A5087814519- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Neonatal and Maternal Infections
- Streptococcal Infections and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Sepsis Diagnosis and Treatment
- Pelvic floor disorders treatments
- Vaccine Coverage and Hesitancy
- Immune cells in cancer
- Urinary Bladder and Prostate Research
- T-cell and B-cell Immunology
- Hepatitis B Virus Studies
- Atrial Fibrillation Management and Outcomes
- Healthcare Policy and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Hepatitis C virus research
- Long-Term Effects of COVID-19
- Global Health Care Issues
- Inflammasome and immune disorders
Hubei University of Medicine
2022-2025
Affiliated Hospital of Southwest Medical University
2025
Henry Ford Health System
2018-2024
Weifang Medical University
2024
West China Medical Center of Sichuan University
2024
Yangzhou University
2024
Guangxi Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Shandong First Medical University
2023
Shandong Tumor Hospital
2023
Real-world evidence on inactivated COVID-19 vaccines against the highly transmissible B.1.617.2 (Delta) variant of SARS-CoV-2 is limited, leaving an important gap in base about for use by immunization programs.
Various methods for editing specific sites in the Escherichia coli chromosome are available, and gene-size (∼1 kb) integration into a single site or to introduce deletions, short insertions point mutations multiple can be conducted period of time. However, method rapidly integrating sequences different has not been developed yet. Here, we describe plasmid system that makes it possible simultaneously insert genes loci E. genome without need chromosomal markers. The uses CRISPR-Cas12a...
The vacuolar-type H
The onset of sepsis frequently coincides with acute respiratory distress syndrome (ARDS), which constitutes a significant contributor to severe acid–base disturbances in septic patients. In the pathogenesis sepsis, it conducts crucial role. lysosomal metabolic disorders and immune imbalance conduct pivotal Despite extensive research into alterations status during few studies have been reported thoroughly examine association between lysosomes sepsis. As result, this study is predominantly...
Infection of human peripheral blood cells by SARS-CoV-2 has been debated because immune lack mRNA expression both angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease type (TMPRSS2). Herein we demonstrate that resting primary monocytes harbor abundant cytoplasmic ACE2 TMPRSS2 protein circulating exosomes contain significant protein. Upon ex vivo TLR4/7/8 stimulation, was quickly translocated to the monocyte cell surface independently transcription, while translocation...
Background: Real-world evidence (RWE) of a vaccine supplements clinical trial data by providing information in populations differing from populations, under different epidemiological situations, on alternative outcomes, or against pathogen lineages. To date, RWE inactivated COVID-19 vaccines the highly transmissible SARS-CoV-2 B.1.617.2 (Delta) variant is limited, leaving an important gap base for use immunization programs. Methods: Between May and June 2021, outbreak was discovered traced...
Background: The mainstream medications for rheumatoid arthritis (RA) include conventional disease-modifying antirheumatic drugs (cDMARDs), which mostly are methotrexate (MTX), and biologic agents such as adalimumab (ADA), certolizumab (CZP), etanercept (ETN), golimumab (GOL), infliximab (IFX) tocilizumab (TCZ). This network meta-analysis was aimed at evaluating the efficacy safety of above interventions combining cDMARDs patients with RA. Methods: PubMed, EMBASE, Cochrane Library...
Transcutaneous electrical neural stimulation (TENS), as a non-invasive modality, has been clinically used an alternative treatment for children with overactive bladder (OAB). We conducted pooled analysis to explore the effect of TENS on OAB.The Preferred Reporting Items Systematic Reviews and Meta-analysis guideline was followed in this study. The MEDLINE, Embase, Cochrane Central Register Controlled Trials databases, well reference lists retrieved studies, were find trials relevant...
Abstract Background Townes-Brocks syndrome (TBS) is a rare genetic disorder characterized by imperforate anus, dysplastic ears, thumb malformations, and other abnormalities. Previous studies have revealed that mutations in the SALL1 gene can disrupt normal development, resulting characteristic features of syndrome. Spalt-like transcription factors (SALLs) are highly conserved proteins play important roles various cellular processes, including embryonic cell differentiation, survival. Over...
Abstract Background Atrial fibrillation (AF) is highly correlated with heart failure, stroke and death. Screening increases AF detection facilitates the early adoption of comprehensive intervention. Long-term wearable devices have become increasingly popular for screening in primary care. However, interpreting data obtained by long-term ECG a problem To diagnose disease quickly accurately, we aimed to build episode model based on nonlinear Lorenz scattergram (LS) deep learning. Methods The...
Patients with coronary artery disease (CAD) at low residual inflammatory risk are often overlooked in research and practice. This study examined the associations between fourteen indicators all-cause mortality 5,339 CAD patients baseline high-sensitivity C-reactive protein (hsCRP) <2 mg/L who received percutaneous intervention statin aspirin therapy. The median follow-up time was 2.1 years. Neutrophil-derived systemic response index (SIRI) yielded strongest most robust association among all...
It was previously reported in China that two recent large-scale outbreaks of Streptococcus suis serotype 2 (S. 2) infections human were caused by highly virulent S. strains, from which a novel genomic island (GEI), associated with disease onset and progression designated 89 K, identified. Here, an avirulent strain, 05HAS68, isolated clinically healthy pig. By comparing the genomes this strain it found massive rearrangements occurred, resulting alterations gene expression enormous single gain...
This study explored the ability of high-sensitivity C-reactive protein (hs-CRP) and glycosylated hemoglobin A1c (HbA1c) to predict adverse cardiac cerebrovascular outcomes in patients with chronic coronary syndromes (CCS) undergoing percutaneous intervention (PCI).
Objective: Analysis of clustering characteristics coronavirus disease 2019 (COVID-19) in Guangdong Province. Methods: The COVID-19 cases Province onset from January 1 to February 29, 2020 were collected Chinese information system for control and prevention Emergency Public Reporting System. Obtain the epidemiological survey data cluster epidemic situation, clarify scale index cases, family non-family subsequent cases. Calculate serial interval according time secondary attack rate based on...
Abstract Background Direct oral anticoagulants (DOACs) have become the first-line therapy for ischaemic stroke prevention in atrial fibrillation (AF) patients. Data on effectiveness and safety of single DOAC large Chinese populations are scarce. Purpose We firstly present one-year outcome data edoxaban treatment 5001 AF Methods This is a multi-centre, prospective, observational study, ETNA-AF-China, conducted 89 centres from four economic regions Mainland China with follow-up two years....
Introduction Non-alcoholic fatty liver disease (NAFLD) is a common chronic seriously threatening human health, with limited treatment means, however. Sesamin, lignan in sesame seed oil, exhibits anti-inflammatory, antioxidant, and anticancer properties. Our previous studies have shown an ameliorative effect of sesamin on lipid accumulation hepatocellular carcinoma (HePG2) induced by oleic acid, its protective effects unclear the case 9-trans-C18:1 elaidic acid (9-trans-C18,1). Methods L02...
The mounting volume of construction waste in China has been steadily rising over the years, yet largely overlooked. environmental Kuznets curve offers a theoretical framework for understanding management by illustrating relationship between economic development and degradation. This paper applies concept to China’s generation, utilizing per capita gross domestic product as indicators, respectively. Panel data from 31 Chinese provinces, municipalities, autonomous regions spanning 2000 2022...
<title>Abstract</title> <bold>Purpose:</bold>This study aims to assess the impact of dietary factors on osteoporosis prevalence within a natural population in Sichuan, China, establish foundation for future intervention strategies. <bold>Methods</bold>: Participants were drawn from prospective cohort centered selecting representative sites and employing cluster random sampling execute projects across various locations Southwestern China. This approach enabled collection data populations with...