A5064176924- Legionella and Acanthamoeba research
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Heme Oxygenase-1 and Carbon Monoxide
- Vibrio bacteria research studies
- Escherichia coli research studies
- Biomedical Research and Pathophysiology
- Salmonella and Campylobacter epidemiology
- Mitochondrial Function and Pathology
- Cancer Research and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Jilin University
2019-2024
First Hospital of Jilin University
2023-2024
Many bacterial pathogens have evolved effective strategies to interfere with the ubiquitination network evade clearance by innate immune system. Here, we report that OTUB1, one of most abundant deubiquitinases (DUBs) in mammalian cells, is subjected both canonical and noncanonical during Legionella pneumophila infection. The effectors SidC SdcA catalyze OTUB1 at multiple lysine residues, resulting its association a Legionella-containing vacuole. Lysine promotes interactions between DEPTOR,...
The invasiveness of Salmonella enterica serovar Typhimurium (S. Typhimurium) is closely associated with the pathogenicity island (SPI)-encoded type Ⅲ secretion system (T3SS), which can directly inject a series effector proteins into eukaryotic cells to enable bacterial infection. In this study, syringaldehyde was identified as an effective inhibitor S. T3SS using protein-lactamase fusion reporter system. Syringaldehyde treatment could inhibit expression important (SipA, SipB and SipC) at...
Legionella organisms are ubiquitous environmental bacteria that responsible for human Legionnaires’ disease, a fatal form of severe pneumonia. These replicate intracellularly in wide spectrum host cells within distinct compartment termed the L egionella - c ontaining v acuole (LCV). Effector proteins translocated by Dot/Icm apparatus extensively modulate cellular functions to aid biogenesis LCV and intracellular proliferation. RavZ is an . pneumophila effector as cysteine protease hydrolyze...
Protein ubiquitination is one of the most important post-translational modifications that plays critical roles in regulation a wide range eukaryotic signaling pathways. Many successful intracellular bacterial pathogens can hijack host machinery through action effector proteins are injected into cells by secretion systems.
spp. are the causative agents of a severe pneumonia known as Legionnaires' disease. Upon being engulfed by host cells, these environmental bacteria replicate intracellularly in plasma membrane-derived niche termed
Protein ubiquitination is one of the most important posttranslational modifications (PTMs) in eukaryotes and involved regulation almost all cellular signaling pathways. The intracellular bacterial pathogen Legionella pneumophila translocates at least 26 effectors to hijack host via distinct mechanisms. Among these effectors, SidC/SdcA are novel E3 ubiquitin ligases with adoption a Cys-His-Asp catalytic triad. critical for recruitment endoplasmic reticulum (ER)-derived vesicles...