A5102296789- Pregnancy and preeclampsia studies
- MicroRNA in disease regulation
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- dental development and anomalies
- Bone and Dental Protein Studies
- Renal and related cancers
- Circular RNAs in diseases
- Reproductive System and Pregnancy
- Global Maternal and Child Health
- Demographic Trends and Gender Preferences
- Oral and Maxillofacial Pathology
- Radiation Dose and Imaging
- Bone health and osteoporosis research
- Cardiovascular Disease and Adiposity
- Maternal and fetal healthcare
- Periodontal Regeneration and Treatments
- Oral microbiology and periodontitis research
- Congenital heart defects research
- Machine Fault Diagnosis Techniques
- Electronic Health Records Systems
- Preterm Birth and Chorioamnionitis
- Healthcare Systems and Technology
- Engineering Structural Analysis Methods
- Kruppel-like factors research
The Affiliated Yongchuan Hospital of Chongqing Medical University
2018-2024
Chongqing Medical University
2018-2024
Civil Aviation Flight University of China
2023
Children's Hospital of Chongqing Medical University
2019-2020
Chongqing Public Health Medical Center
2019
University of Leicester
2018
Air Force Medical University
2008-2016
Normal placentation and a successful pregnancy depend on appropriate trophoblast cell migration invasion. Inadequate invasion impaired spiral artery remodeling may lead to pregnancy-related disorders, such as preeclampsia. RPS4Y1 (ribosomal protein S4, Y-linked 1) is member of the S4E family ribosomal proteins. In this study, we found that levels were upregulated in placental samples collected from preeclamptic patients, when compared with normotensive pregnant women. vitro, inhibition...
Periodontitis is an oral inflammatory disease that not only affects the integrity of local tooth-supporting tissues but also impacts systemic health. A compositional shift in microbiota has been considered as main cause periodontitis; however, potential mechanism fully defined. Herein, we investigated role CCAAT/enhancer-binding protein β (C/EBP β), a member C/EBP family transcription factors, human periodontal ligament cells (hPDLCs) exposed to Porphyromonas gingivalis (P. gingivalis)...
To identify the profiles of circular RNAs (circRNAs) in human placental tissues and to explore potential roles dysregulated circRNAs pathological genesis preeclampsia, expression placentas were performed this study.Utilizing high-throughput technology, based on fold changes P values, 300 that are differentially expressed between preeclampsia normal identified.Among them, hg38 circ 0014736 hsa 0015382 validated as significantly upregulated by real-time quantitative PCR with divergent...
Background: A recent study has reported that maternal obesity is linked to placental oxidative damage and premature senescence. NADPH oxidase 4 (NOX4) massively expressed in adipose tissue, its induced reactive oxygen species have been found contribute cellular While, whether, obese pregnancy, tissue-derived NOX4 the considerable cause of senescence remained elusive. Methods: This collected term placentas from normal pregnancies pregnant mouse model was constructed by a high fat diet explore...
Successful pregnancy requires normal placentation, which largely depends on the tight regulation of proliferation, invasion, and migration trophoblast cells. Abnormal functioning cells may cause failure uterine spiral artery remodeling, be related to pregnancy-related disorders, such as preeclampsia. Here, we reported that an actin-binding protein, α-actinin (ACTN)4, was dysregulated in placentas from early onset Moreover, knockdown ACTN4 markedly inhibited cell proliferation by reducing AKT...
Special AT-rich sequence binding protein 1 (SATB1) play potential roles in invasion and metastasis of tumor cells, involves human placental fetal development. The objective this study is to explore the role SATB1 migration trophoblast mechanism.Human tissues from first trimester, second term, preeclampsia (PE) pregnancies were used detect expression subcellular location β-catenin. cell line HTR8/SVneo, which was treated with hypoxia/re-oxygenation (H/R), lithium chloride (LiCl) or...
Abstract Fetal growth restriction (FGR) is a condition in which newborn fails to achieve his or her prospective hereditary potential. This associated with high mortality, second only that premature birth. FGR maternal, fetal, and placental abnormalities. Although the placenta considered be an important organ for supplying nutrition fetal growth, research on limited, treatment through remains challenging, as neither proper uterine intervention nor its pathogenesis have been fully elucidated....
Preeclampsia (PE) is characterized by abnormal placentation in the early stages of pregnancy. Adequate migration and invasion trophoblasts into uterine wall spiral arteries to form a functional maternal–fetal interface are pivotal for normal placentation, but exact mechanism remains unclear. Growing evidence has revealed that special AT-rich sequence binding protein 1 (binds nuclear matrix/scaffold-associating DNA) (SATB1) tumor promoter participates cancer cell invasion. However, expression...
Abstract In China, the adjustment of family planning policy was expected to increase number births and trigger a change in demographic obstetrical background pregnant women. The itself, corresponding variations mothers, might have various influences on certain birth-related characteristics. Moreover, adaption medical system needs be demonstrated. To address these issues, over 50,000 individual records from January 2012 December 2018 were collected large tertiary care centre southwest China...
Spontaneous preterm birth (sPTB) is the leading cause of infant morbidity and mortality worldwide. Deficiency effective predict methods an urgent problem that needs to be solved. Numbers researchers spare no efforts investigate differential indicators. To evaluate value indicators, a prospective nested case-control study was carried out. Among overall cohort 1,050 pregnancies, 20 sPTB full-term pregnancies were enrolled in this study. Participants followed-up until labor. The psychological...
Preeclampsia is characterized by new onset of hypertension and proteinuria after 20 weeks' gestation a leading cause maternal neonatal morbidity mortality. The pathogenesis preeclampsia often associated with aberrant trophoblast function that leads to shallow placental implantation. However, the exact underlying mechanisms remain unclear. Placental LncZBTB39-1:2 expression level was investigated in healthy placentae using qRT-PCR, metabolic profile trophoblasts overexpressing vitro analysed...
Objective This study aims to investigate the risk factors for severe postpartum hemorrhage (SPPH) in patients with placenta accreta spectrum (PAS) undergoing cesarean delivery, despite prophylactic use of resuscitative endovascular balloon occlusion aorta (REBOA).
Bearing failure is one of the common faults in general aviation piston engines, which directly affects stability and safety aircraft. The existing diagnostic methods are manual visual fault detection, accuracy greatly by worker experience has low efficiency. To address aforementioned shortcomings, an automatic diagnosis method based on deep learning networks proposed to achieve intelligent detection bearing this paper. adopts improved YOLOv5 model process photos bush during engine...
Abstract Background Preeclampsia (PE) is defined as new-onset hypertension with proteinuria or end-organ dysfunction after 20 weeks of gestation. Defective placentation due to dysregulated behaviors trophoblast cells considered a predominant cause PE. Recently, increasing evidence has suggested an association between microRNAs and PE progression. This study aims explore the effect miR-101-5p on cell function pathogenesis Methods Quantitative real-time PCR (qRT-PCR) fluorescence in situ...