A5102969349- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Genetic and phenotypic traits in livestock
- Viral gastroenteritis research and epidemiology
- Meat and Animal Product Quality
- Innovations in Educational Methods
- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- Biomedical Text Mining and Ontologies
- RNA Interference and Gene Delivery
- Animal Disease Management and Epidemiology
- Plant Disease Management Techniques
- Machine Learning in Bioinformatics
- Mycotoxins in Agriculture and Food
- Immune Response and Inflammation
- Higher Education Research Studies
- Circular RNAs in diseases
- Nematode management and characterization studies
- Microbial infections and disease research
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Immunotherapy and Immune Responses
East China Normal University
2024
Sichuan Animal Science Academy
2009-2021
Growth performance and meat quality are important traits for the pig industry consumers. Adipose tissue is main site at which fat storage fatty acid synthesis occur. Therefore, we combined high-throughput transcriptomic sequencing in adipose muscle tissues with quantification of corresponding phenotypic features using seven Chinese indigenous breeds one Western commercial breed (Yorkshire). We obtained data on 101 traits, from principal component analysis distinguished two groups: associated...
Summary Elucidation of the pig micro RNA ome is essential for interpreting functional elements genome and understanding genetic architecture complex traits. Here, we extracted small s from skeletal muscle adipose tissue, compared their expression levels between one Western breed (Yorkshire) seven indigenous Chinese breeds. We detected 172 known porcine (mi s) 181 novel mi s. Differential analysis found 92 12 differentially expressed in tissue respectively. that different breeds shared common...
Transforming growth factor beta 1 (TGF-β1) was of importance in the pathogenesis porcine reproductive and respiratory syndrome virus (PRRSV). To determine whether knockdown TGF-β1 gene expression could facilitate control PRRSV infection, specific sequences for expressing shRNA targeted to were synthesized cloned into pSilencer 3.1-H1 neovector. Then they used transfect peripheral blood mononuclear cells Tibetan pig (Tp-PBMCs) followed by inoculation. The positive recombinant plasmids...
Education and human capital drive economic societal development, necessitating increased inputs, outputs, efficiency to improve resource allocation. Using principal component analysis, spatial correlation, fixed-effect data envelopment analysis models, we evaluate higher education inputs outputs. We find that financial investment drives transformation. Furthermore, the input output of China's are stronger in east, central western regions show a catch-up effect; scaling alone does not...
In order to develop cost-effective immunomodulator, the recombinant Pichia pastoris were firstly constructed co-express porcine IL-2/4/6 genes, and then fermented feed 45-days Tibetan piglets at different doses evaluate its effects on immunity of PRRS vaccination, which simultaneously received intramuscular injection inactivated vaccine. The results found that leukocytes, IgG specific antibody PRRSV, Th Tc cells increased significantly in blood treated comparison with those control (P <...
Gene expression profiles of blood can reflect the physiopathologic status immune system. The dynamic microRNA (miRNA) peripheral from pigs at different developmental stages, and how differential miRNAs might relate to system development, are unknown. In this study, samples taken five stages were used construct 15 miRNA libraries (three biological replicates/stage): 0 days (newborn), 30 (weaning), 60 (weaned), 180 360 (puberty). We identified 295 known mature miRNAs. Hierarchical clustering...
Summary lncRNAs play crucial roles in fat metabolism animals. Previously, we have compared the mRNA transcriptome profiles between seven fat‐type Chinese pig breeds and one lean‐type Western breed (Yorkshire, YY). The associations differentially expressed (DE) genes phenotypical traits were investigated. In present study, to further explore underlying regulatory mechanisms, sequenced YY indigenous breeds. results showed 9114 7538 DE at least adipose muscle tissue respectively. KEGG...