In select patients with type C esophageal atresia, primary anastomosis is not appropriate and a staged approach required. We aim to summarize our experience in the management of EA using approach. A retrospective chart-review admitted Beijing Children's Hospital between July 2020 October 2023 were conducted. Those diagnosed who amendable included for analysis. Clinical information was recorded, follow- up performed. Seven (five boys) received repair study. Initial surgeries thoracotomy...

Ground cover rice production system (GCRPS), i.e., paddy soils being covered by thin plastic films with soil moisture maintained nearly saturated status, is a promising technology as increased yields are achieved less irrigation water. However, aeration and temperature under GCRPS may cause pollution swapping in greenhouse gas (GHG) from CH4 to N2O emissions. A 2-year experiment was performed, taking traditional cultivation reference, assess the impacts of N-fertilizer placement methods on...

The overexpressed soluble fms‐like tyrosine kinase 1 (sFLT‐1) in placenta is considered to be a potential therapeutic target for PE. How achieve efficient intervention of sFLT1 expression the an urgent problem solved. PEG-PLA nanoparticle generated by double-emulsion methods novel siRNA delivery system. Synthetic placental CSA binding peptide (P-CSA-BP) effective targeting lipid-polymer placenta. We conjugated P-CSA-BP surface create specific system therapy preeclampsia (PE). Nanoparticles...

Abstract Background The aim of this study was to explore the clinicopathological characteristics recurrent adult-type granulosa cell tumor ovary (AGCOT) and evaluated treatment results define prognostic parameters for survival after recurrence. Results A retrospective review 40 patients with AGCOT, who were treated in Cancer Hospital at Chinese Academy Medical Sciences from 2000 2015 conducted. impact clinical pathological characteristics, progression-free (PFS), post-recurrence therapeutic...

Objectives: To evaluate the effects and safeness of combined hysterolaparoscopy on evaluation causes infertility. Methods: This retrospective study was conducted at Department Gynecology (The Third Affiliated Hospital Sun Yat-Sen University, Guangzhou, Guangdong, China) from January 2011 to April 2014. Patients aged 21–43 years with infertility were included in this study. The prevalence different lesions collected analyze. Results: 132 infertile patients included, 71 (53.8%) women had...

OBJECTIVE Spontaneous paralysis from hourglass-like fascicular constriction of peripheral nerves is rare, its clinical manifestations are not well documented, and pathogenesis remains unknown. The unclear origin this disorder difficulty in diagnosis result uncertain management. authors sought to gain a more thorough understanding condition through describing the anatomy, features, etiology, treatment constriction. METHODS retrospectively reviewed 20 patients (22 nerves) with patients’...

Given that mutations related to maturity-onset diabetes of the young (MODY) are rarely found in Chinese populations, we aim characterize mutation spectrum MODY pedigrees.Maturity-onset candidate gene- or exome-targeted capture sequencing was carried out 76 probands from unrelated families fulfilling clinical diagnostic criteria for MODY. MAF <0.01 GnomAD ExAC database used filter significant variants. Sanger then validate findings. Function prediction by SIFT, PolyPhen-2 and PROVEAN CADD...

BackgroundStatins are thought to have pleiotropic properties, including anticoagulant effects, in addition reducing lipoprotein (LDL) levels. Plasma extracellular vesicles (EVs) small bilayer membrane involved various biological processes coagulation. Since subsets of EVs the LDL plasma fraction (LDL-EVs) correlate with thrombin activity, we hypothesized that changes LDL-EVs after statin therapy may differ from serum levels coagulation proteins, providing insight into effects statins on...

In general, at the same level of exercise, female athletes are three to six times more likely injure an anterior cruciate ligament (ACL) than male athletes. Female also had higher rates ACL injury males in a single-leg landing task after backcourt backhand side overhead stroke badminton. many previous studies, stiffness musculoskeletal system lower limbs has been reported as potential factor contributing differences between genders. The purpose this study was describe genders leg and knee...

<h3>Objective</h3> To analyze the clinical characteristics, diagnosis, and treatment of ovarian juvenile granulosa cell tumor. <h3>Methods</h3> The pathological data six patients with tumor was collected. <h3>Results</h3> mean age disease onset 20.5 years (range 12 to 33). All had an adnexal mass located laterally in pelvis, two developed ascites. fertility-sparing surgery complete staging. size tumors 15.3 cm 5 35). Ovarian sex cord stromal were diagnosed or highly suspected from frozen...

Abstract Purpose Few studies have reported the impact of clinical response patients with Esophageal Carcinoma to chemoradiotherapy (CRT). Our study examines association between and pretreatment variables, survival, patterns failure, benefit consolidation chemotherapy in subjects esophageal squamous cell carcinoma (ESCC) receiving CRT. Methods Data from ESCC treated at Shandong Cancer Hospital January 2013 December 2016 were analyzed retrospectively. By definition, we considered a poor as...

Kugel hernia repair is classically carried out through the posterior approach; in this study we investigated effectiveness and invasiveness of a Modified (Bard‐Davol Inc., RI, USA) procedure an anterior approach. A prospective series covering 2‐year period, including 122 patients (142 hernias) were using Patient comfort, complications recurrence evaluated. total 142 inguinal hernias repaired, median age was 67 years, mean operation time 51 ± 23 min average incision 4.5 cm. There one case 5...

To investigate the efficacy of ropivacaine and bupivacaine in caesarean section vital signs hemodynamics lying-in women.A total 480 women who were admitted to this hospital for treatment between December 2017 June 2018 enrolled into study as subjects, which divided experiment group control group, with 240 subjects each group. In received local anesthesia by infusion 1.5 mL (0.75%), while those also took (0.75%). Thereafter, we observed differences anesthetic efficiency, two groups.The...

Background Biliary atresia (BA) is the most common form of severe neonatal obstructive jaundice. The etiology and pathogenesis BA are multifactorial, different factors may interact to produce heterogeneous pathological features clinical outcomes. Despite features, all patients received same treatment strategy. This study performed integrative clustering analysis based on multiple high-throughput datasets identify molecular subtypes provide a new strategy for personalized BA. Methods RNA...

Exposure to phthalate acid esters (PAEs) has been found have adverse effects on reproduction of human and animal. However, the semen quality are controversial. In this study, we collected paired blood sperm samples from patients (n = 103) at a medical clinic in Guangzhou, China, determine concentrations eight metabolites (m-PAEs). The concentration ranges ∑8m-PAEs were 2.7–55 0.99–17 ng/mL samples, respectively. MEHP (median, 3.6 0.55 semen) MnOP 3.4 0.69 predominant analytes both samples....

Recurrent tracheoesophageal fistula (rTEF) is a rare complication following initial esophageal atresia (EA) surgical repair, posing challenges in localization the during surgery due to severe thoracic adhesions and structural ambiguity from previous operations. We introduced two new methods for rTEF patients aimed compare impact of using these techniques versus not them on outcomes patients. retrospectively analyzed clinical data cases that underwent thoracoscopic repair at our hospital...

MicroRNAs (miRs) post‑translationally regulate gene expression by specifically binding to the mRNA of their target genes. The aim present study was determine effect miR‑192 on pancreatic β‑cell development. serum levels in type 1 diabetes mellitus (T1DM) and streptozotocin‑induced rats were determined, revealed be elevated compared with those healthy patients normal rats, respectively. Western blot reverse transcription‑quantitative polymerase chain reaction analysis indicated that...