lactation, L0; 20...
In the present study, a series of experiments were conducted to explore function miR-374b and regulatory relationship among miR-374b, GATA3 SEMA3B in glioma.MiR-374b mimics inhibitors employed regulate expression.Besides, qRT-PCR assay was used for detecting expression level mRNAs.To verify targeting between GATA3, dual luciferase analysis utilized.Moreover, chromatin immunoprecipitation (ChIP) performed identify correlation with SEMA3B.Furthermore, si1-GATA3, si2-GATA3 pc-GATA3 pc-SEMA3B...
Summary Elucidation of the pig micro RNA ome is essential for interpreting functional elements genome and understanding genetic architecture complex traits. Here, we extracted small s from skeletal muscle adipose tissue, compared their expression levels between one Western breed (Yorkshire) seven indigenous Chinese breeds. We detected 172 known porcine (mi s) 181 novel mi s. Differential analysis found 92 12 differentially expressed in tissue respectively. that different breeds shared common...
Gene expression profiles of blood can reflect the physiopathologic status immune system. The dynamic microRNA (miRNA) peripheral from pigs at different developmental stages, and how differential miRNAs might relate to system development, are unknown. In this study, samples taken five stages were used construct 15 miRNA libraries (three biological replicates/stage): 0 days (newborn), 30 (weaning), 60 (weaned), 180 360 (puberty). We identified 295 known mature miRNAs. Hierarchical clustering...
We investigated the temporal expression profiles of long noncoding RNA (lncRNA) and mRNA in peripheral blood pigs during development identified lncRNAs that are related to blood-based immune system.Peripheral samples were obtained from at 0, 7, 28, 180 days 2 years age. sequencing was performed survey lncRNA transcriptomes samples. Short time-series miner (STEM) used show patterns mRNAs lncRNAs. Gene ontology Kyoto encyclopedia genes genomes analyses assess genes' biological relevance. To...
With the gradual increase in diagnosis rate of early gastric cancer, clinicians must consider prevention anatomical structure and physiological function while ensuring radical treatment tumor. Pylorus-preserving gastrectomy is a function- preserving operation that preserves pylorus, inferior pyloric vessel, vagus nerve patients with middle cancer. One major controversies at present thoroughness limited lymph node dissection for pyloric-preserving gastrectomy. Various studies have reported...
To investigate the effect of ARL67156, a small-molecule inhibitor CD39, on cytotoxicity natural killer (NK) cells against gastric cancer cells.