A5100344565- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- CAR-T cell therapy research
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Cardiac Ischemia and Reperfusion
- Immunotherapy and Immune Responses
- Acute Kidney Injury Research
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Heat shock proteins research
- Renal function and acid-base balance
- Circular RNAs in diseases
- Colorectal and Anal Carcinomas
- Melanoma and MAPK Pathways
- Cardiac Imaging and Diagnostics
- RNA Research and Splicing
- Pomegranate: compositions and health benefits
- Sepsis Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Acupuncture Treatment Research Studies
- Macrophage Migration Inhibitory Factor
- Chemotherapy-induced cardiotoxicity and mitigation
- Ferroptosis and cancer prognosis
Xuzhou No.1 People's Hospital
2024
Xuzhou Medical College
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Hangzhou Medical College
2024
Zhejiang Provincial People's Hospital
2024
Tongde Hospital of Zhejiang Province
2022-2024
Peking Union Medical College Hospital
2022-2024
Chinese PLA General Hospital
2024
Fujian Provincial Hospital
2019-2024
Nanjing Drum Tower Hospital
2023
Metastasis of colorectal cancer (CRC) depends critically on MMP-9. KiSS-1 is a human malignant melanoma metastasis-suppressor gene. Thus, the interaction between MMP-9 and has drawn considerable attention in recent years. In present study, it was hypothesized that gene could repress metastatic potential cells by inhibiting expression Stable transfection specific siRNA vector CRC cell line HCT-116 achieved lentivirus infection. Moreover, proliferation, invasiveness, apoptosis were evaluated...
Loss of epigenetic gene regulation through altered long noncoding RNA (lncRNA) expression seems important in human cancer. LncRNAs have diagnostic and therapeutic potential, offer insights into the biology disease, but little is known their urothelial Here, we identify differentially expressed lncRNAs with potential regulatory functions cancer.The 17,112 22,074 mRNAs was determined using microarrays 83 normal malignant (discovery) samples selected RNAs qPCR 138 for validation. Significantly...
Increasing evidence demonstrates that long noncoding RNAs (lncRNAs) play important roles in the progression of hepatocellular carcinoma (HCC) by regulating gene expression. However, identification functional lncRNAs HCC remains insufficient. Our study aimed to investigate function lncRNA OGFRP1, which has not been functionally researched before, Hep3B and HepG2 cells.lncRNA OGFRP1 cells was down-regulated using RNAi technology. Quantitative real-time polymerase chain reaction used determine...
Punicalagin (PUN), a major bioactive component in pomegranate juice, has been proven to exert neuroprotective effects against cerebral ischemia/reperfusion (I/R) insult via anti-oxidant properties. This study aims investigate whether PUN provides cardioprotection myocardial I/R (MI/R) injury and the underlying mechanisms. (30[Formula: see text]mg/kg/d) or vehicle was intragastrically administered Sprague-Dawley rats for one week before operation. MI/R induced by ligating left anterior...
The rechallenge of immune checkpoint inhibitors (ICI) is now an optional strategy for patients who discontinued ICI due to immune-related adverse events (irAEs) or disease progression. However, little data available the prognosis and prognostic factors receiving treatment in advanced lung cancer patients. Our study aimed explore efficacy, safety received anti-programmed cell death-1/programmed death ligand 1 (anti-PD-1/PD-L1) inhibitor rechallenge.In our retrospective cohort study,...
BACKGROUND: Quantitative flow ratio (QFR)-based virtual percutaneous coronary intervention (PCI) is associated with improved post-PCI physiological results. Murray law-based QFR (μQFR) a new method for assessment that has higher feasibility and efficiency. The purpose of this study was to investigate the performance μQFR-guided PCI in improving outcomes. METHODS: QUITE RIGHT (Quantitative Flow Ratio Virtual Stenting Angiography Guided Percutaneous Coronary Intervention) prospective,...
Background Non-responsiveness is a major barrier in current cancer immune checkpoint blockade therapies, and the mechanism has not been elucidated yet. Therefore, it necessary to discover biomarkers of tumor immunotherapeutic resistance.
Objective: The occurrence of intramyocardial hemorrhage (IMH) and microvascular obstruction (MVO) in myocardial infarction (MI), known as severe ischemia/reperfusion injury (IRI), has been associated with adverse remodeling.APT102, a soluble human recombinant ecto-nucleoside triphosphate diphosphohydrolase-1, can hydrolyze extracellular nucleotides to attenuate their prothrombotic proinflammatory effects.The purpose this study was temporally evaluate the therapeutic effect APT102 on IRI rats...
In recent years, immunotherapy has become a major research focus in the field of cancer treatment. Because its good efficacy and lasting immune response, checkpoint inhibitors have benefited long-term survival many types patients. However, overactivation system may attack normal organs cause series related adverse reactions. Among them, due to high incidence immune-related colitis, it deserves special attention. Camrelizumab is programmed cell death 1 (PD-1) inhibitor that was developed by...
Abstract Background Non‐small‐cell lung cancer (NSCLC) often presents at later stages, typically associated with poor prognosis. Autophagy genes play a role in the progression of tumors. This study investigated clinical relevance, prognostic value, and biological significance RBBP4 NSCLC. Methods We assessed expression using GSE30219 TCGA NSCLC datasets cells, exploring its links outcomes, tumor immunity, autophagy through bioinformatics analysis after transcriptome sequencing...
Background: Pharmacoeconomic information for pembrolizumab as a second-line lung cancer treatment is insufficient in China, so we aimed to assess its cost-effectiveness versus docetaxel patients with non-small cell (NSCLC) China.
Along with the widespread use of immune checkpoint inhibitors (ICIs), there has been a surge in immune-related adverse events which can limit efficacy ICIs. However, to date, is paucity reports on renal (RAEs) related Therefore, this study incidence, risk factors, pathological features RAEs patients receiving ICI therapy and its association overall survival.The medical records who received at least 1 cycle anti-programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) monoclonal antibody...
Prostate cancer (PCa) is the second most common malignancy affecting men globally. Recent advances in metabolomics have highlighted significant alterations specific amino acid (AA) metabolism linked to PCa, indicating their potential utility diagnosis and therapy. However, no direct causal association between serum AA levels PCa risk has been established. A total of 35 patients with 30 individuals benign prostatic hyperplasia (BPH) were recruited for this study. Targeted metabolomic analysis...
Aim: To investigate the relationship between urinary pH (UpH) and clinical outcome in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention. Methods: Data of 2081 were analyzed, including UpH. Patients divided into UpH <6.0, 6.0≤ <7.0 ≥7.0 based on level. The primary was in-hospital all-cause mortality major adverse events. Results: incidence outcomes significantly higher low group. Multivariate analysis found (<6.0) an independent predictor...
Objective The present study aimed to optimize the established predictive models (REACH-B scoring model) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Methods The surface antigen (HBsAg) positive (> 6 months) patients who were firstly admitted in Liver Center of First Affiliated Hospital, Fujian Medical University between Oct 1st 2004 and May 2014 selected as subjects divided into two groups, namely, case group (HCC group) control (non-HCC group). Clinical data...