A5075188178- Electrospun Nanofibers in Biomedical Applications
- Lysosomal Storage Disorders Research
- Digital Mental Health Interventions
- Acute Myeloid Leukemia Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Treatment and Pharmacology
- Mental Health via Writing
- Reproductive tract infections research
- Cervical Cancer and HPV Research
- Tissue Engineering and Regenerative Medicine
- Trypanosoma species research and implications
- Zebrafish Biomedical Research Applications
- Myasthenia Gravis and Thymoma
- Pericarditis and Cardiac Tamponade
- Congenital heart defects research
- Mental Health Treatment and Access
Reutlingen University
2023
Leiden University Medical Center
2019-2022
Significance Anthracyclines like doxorubicin are anticancer drugs, used by over 1 million cancer patients annually. However, they cause severe side effects, most notably, cardiotoxicity and therapy-related malignancies. It is unclear whether these effects directly linked to their activity. Doxorubicin exerts two activities: DNA damage chromatin damage. Here, we show that both activities conspire in the cardiotoxicity, while variants with only chromatin-damaging activity remain active drugs...
In this paper, we present a novel artificial intelligence (AI) application for depression detection, using advanced transformer networks to analyse clinical interviews. By incorporating simulated data enhance traditional datasets, overcome limitations in protection and privacy, consequently improving the model's performance. Our methodology employs BERT-based models, GPT-3.5, ChatGPT-4, demonstrating state-of-the-art results detecting from linguistic patterns contextual information that...
In Gaucher disease (GD), the deficiency of glucocerebrosidase causes lysosomal accumulation glucosylceramide (GlcCer), which is partly converted by acid ceramidase to glucosylsphingosine (GlcSph) in lysosome. Chronically elevated blood and tissue GlcSph thought contribute symptoms GD patients as well increased risk for Parkinson's disease. On other hand, formation may be beneficial since water soluble sphingoid base excreted via urine bile. To study role excessive during deficiency, we...
Cardiovascular diseases caused by loss of functional cardiomyocytes (CMs) are a major cause mortality and morbidity worldwide due in part to the low regenerative capacity adult human heart. Human pluripotent stem cell (hPSC)-derived cardiovascular progenitor cells (CPCs) potential source for cardiac repair. The aim this study was examine impact extensive remuscularization coincident revascularization on remodelling function mouse model myocardial infarction (MI) transplanting doxycycline...