A5017817301- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Advancements in Battery Materials
- RNA modifications and cancer
- Advanced Battery Materials and Technologies
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Anorectal Disease Treatments and Outcomes
- Pelvic floor disorders treatments
- Epigenetics and DNA Methylation
- Semiconductor materials and devices
- Supercapacitor Materials and Fabrication
- Cancer-related molecular mechanisms research
- Bladder and Urothelial Cancer Treatments
- Luminescence and Fluorescent Materials
- Fluid Dynamics Simulations and Interactions
- Graphene research and applications
- Immune Response and Inflammation
- Single-cell and spatial transcriptomics
- Chromosomal and Genetic Variations
- Genetic factors in colorectal cancer
- Advanced battery technologies research
- Advanced Battery Technologies Research
- Immune Cell Function and Interaction
Xiamen University
2023-2024
Cardiff West Community High School
2024
Peking University
2022-2024
Center for Life Sciences
2024
Collaborative Innovation Center of Chemistry for Energy Materials
2023-2024
South China University of Technology
2019-2024
China University of Geosciences
2024
First Affiliated Hospital of Zhengzhou University
2023-2024
Nanjing Normal University
2022-2024
Wuhan University of Technology
2021-2023
Layered double-hydroxide (LDH) has been considered an important class of electrocatalysts for the oxygen evolution reaction (OER), but adsorption-desorption behaviors intermediates on its surface still remain unsatisfactory. Apart from transition-metal doping to solve this electrocatalytic problem LDH, rare-earth (RE) species have sprung up as emerging dopants owing their unique 4f valence-electronic configurations. Herein, Er is chosen a RE model improve OER activity LDH via constructing...
In this study, we comprehensively charted the cellular landscape of colorectal cancer (CRC) and well-matched liver metastatic CRC using single-cell spatial transcriptome RNA sequencing. We generated 41,892 CD45 − nonimmune cells 196,473 + immune from 27 samples six patients, found that CD8_CXCL13 CD4_CXCL13 subsets increased significantly in exhibited high proliferation ability tumor-activating characterization, contributing to better prognosis patients. Distinct fibroblast profiles were...
The working mechanism of LiCoO2 beyond 4.6 V presents complicated issues: (1) the ambiguous multistructural evolutions, (2) vague O-related anionic redox reactions (ARR) triggered by overlap Co–O bands, and (3) serious electrode–electrolyte interface stability challenges. intricate relationship among them turns into a classic "chicken egg" conundrum, leading to confusing evolution process LiCoO2. Herein, from an ingenious perspective combining stacking faults nonhomogeneous delithiation, we...
Abstract Exploring an efficient nonnoble metal catalyst for hydrogen evolution reaction (HER) is critical industrial alkaline water electrolysis. However, it remains a great challenge due to the additional energy required H─OH bond cleavage and lack of enough H 2 O adsorption sites most catalysts. Herein, integration oxophilic Eu 3 with NiCo alloy evoked multisite synergism facilitate dissociation HER proposed. The optimized ‐NiCo exhibits excellent activity low overpotential only 60 mV at...
This study aimed to develop an efficient step-by-step osteosarcoma (OS)-targeting liposome system functionalized with a redox-cleavable, bone- and cluster of differentiation 44 (CD44)-dual-targeting polymer. Furthermore, the effect coadministration tumor-penetrating peptide, internalizing RGD (iRGD), was investigated. First, bone-targeting moiety, alendronate (ALN), conjugated hyaluronic acid (HA), ligand for CD44. ALN–HA conjugate coupled DSPE–PEG2000–COOH through bioreducible disulfide...
Lung cancer, one of the most common malignant tumors, exhibits high inter- and intra-tumor heterogeneity which contributes significantly to treatment resistance failure. Single-cell RNA sequencing (scRNA-seq) has been widely used dissect cellular composition characterize molecular properties cancer cells their tumor microenvironment in lung cancer. However, transcriptomic among various non-small cell (NSCLC) warrants further illustration.To comprehensively analyze NSCLC, we performed...
Abstract Raising the charging cut‐off voltage of layered oxide cathodes can improve their energy density. However, it inevitably introduces instabilities regarding both bulk structure and surface/interface. Herein, exploiting unique characteristics high‐valence Nb 5+ element, a synchronous surface‐to‐bulk‐modified LiCoO 2 featuring Li 3 NbO 4 surface coating layer, Nb‐doped bulk, desired concentration gradient architecture through one‐step calcination is achieved. Such multifunctional...
Drugs can treat different diseases but also bring side effects. Undetected and unaccepted effects for approved drugs greatly harm the human body huge risks pharmaceutical companies. Traditional experimental methods used to determine have several drawbacks, such as low efficiency high cost. One alternative achieve this purpose is design computational methods. Previous studies modeled a binary classification problem by pairing effects; however, their classifiers only extract one feature from...
With the exponentially increasing requirement for cost-effective energy storage systems, secondary rechargeable batteries have become a major topic of research interest and achieved remarkable progresses. For past few years, growing number studies introduced catalysts or concept catalysis into battery systems achieving better electrochemical performance designing materials with distinctive structures excellent properties. In this brief Perspective, we explore in batteries, including: 1)...
Efforts to improve the specific capacity and energy density of lithium nickel-cobalt-manganese oxide (NCM) cathodes focus on operating at high voltages or increasing nickel content. However, both approaches necessitate a...
Bladder cancer (BCa) is the predominant malignancy of urinary system. Herein, a comprehensive urine proteomic feature was initially established for noninvasive diagnosis and recurrence monitoring bladder cancer. 279 cases (63 primary BCa, 87 nontumor controls (NT), 73 relapsed BCa (BCR), 56 nonrelapsed (BCNR)) were collected to screen protein biomarkers. 4761 3668 proteins qualified quantified by DDA sequential window acquisition all theoretical mass spectra (SWATH-MS) analysis in two...
Abstract The investigation of the synthesis and unique photophysical properties two terpyridylplatinum( II ) acetylide complexes [Pt(terpy)(C≡CC 6 H 4 ‐4‐R)] where terpy is 2,2′:6′,2′′‐terpyridyl R = N(CH 3 2 ( 1 or N ‐15‐monoazacrown‐5 has been carried out. These exhibit an absorption band in region 460−650 nm neutral basic solution that corresponds to a ligand‐to‐ligand charge transfer (LLCT) transition from amino‐substituted terpyridyl acceptor. In acidic solutions show lowest‐energy at...
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Extending the depth-of-charge (DoC) of layered oxide cathode presents an essential route to improve competitiveness Na-ion battery versus commercialized LiFePO
Abstract The Notch signalling pathway is involved in the development of several cancers, including colorectal cancer (CRC). However, whether mutations this could alter CRC immunophenotype remains unknown. Here, we investigated relationship between and tumour immune microenvironment by analysing gene expression data from GSE108989 single T cell RNA sequencing set Cancer Genome Atlas (TCGA) set. We found that were associated with an increased number tumour‐specific CD8 + cells decreased...
Purpose: Consensus molecular subtypes (CMS) are mainly used for biological interpretability and clinical stratification of colorectal cancer (CRC) in primary tumors (PT) but few metastases.The heterogeneity CMS distribution metastases the concordance between PT still lack sufficient study.We to classify CRC combine it with histopathological analysis explore differences distant metastases.Patients Methods: We obtained gene expression profiles 942 samples from TCGA database (n=376) GEO...
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Despite advancements in therapeutic methodologies, it still causes a high rate patient mortality. CD8+ tissue-resident memory T (TRM) cells are strategically positioned to mediate effective anti-tumor responses. However, characteristic surface molecules and functions TRM exhibit significant heterogeneity. The roles biological different subsets CRC were determined by clinical samples, bioinformatics analysis, vitro...