A5087923553- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemoglobin structure and function
- Hemostasis and retained surgical items
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Traumatic Brain Injury and Neurovascular Disturbances
- Blood properties and coagulation
- Disaster Response and Management
- Dendrimers and Hyperbranched Polymers
- Nanofabrication and Lithography Techniques
- Sepsis Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Supramolecular Self-Assembly in Materials
- Blood transfusion and management
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced biosensing and bioanalysis techniques
- Cardiac Arrest and Resuscitation
University of Washington
2020-2025
Seattle University
2020
Selective therapeutic targeting of T-cell malignancies is difficult due to the shared lineage between healthy and malignant T cells. Current front-line chemotherapy for these cancers largely nonspecific, resulting in frequent cases relapsed/refractory disease. The development approaches effectively treating leukemia lymphoma thus remains a critical goal oncology field. Here, we report discovery DNA aptamer, named HR7A1, that displays low nanomolar affinity integrin α4β1 (VLA-4), marker...
CAR T cell therapies often lack specificity, leading to issues ranging from inadequate antigen targeting off-tumor toxicities. To counter that of we expanded tumor capabilities with universal and spatially defined engagement targets through a combination synthetic biology biomaterial approaches. We developed novel framework, called "In situ Mobilization: Polymer Activated Cell Therapies" (IMPACT) for polymer-mediated, anatomical control IF-THEN gated cells. With IMPACT, regulated payload...
Critical illness leads to rapid fibrinogen consumption, hyperfibrinolysis, and coagulopathy that exacerbates bleeding increases mortality. Immune cell activation inflammation are associated with after injury but play an undetermined role. We performed high dimensional immunophenotyping single-cell imaging flow cytometry investigate for a pathophysiological mechanism governing the effects of leukocyte-associated on function. Fibrinogen was oxidized early, followed by its degradation 3 hours...
There is a lack of prehospital hemostatic agents, especially for noncompressible hemorrhage. We previously reported PolySTAT, unimeric, injectable agent, that physically cross-links fibrin to strengthen clots. In this work, we sought improve the water-solubility and synthesis yield PolySTAT increase likelihood clinical translation, reduce cost, facilitate future mass production. First, focused on side-chain engineering carrier polymer backbone water-solubility. found substitution...
Integration of a peptide modified with self-assembling hydrogels imparts bioactivity to provide potential platform for cell therapy applications.
Abstract Globally, traumatic injury is a leading cause of suffering and death. The ability to curtail damage ensure survival after major requires time‐sensitive response balancing organ perfusion, blood loss, portability, underscoring the need for novel therapies prehospital environment. Currently, there are few options available control resuscitation (DCR) trauma victims. We hypothesize that synthetic polymers, which tunable, portable, stable under austere conditions, can be developed as...
Globally, traumatic injury is a leading cause of suffering and death. The ability to curtail damage ensure survival after major requires time-sensitive response balancing organ perfusion, blood loss, portability, underscoring the need for novel therapies prehospital environment. Currently, there are few options available control resuscitation (DCR) trauma victims. We hypothesize that synthetic polymers, which tunable, portable, stable under austere conditions, can be developed as effective...