A5088665513- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- Protein Structure and Dynamics
- RNA Research and Splicing
- DNA and Nucleic Acid Chemistry
Poznań University of Technology
2016-2022
Institute of Bioorganic Chemistry, Polish Academy of Sciences
2019-2020
RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of RNA 3D structure prediction. With agreement from crystallographers, structures are predicted by various groups before publication crystal structures. We now report prediction for six sequences: four nucleolytic ribozymes two riboswitches. Systematic protocols comparing models described analyzed. In these puzzles, we discuss (i) comparison between automated web servers human experts; (ii) coaxial stacking;...
Abstract Significant improvements have been made in the efficiency and accuracy of RNA 3D structure prediction methods during succeeding challenges RNA-Puzzles, a community-wide effort on assessment blind tertiary structures. The RNA-Puzzles contest has shown, among others, that development validation computational for fold strongly depend benchmark datasets comparison algorithms. Yet, there no systematic set or decoy structures available RNA, hindering standardization comparative tests...
In modern structural bioinformatics, comparison of molecular structures aimed to identify and assess similarities differences between them is one the most commonly performed procedures. It gives basis for evaluation in silico predicted models. constitutes preliminary step searching motifs. particular, it supports tracing evolution. Faced with an ever-increasing amount available data, researchers need a range methods enabling comparative analysis from either global or local perspective....
Abstract Motivation Knowledge of the 3D structure RNA supports discovering its functions and is crucial for designing drugs modern therapeutic solutions. Thus, much attention devoted to experimental determination computational prediction targeting global fold local substructures. The latter include multi-branched loops—functionally significant elements that highly affect spatial shape entire molecule. Unfortunately, their modeling constitutes a weak point structural bioinformatics. A remedy...
In the world of RNAs and proteins, similarities at level primary structures two comparable molecules usually correspond to structural tertiary level. other words, measures sequence structure are in general correlated - a high value similarity imposes similarity. However, important exceptions that stay contrast this rule can be identified. It is possible find similar with very different sequences, as well sequences structures. paper, we focus our attention on latter case propose tool, called...