A5089302201- Diabetes Management and Education
- Hepatocellular Carcinoma Treatment and Prognosis
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Diabetes Management and Research
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- Mobile Health and mHealth Applications
- Diabetes and associated disorders
- Atrial Fibrillation Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Chronic Disease Management Strategies
- Inflammatory Biomarkers in Disease Prognosis
- Respiratory viral infections research
- Magnolia and Illicium research
- Diabetes Treatment and Management
- Liver Disease and Transplantation
- Respiratory Support and Mechanisms
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Sun Yat-sen University
2013-2025
Third Affiliated Hospital of Sun Yat-sen University
2013-2025
Capital Medical University
2017-2024
Beijing Ditan Hospital
2017-2024
Beijing Anzhen Hospital
2024
Beijing Tian Tan Hospital
2023
Capital University
2023
GTx (United States)
2020
BACKGROUND The efficacy and safety of transarterial chemoembolization (TACE) plus lenvatinib in patients with hepatocellular carcinoma (HCC) portal vein tumor thrombus (PVTT) have not been evaluated. METHODS In this open‐label, single‐center, randomized trial (ClinicalTrials.gov identifier: NCT04127396), participants previously untreated HCC type I‐IV PVTT were 1:1 to receive TACE (arm L; orally once daily, 12 mg for body weight ≥60 kg or 8 <60 kg) sorafenib S; 400 twice daily 28‐day...
Objective As an emerging technology, Android-based open-source closed-loop system also called Android Artificial Pancreas System (AAPS), has been increasingly validated by evidence for its effectiveness in improving glycaemic outcomes, positioning it as a crucial option managing type 1 diabetes (T1D). However, there are still only few studies examining the experiences of using AAPS, and relevant qualitative have not conducted Asia so far. This study aimed to explore opinions adult patients...
ABSTRACT Aim To explore the barriers and facilitators to physical activity engagement among people with young‐onset type 2 diabetes. Design A qualitative research design using individual semi‐structured interviews. Methods purposive sampling technique was used recruit individuals diabetes through social media, based on: age, gender, duration, complication level. Interviews were audio recorded, transcribed verbatim analysed Framework analysis integrating Capability, Opportunity, Motivation...
Liposomal honokiol isolated from the genus Magnolia has been found to have antiangiogenic, anti-inflammatory and antitumor properties. However, there no report on its role in hair growth. Hair follicles are life-long cycled organelles that go through anagen, catagen telogen stages regulated by diverse signaling pathways, including Wnt/β-catenin, Notch, Epidermal growth factor (EGF) Sonic hegehog (SHH). Wnt signals essential for initiation of follicle placode development a new potential...
Abstract HH‐120, a recently developed IgM‐like ACE2 fusion protein with broad‐spectrum neutralizing activity against all ACE2‐utilizing coronaviruses, has been as nasal spray for use an early treatment agent to reduce disease progression and airborne transmission. The objective of this study was evaluate the safety efficacy HH‐120 in SARS‐CoV‐2‐infected subjects. Eligible symptomatic or asymptomatic participants were enrolled single‐arm trial receive no longer than 6 days until viral...
Recently, combination therapy has shown a better trend towards improved tumour response and survival outcomes than monotherapy in patients with hepatocellular carcinoma (HCC). However, research on triple [lenvatinib + sintilimab transarterial chemoembolization (TACE)] as first-line treatment for advanced HCC is limited.
BACKGROUND:Coronavirus disease 2019 (COVID-19) is a new infectious disease, and acute respiratory syndrome (ARDS) plays an important role in the process of aggravation. The detailed clinical course risk factors ARDS have not been well described. MATERIAL AND METHODS:We retrospectively investigated demographic, clinical, laboratory data adult confirmed cases COVID-19 Beijing Ditan Hospital from Jan 20 to Feb 29, 2020 compared differences between non-ARDS cases. Univariate multivariate...
Hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) portends a worse prognosis. The objective of this study was to compare the efficacy percutaneous radiofrequency ablation (RFA) combined transarterial chemoembolization (TACE) plus sorafenib that most commonly utilized regimen TACE in large HCCs type I/II PVTT.An open-label, single-center, prospective, randomized trial participants tumors ≥5 cm and PVTT performed. Participants previously untreated were divided into two...
Up to 85% of hepatocellular carcinoma (HCC) cases in China can be attributed infection hepatitis B virus (HBV). Lipid metabolism performs important function hepatocarcinogenesis HBV-related liver carcinoma. However, limited studies have explored the prognostic role lipid HCC. This study established a model stratify HCC based on metabolisms.Based The Cancer Genome Atlas samples, this selected prognosis-related genes and prognosis risk by performing uni- multi-variate Cox regression methods....
Abstract Background Both COVID-19 and influenza A contribute to increased mortality among the elderly those with existing comorbidities. Changes in underlying immune mechanisms determine patient prognosis. This study aimed analyze role of lymphocyte subsets immunopathogenesisof severe A, examined clinical significance their alterations prognosis recovery duration. Methods By retrospectively reviewing patients four groups (healthy controls, non-severe COVID-19) who were admitted Ditan...
To investigate the dietary knowledge, attitude and practice (KAP) among family members (FMs) of Chinese type 2 diabetes mellitus (T2DM) patients its influence on KAP T2DM patients.Two hundred thirty-six pairs hospitalized their FMs (472 in total) our hospital were enrolled. A pair self-designed questionnaires (Cronbach's α ≥ 0.763, I-CVI 0.857, S-CVI = 0.964, 0.958) used to collect data assess towards diets.The mean score for was 2.33 ± 0.60, 3.03 0.44 2.77 0.38, whereas that 2.37 0.55, 3.08...
The main aim of this study was to evaluate a combined fasting blood glucose based dosage self-titration setting and decision supported telephone coaching intervention on glycemic control diabetes self-management skills, compared the conventional care.A 12-week, single-blinded, randomized controlled trial conducted adults with type 2 (T2DM) primarily treated basal insulin. After randomization, group (IG, n = 426) received insulin support administered by Diabetes Specialty Nurses while (CG,...
Health literacy, empowerment, and self-care activities are likely the crucial concepts affecting quality of life glycemic control in people with type 2 diabetes (T2D). However, evidence demonstrating mechanisms underlying these is scarce.
Abstract Background Direct oral anticoagulants (DOACs) have become the first-line therapy for ischaemic stroke prevention in atrial fibrillation (AF) patients. Data on effectiveness and safety of single DOAC large Chinese populations are scarce. Purpose We firstly present one-year outcome data edoxaban treatment 5001 AF Methods This is a multi-centre, prospective, observational study, ETNA-AF-China, conducted 89 centres from four economic regions Mainland China with follow-up two years....
Abstract Background In China and many other countries, anticoagulated atrial fibrillation (AF) patients with high bleeding risk often raises clinical concern; the optimal dose of direct oral anticoagulants (DOACs) preventing stroke/systemic embolic events (SEE) in those population remains unclear. Purpose To assess effectiveness safety edoxaban treatment Chinese AF risk, to compare 60 mg vs 30 this real-world registry. Methods ETNA-AF-China is a prospective, observational study conducted 89...
This study aimed to investigate the role of neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) in unresectable hepatocellular carcinoma (HCC) patients treated with tyrosine kinase inhibitors (TKIs) immune checkpoint (ICIs). The optical cutoff values NLR PNI were determined via time-dependent receiver operating characteristic curve analysis. associations between overall survival (OS) various potential risk factors analyzed. Forty-nine HCC enrolled this retrospective...
Introduction Individuals with pre-diabetes are at high risk for developing type 2 diabetes mellitus (T2DM), which makes them prone to serious complications such as stroke, kidney failure, blindness and lower-limb amputation. Pre-diabetes can be reversed, lifestyle modification is considered the best intervention method prevention. However, it difficult individuals maintain a long-term modified healthy owing psychological burnout in daily management over time due poor adherence. We developed...
Abstract HH‐120, an IgM‐like angiotensin converting enzyme 2 (ACE2) fusion protein, has been developed as a nasal spray against Severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) and is currently undergoing human trials. HH‐120 was assessed for postexposure prophylaxis (PEP) in two investigator‐initiated (NS01 NS02) trials with different risk levels of SARS‐CoV‐2 exposure. NS01 enrolled family caregiver participants who had continuous contacts laboratory‐confirmed index cases; NS02...
Objective To review the clinical features of acute drug-induced liver injury. Methods The data 230 patients with injury admitted to Beijing Ditan Hospital from October 2005 May 2011 were retrospectively analyzed. Results In patients, more than 60% had symptoms fatigue, anorexia, jaundice and damage presenting LT, AST, ALP TBIL changes. The hepatocellular type accounted for 80.4% (185/230), cholestatic 11.7% (27/230) mixed 7.8% (18/230). Chinese herbal medicine or patent was most...
Objective: To investigate the safety and efficacy of radiofrequency ablation (RFA) with percutaneous iohexol-ethanol injection (PIEI), compared RFA plus transcatheter arterial chemoembolization (TACE) for patients primary liver cancer(PLC)in high-risk locations. Methods: From January 2012 to December 2014, 54 PLC in locations were enrolled. They divided into Group A (RFA combined PIEI) B TACE). The adverse events assessed. Results: had 74 lesions There 26 cases 40 A, 28 34 B. complete rate...
Abstract Background: Both COVID-19 and influenza A contribute to increased mortality among the elderly those with existing comorbidities. Changes in underlying immune mechanisms determine patient prognosis. This study aimed analyze role of lymphocyte subsets immunopathogenesisof severe A, examined clinical significance their alterations prognosis recovery duration. Methods: By retrospectively reviewing patients four groups (healthy controls, non-severe COVID-19) who were admitted Ditan...