A5100621638- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Virus-based gene therapy research
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Respiratory viral infections research
- Cancer, Lipids, and Metabolism
- Viral Infectious Diseases and Gene Expression in Insects
- Plant Molecular Biology Research
- Genetic and phenotypic traits in livestock
- Air Quality and Health Impacts
- Genetic Mapping and Diversity in Plants and Animals
- Climate Change and Health Impacts
- Extracellular vesicles in disease
- Legume Nitrogen Fixing Symbiosis
- Bacteriophages and microbial interactions
- Metabolism, Diabetes, and Cancer
- Photodynamic Therapy Research Studies
- Eicosanoids and Hypertension Pharmacology
- Animal Virus Infections Studies
- Plant Gene Expression Analysis
- Plant-Microbe Interactions and Immunity
Qilu Hospital of Shandong University
2024
Sichuan Animal Science Academy
2019-2023
Kunming Medical University
2020
First Affiliated Hospital of Zhengzhou University
2020
Shanxi Provincial Cancer Hospital
2019
Southeast University
2018
Wuhan University
2008-2017
Renmin Hospital of Wuhan University
2008-2017
Harbin Medical University
2017
Fourth Affiliated Hospital of Harbin Medical University
2017
Mitogen-activated protein kinase (MAPK) cascades have important functions in plant growth, development, and response to various stresses. The MAPKK MAPKKK gene families tomato never been systematically analyzed. In this study, we performed a genome-wide analysis of the identified 5 genes 89 genes. Phylogenetic analyses showed that all formed four groups (groups A, B, C, D), whereas were classified into three subfamilies, namely, MEKK, RAF, ZIK. Evolutionary whole genome or chromosomal...
Nitrogen (N) is both an important macronutrient and a signal for plant growth development. However, the early regulatory mechanism of plants in response to N starvation not well understood, especially cucumber, economically crop that normally consumes excessive during production. In this study, time-course transcriptome cucumber leaves under deficiency was monitored using RNA sequencing (RNA-Seq). More than 23,000 transcripts were examined leaves, which 364 genes differentially expressed...
The present study investigated the mechanism underlying Toll-like receptor 4 (TLR4)-mediated stimulation of hypoxia-inducible factor-1α (HIF-1α) activity and its association with reactive oxygen species (ROS) in cervical cancer cells. SiHa cells were cultured randomized to control, lipopolysaccharide (LPS), methyl-β-cyclodextrin (MβCD)+LPS, ammonium pyrrolidinedithiocarbamate (PDTC)+LPS, ST2825+LPS small interfering (si) RNA TLR4+LPS treatment groups. Cell proliferation was quantified using...
Long non-coding RNAs (lncRNAs) may be a regulatory factor of tumorigenesis. However, it is unclear what its biomechanisms are in breast cancer. In this study, different lncRNAs were detected cancer through microarray analysis (GSE119233) and LINC01705 was selected for further study. qRT-PCR then utilized the detection expression cells. A transwell assay, flow cytometry, 5-ethynyl-2'-deoxyuridine (EdU), cell counting Kit-8 (CCK-8), wound-healing assay performed to determine migration,...
Neijiang (NJ) and Yacha (YC) are two indigenous pig breeds in the Sichuan basin of China, displaying higher resistance to diseases, lower lean ratio, slower growth rate than commercial Western breed Yorkshire (YS). The molecular mechanisms underlying differences development between these still unknown. In present study, five pigs from NJ, YC, YS were subjected whole genome resequencing, then differential single-nucleotide polymorphisms (SNPs) screened using a 10-kb window sliding 1-kb step...
Thyroid-carcinoma (THCA) is the most common malignancy with an increasing incidence. Recent evidence has emphasized role of microRNA (miRNA) in THCA. However, knowledge concerning roles miRNAs THCA still limited. We therefore use a miRNA-target gene differential regulatory network (MGDRN) to identify key and characterize their synergistic regulation Both interactions from multiple databases negative expression correlations between genes were used interactions. Then, two networks involving...
Gene expression profiles of blood can reflect the physiopathologic status immune system. The dynamic microRNA (miRNA) peripheral from pigs at different developmental stages, and how differential miRNAs might relate to system development, are unknown. In this study, samples taken five stages were used construct 15 miRNA libraries (three biological replicates/stage): 0 days (newborn), 30 (weaning), 60 (weaned), 180 360 (puberty). We identified 295 known mature miRNAs. Hierarchical clustering...
We investigated the temporal expression profiles of long noncoding RNA (lncRNA) and mRNA in peripheral blood pigs during development identified lncRNAs that are related to blood-based immune system.Peripheral samples were obtained from at 0, 7, 28, 180 days 2 years age. sequencing was performed survey lncRNA transcriptomes samples. Short time-series miner (STEM) used show patterns mRNAs lncRNAs. Gene ontology Kyoto encyclopedia genes genomes analyses assess genes' biological relevance. To...
Objective To examine the impact of metabolic syndrome (MS) on clinicopathological characteristics and prognosis patients with colorectal cancer (CRC). Methods The clinical data 650 CRC admitted in Shanxi Provincial Cancer Hospital between January 2010 December 2011 were retrospectively analyzed. Among there 190 cases complicated MS (MS group) 460 without (non-MS group), features compared two groups. Results The serum insulin insulin-like growth factor-1 (IGF-1) levels group...
Abstract Background: Serum alpha-fetoprotein (AFP) is the most widely used serological marker to diagnose hepatocellular carcinoma (HCC). High expression of AFP significantly associated with early postoperative recurrence and poor prognosis. However, upstream regulation mechanism not fully understood, role long-chain non-coding RNA (lncRNA) in has been reported. Methods: HCC cases from The Cancer Genome Atlas (TCGA) database were divided into 3 groups: (1) AFP<10ng/ml, (2)...