A5049934979- Advanced Polymer Synthesis and Characterization
- Supramolecular Self-Assembly in Materials
- Force Microscopy Techniques and Applications
- Polymer Surface Interaction Studies
- Lipid Membrane Structure and Behavior
- Pickering emulsions and particle stabilization
- Spectroscopy and Quantum Chemical Studies
- Surfactants and Colloidal Systems
- biodegradable polymer synthesis and properties
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Advanced Materials and Mechanics
- Material Dynamics and Properties
- RNA Research and Splicing
- Organometallic Complex Synthesis and Catalysis
- Traumatic Brain Injury and Neurovascular Disturbances
- Electrospun Nanofibers in Biomedical Applications
- Hemoglobin structure and function
- Machine Learning in Materials Science
- Spectroscopy Techniques in Biomedical and Chemical Research
- Mineralogy and Gemology Studies
- Lignin and Wood Chemistry
- 3D Printing in Biomedical Research
- Supramolecular Chemistry and Complexes
- Electrochemical Analysis and Applications
- Polymer crystallization and properties
University of Washington
2023-2025
Massachusetts Institute of Technology
2020-2023
Carnegie Mellon University
2014
Abstract Biological fluids, the most complex blends, have compositions that constantly vary and cannot be molecularly defined 1 . Despite these uncertainties, proteins fluctuate, fold, function evolve as programmed 2–4 We propose in addition to known monomeric sequence requirements, protein sequences encode multi-pair interactions at segmental level navigate random encounters 5,6 ; synthetic heteropolymers capable of emulating such can replicate how behave biological fluids individually...
Iron complexes of tetra-amido macrocyclic ligands are important members the suite oxidation catalysts known as TAML activators. activators to be fast homogeneous water (WO) catalysts, producing oxygen in presence chemical oxidants, e.g., ceric ammonium nitrate. These systems exhibited low turnover numbers (TONs). Here we demonstrate immobilization on glassy carbon and paper an ink composed prototype activator, black, Nafion subsequent use this composition heterogeneous electrocatalytic WO....
Abstract 4D printing is the 3D of objects that change chemically or physically in response to an external stimulus over time. Photothermally responsive shape memory materials are attractive for their ability undergo remote activation. While photothermal methods using gold nanorods (AuNRs) used recovery, patterning these into with complex geometries degradable not addressed. Here, fabrication printed bioplastics photo‐activated recovery reported. Protein‐based nanocomposites based on bovine...
Random heteropolymers (RHPs) are an interesting class of materials useful in many theories and applications. While previous studies typically focused on simplified RHP systems, here we explore a more complex scenario inspired by highly heterogeneous molecules like proteins. Our system consists four monomers mimicking different classes amino acids. Using molecular dynamics simulations small-angle X-ray scattering, dynamical structural features these RHPs solution. results show that the...
Protein-based materials can be engineered to derive utility from the structures and functions of incorporated proteins. Modern methods protein engineering bring promise unprecedented control over molecular network design, which will enable new improved functionalities in that incorporate proteins as functional building blocks. For these advantages fully realized, there is a need for robust producing protein-based networks, well tuning their mechanical properties. Light-based 3D-printing...
Synthetic random heteropolymers (RHPs) with high chemical heterogeneity can self-assemble into single-chain nanoparticles that exhibit features reminiscent of natural proteins, such as conformational polymorphism. Using all-atom molecular dynamics simulations, this work investigates the structure and mechanical unfolding a library four-component RHPs in water, studying effects sequence, composition, configuration, weight. Results show compactified have highly dynamic behaviors, which are...
Mechanical deformation of polymer networks causes molecular-level motion and bond scission that ultimately lead to material failure. Mitigating this strain-induced loss in mechanical integrity is a significant challenge, especially the development active shape-memory materials. We report additive manufacturing metamaterials made with protein-based undergo unique stiffening strengthening behavior after shape recovery cycles. utilize bovine serum albumin-based show cyclic tension experiments...
The solution-state fluxional behavior of bullvalene has fascinated physical organic and supramolecular chemists alike. Little effort, however, been put into investigating applications in bulk, partially due to difficulties characterizing such dynamic systems. To address this knowledge gap, we herein probe whether Hardy-Cope rearrangements can be mechanically perturbed bulk polymer networks. We use mechanical analysis demonstrate that the activation barrier glass transition process is...
The interfacial behavior of macromolecules dictates their intermolecular interactions, which can impact the processing and application polymers for pharmaceutical synthetic use. Using molecular dynamics simulations, we observe evolution a random heteropolymer in presence liquid-liquid interfaces. system interest forms single-chain nanoparticles through hydrophobic collapse water, lacking permanent crosslinks making morphology mutable new environments. Complex amphiphilic are shown to be...
This work demonstrates the remodeling of single-chain nanoparticles (SCNPs) upon a transition to organic solvent through molecular dynamics simulations. Methacrylate-based random heteropolymers (RHPs), assembled via transient noncovalent linkages in water, have shown promise an assortment applications that harness their bio-inspired properties. While behavior has been broadly characterized aqueous environments, many newer include use rather than bio-mimetic conditions. The polymer...
Abstract Globally, traumatic injury is a leading cause of suffering and death. The ability to curtail damage ensure survival after major requires time‐sensitive response balancing organ perfusion, blood loss, portability, underscoring the need for novel therapies prehospital environment. Currently, there are few options available control resuscitation (DCR) trauma victims. We hypothesize that synthetic polymers, which tunable, portable, stable under austere conditions, can be developed as...
Globally, traumatic injury is a leading cause of suffering and death. The ability to curtail damage ensure survival after major requires time-sensitive response balancing organ perfusion, blood loss, portability, underscoring the need for novel therapies prehospital environment. Currently, there are few options available control resuscitation (DCR) trauma victims. We hypothesize that synthetic polymers, which tunable, portable, stable under austere conditions, can be developed as effective...
Random heteropolymers (RHPs) are an interesting class of materials useful in many theories and applications. While previous studies typically focused on simplified RHP systems, here we explore a more complex scenario inspired by highly heterogeneous molecules like proteins. Our system consists four monomers mimicking different classes amino acids. Using Molecular Dynamics simulations Small-Angle X-Ray Scattering, dynamical structural features these RHPs solution. results show the assemble...
Interfacial behavior of macromolecules dictates their intermolecular interactions, which can impact processing and application polymers for pharmaceutical synthetic use. Using molecular dynamics simulations, we observe the evolution a random heteropolymer in presence liquid-liquid interfaces. The system interest forms single-chain nanoparticles through hydrophobic collapse water, lacking permanent crosslinks making morphology mutable new environments. complex amphiphilic are shown capable...
The nano-scale dynamics of lipid nanoparticles (LNPs) for drug delivery play a large role in their function. Limited molecular motion is important avoiding degradation prior to entering cells. Intracellularly, enhanced then vital effective endosomal escape. We experimentally quantify such through time-resolved small-angle neutron scattering (TR-SANS). This technique, previously leveraged only simpler self-assembled systems, provides unprecedented insight behavior LNPs. find using TR-SANS...
The nano-scale dynamics of lipid nanoparticles (LNPs) for drug delivery play a large role in their function. Limited molecular motion is important avoiding degradation prior to entering cells. Intracellularly, enhanced then vital effective endosomal escape. We experimentally quantify such through time-resolved small-angle neutron scattering (TR-SANS). This technique, previously leveraged only simpler self-assembled systems, provides unprecedented insight behavior LNPs. find using TR-SANS...
Random heteropolymers (RHPs) are an interesting class of materials useful in many theories and applications. While previous studies typically focused on simplified RHP systems, here we explore a more complex scenario inspired by highly heterogeneous molecules like proteins. Our system consists four monomers mimicking different classes amino acids. Using Molecular Dynamics simulations Small-Angle X-Ray Scattering, dynamical structural features these RHPs solution. results show the assemble...
Synthetic random heteropolymers (RHPs) with high chemical heterogeneity can self-assemble into single-chain nanoparticles that exhibit features reminiscent of natural proteins, such as topological polymorphism. Using all-atom molecular dynamics simulations, this work investigates the structure and mechanical unfolding a library four-component RHPs in water, studying effects sequence, composition, configuration, weight. Results show compactified have highly dynamic behaviors which are...