A5012315249- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Retinopathy of Prematurity Studies
- Neurological Disorders and Treatments
- Traumatic Ocular and Foreign Body Injuries
- Intraocular Surgery and Lenses
- Retinal Diseases and Treatments
- RNA modifications and cancer
- Bacterial biofilms and quorum sensing
- interferon and immune responses
- Heme Oxygenase-1 and Carbon Monoxide
- Ocular Infections and Treatments
- Cancer-related gene regulation
- Connexins and lens biology
- Flavonoids in Medical Research
- Glaucoma and retinal disorders
- Infections and bacterial resistance
- Retinal Imaging and Analysis
Affiliated Hospital of Southwest Medical University
2020-2025
Abstract Objective Retinal vascular endothelial cell (RVECs) injury is a major cause of morbidity and mortality among the patients with diabetes. RVECs dysfunction predominant pathological manifestation complication in diabetic retinopathy. N 6-methyladenosine (m6A) serves as most prevalent modification eukaryotic mRNAs. However, role m6A RNA still unclear. Methods RT-qPCR analysis western blot were conducted to detect change CCK-8 assay, transwell experiment, wound healing tube formation...
Background It is well-known that ultraviolet B (UVB) causes cataracts by inducing pyroptosis and the production of reactive oxygen species (ROS) in human lens epithelial cells (HLECs). The transcription factor E2F1 (E2F1) serves as a positive regulator disrupted pathways involved histone modification cell cycle regulation. However, its function UVB-treated HLECs remains unknown. Purpose: This study aims to investigate HLECs, with particular focus on interaction NLRP3 impact oxidative stress...
Diabetic retinopathy (DR) is a serious retinal vascular disease that affects many individuals in their prime working years. The present research aimed at whether and how LOC681216 (LNC-216) involved dysfunction under diabetic conditions.
<title>Abstract</title> Scleral buckling surgery is often used to repair noncomplex rhegmatogenous retinal detachment. However, postoperative scleral explant infections can cause damage the eye. This report describes two cases of rare ocular microbial after surgery. Two male patients with a history detachment and for more than 10 years presented redness purulent secretions buckle were diagnosed, buckles removed. The first patient experienced coinfection <italic>Pseudomonas...
As one of the most frequent complications diabetes, diabetic neuropathy often involves peripheral and central nervous systems. Neuroinflammation is key pathogenic factor secondary nerve injury in diabetes. NOD-like receptor pyrin domain-containing 3(NLRP3) inflammasome a group subcellular multiprotein complexes, including NLRP3, apoptosis associated speck-like protein(ASC), pro-cysteinyl aspartate specific proteinase 1(pro-caspase-1). NLRP3 an inducer innate immune responses. Its activation...
Axenfeld-Rieger syndrome is an autosomal dominant genetic disease characterized by binocular anterior segment development defects and systemic dysplasia. In our study, a Chinese pedigree was analyzed. After obtaining consent from the subjects, ophthalmic examinations were performed, blood samples collected. Then, causative gene identified targeted next-generation sequencing, candidate mutations verified Sanger sequencing. Pathogenicity analysis conservative performed on mutant to evaluate...