A5102003756- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Nanoparticle-Based Drug Delivery
- Supramolecular Self-Assembly in Materials
- Antimicrobial Peptides and Activities
- Aquaculture disease management and microbiota
- Antibiotic Use and Resistance
- Emergency and Acute Care Studies
- Flavonoids in Medical Research
- Hernia repair and management
- Immune Cell Function and Interaction
- Intestinal and Peritoneal Adhesions
- Surgical Sutures and Adhesives
- Bioactive Compounds and Antitumor Agents
- Immune Response and Inflammation
- Photodynamic Therapy Research Studies
- Axon Guidance and Neuronal Signaling
- Galectins and Cancer Biology
- PI3K/AKT/mTOR signaling in cancer
- Patient Satisfaction in Healthcare
- Nanocluster Synthesis and Applications
Sichuan University
2014-2024
State Key Laboratory of Biotherapy
2014-2024
Southwest University
2019
Ministry of Agriculture and Rural Affairs
2019
Chengdu University
2017-2018
West China Hospital of Sichuan University
2017
United States Department of Veterans Affairs
2015
University of Utah
2015
Centers for Disease Control and Prevention
2015
A novel vaccine adjuvant based on a supramolecular hydrogel of D-tetra-peptide is reported. Antigens can be easily incorporated into the by vortex or gently shaking before injection. The vaccines stimulate strong CD8+ T-cell responses, which significantly inhibits tumor growth. This expected to enable wide range sub-unit and help production antibodies.
Promising vaccine adjuvants of self‐assembling peptide hydrogels for protein ovalbumin (OVA) are introduced in this study. The formed by the enzyme phosphatase, and adjuvant potency both l ‐ d ‐peptide is evaluated. results indicate that, compared with clinically used alum adjuvant, can increase IgG production OVA about 1.3 3.8 times, respectively. Both gels enhance antigen uptake induce dendritic cell maturation, promote prolong accumulation lymph node, as well evoke germinal center...
Abstract To develop injectable formulation and improve the stability of curcumin (Cur), Cur was encapsulated into monomethyl poly (ethylene glycol)-poly (ε-caprolactone)-poly (trimethylene carbonate) (MPEG-P(CL- co -TMC)) micelles through a single-step solid dispersion method. The obtained had small particle size 27.6 ± 0.7 nm with polydisperse index (PDI) 0.11 0.05, drug loading 14.07 0.94% encapsulation efficiency 96.08 3.23%. Both free efficiently suppressed growth CT26 colon carcinoma...
Recently, near-infrared (NIR) light-based photothermal therapy (PTT) has been widely applied in cancer treatment. However, most cases, the tissue penetration depth of NIR light is not sufficient and thus unable to completely eradicate deep, seated tumors inevitably leading recurrence tumor. Due this significant limitation NIR, improved therapeutic strategies are urgently needed. Methods: We developed an endogenous vaccine based on a novel nanoparticle platform for combinatorial ablation...
Activation of the stimulator interferon genes (STING) is essential for blocking viral infections and eliciting antitumor immune responses. Local injection synthetic STING agonists, such as 2′3′-cGAMP [cGAMP = cyclic 5′-guanosine monophosphate (cGMP)–adenosine (AMP)], a promising approach to enhance antiviral functions cancer immunotherapy. However, application agonists has been hindered by complicated procedures, high doses, unsatisfactory systemic Herein, we report design synthesis series...
Despite efforts to reduce antibiotic prescribing for acute respiratory infections (ARIs), information on factors that drive is limited.To examine trends in the Veterans Affairs population over an 8-year period and identify patient, provider, setting sources of variation.Retrospective, cross-sectional study.All emergency departments primary urgent care clinics health system.All patient visits between 2005 2012 with diagnoses ARIs typically had low proportions bacterial infection. Patients or...
The natural flavonoid fisetin (3,3',4',7-tetrahydroxyflavone) was discovered to possess antitumor activity, revealing its potential value in future chemotherapy. However, poor water solubility makes it difficult for intravenous administration. In this study, the monomethyl poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) copolymer applied prepare nanoassemblies of by a self-assembly procedure. prepared micelles gained mean particle size 22 ± 3 nm, polydisperse index 0.163 0.032, drug...
We demonstrated in this study that supramolecular hydrogels of NSAID-modified peptides are promising adjuvants for cancer vaccine development.
Abnormal activation of epidermal growth factor receptor (EGFR) drives non-small cell lung cancer (NSCLC) development. EGFR mutations-mediated resistance to tyrosine-kinase inhibitors (TKIs) is a major hurdle for NSCLC treatment. Here, we show that F-box protein FBXL2 targets and TKI-resistant mutants proteasome-mediated degradation, resulting in suppression EGFR-driven growth. Reduced expression associated with poor clinical outcomes patients. Furthermore, glucose-regulated 94 (Grp94)...
Carbon dots, as vaccine adjuvants, have been firstly engineered for cancer immunotherapy, providing many possibilities biomedical applications.
Abstract Tissue adhesion is a common complication after surgery. In this work, dexamethasone loaded polymeric micelles in thermosensitive hydrogel composite (Dex hydrogel) was prepared, which combined the anti-adhesion barrier with controlled release of drug. Dexamethasone (Dex) encapsulated micelles) and then Dex were into biodegradable hydrogel. The obtained showed temperature-dependent sol-gel-sol phase transition behavior. could form non-flowing gel situ upon subcutaneous injection...
The combination of chemotherapy drugs and multidrug-resistant reversing agents for treating multidrug resistance in tumors has attracted increasing attention. However, the poor water solubility some anticancer restricted their clinical application. In this work, we prepared poly(ethylene glycol)–poly(ε-caprolactone) (MPEG–PCL) micelles as a codelivery system to load drug paclitaxel (PTX) agent tacrolimus (FK506). PTX- FK506-coloaded MPEG–PCL (P-F/M) were by one-step solid dispersion method...
Hydrogel is a promising vaccine delivery vehicle, and have been applied to deliver antigens adjuvants enhance the immunogenicity of antigens. However, complexity hydrogel design, high cost safety hazards immunostimulating prevented widespread applications vaccine. In this study, we developed spontaneously formed self-adjuvanted (SSH) which had both adjuvant potential ability sustained release antigen in situ. Unlike conventional vaccine, our SSH was without requirement radiant light sources...
The combination of chemotherapy drugs attracts more attention in clinical cancer trials. However, the poor water solubility chemotherapeutic restricts their anticancer application. In order to improve antitumor efficiency and reduce side effects free drugs, we prepared paclitaxel (PTX) honokiol (HK) methoxy poly(ethylene glycol)-poly(caprolactone) micelles (P-H/M) by solid dispersion method against breast cancer. particle size P-H/M was 28.7±2.5 nm, transmission electron microscope image...
Abstract Neoantigen‐based immunotherapy is a promising treatment option for many types of cancer. However, its efficacy and abscopal effect are limited by impotent neoantigens, high costs, complications due to action adjuvants. Here, the design synthesis nanovaccines reported, based on self‐adjuvanted, polymer nanoparticles with in vivo neoantigen‐harvesting molecular activating capabilities. These inhibit tumor growth significantly prolong survival tumor‐bearing mice both colon carcinoma 26...
Substantial progress has been made with cancer immunotherapeutic strategies in recent years, most of which mainly rely on enhancing the T cell response. However, sufficient tumor antigen information often cannot be presented to cells, resulting a failed effector The innate immune system can effectively recognize antigens and then initiate an adaptive Here, we developed spontaneous multifunctional hydrogel (NOCC-CpG/OX-M, Ncom Gel) vaccine amplify response harness immunity launch maintain...
Transforming growth factor-β (TGF-β) signaling plays a critical role in promoting epithelial-to-mesenchymal transition (EMT), cell migration, invasion, and tumor metastasis. ΔNp63α, the major isoform of p63 protein expressed epithelial cells, is key transcriptional regulator adhesion program functions as metastasis suppressor. It has been documented that expression ΔNp63α tightly controlled by oncogenic frequently reduced advanced cancers. However, whether TGF-β regulates largely unclear. In...
Neoadjuvant chemotherapy has become an indispensable weapon against high-risk resectable cancers, which benefits from tumor downstaging. However, the utility of chemotherapeutics alone as a neoadjuvant agent is incapable generating durable therapeutic to prevent postsurgical metastasis and recurrence. Herein, tactical nanomissile (TALE), equipped with guidance system (PD-L1 monoclonal antibody), ammunition (mitoxantrone, Mit), projectile bodies (tertiary amines modified azobenzene...
Intraperitoneal adhesion occurs frequently after pelvic and abdominal surgery, which plays an enormous burden on patients. Various drugs barrier agents were studied used to prevent adhesions, but few of them satisfactory. A thermosensitive hydrogel was developed in our previous work effective preventing adhesions. But preliminary experiment, it showed limited activity a more rigorous rat repeated-injury model, much closer clinical. In this study, tissue-type plasminogen activator (tPA)...
Abstract In situ tumor vaccines (ITV) have been recognized as a promising antitumor strategy since they contain the entire tumor‐specific antigens, avoiding cells from evading immune surveillance due to antigen loss. However, therapeutic benefits of ITV are limited by obstacles such insufficient loading, inadequate system activation, and immunosuppressive microenvironments (TME). Herein, microenvironment‐activated hydrogel platform (TED‐Gel) with programmed drug release property is...
Sublancin is a glycosylated antimicrobial peptide produced by Bacillus subtilis 168 possessing antibacterial and immunomodulatory activities. This study was aimed at investigating the effects of sublancin on immune functions serum antibody titer in specific pathogen-free (SPF) broiler chickens vaccinated with Newcastle disease (ND) vaccine. For this purpose, 3 experiments were performed. Experiment 1: SPF chicks (14 days old) randomly allotted to 1 7 groups including blank control (BC),...
Personalized vaccines capable of circumventing tumor heterogeneity have exhibited compelling prospects. However, their therapeutic benefit is greatly hindered by the limited antigen repertoire and poor response CD8+ T-cell immunity. Here, a double-signal coregulated cross-linking hydrogel-based vaccine (Bridge-Vax) engineered to rebuild bridge between innate adaptive immunity for activating T-cells against full antigens. Mechanistically, unlike prominent CD4+ responses in most cases,...