A5102003927- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Gut microbiota and health
- Neuroscience and Neural Engineering
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Trace Elements in Health
- Nicotinic Acetylcholine Receptors Study
- Cancer-related molecular mechanisms research
- Protease and Inhibitor Mechanisms
- Regional Development and Environment
- Estrogen and related hormone effects
- Chronic Myeloid Leukemia Treatments
- Genomics and Phylogenetic Studies
- Memory and Neural Mechanisms
- Inflammatory Bowel Disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Dementia and Cognitive Impairment Research
- Migraine and Headache Studies
- Extracellular vesicles in disease
- Educational Reforms and Innovations
- Heat Transfer Mechanisms
- Systemic Sclerosis and Related Diseases
- Diet and metabolism studies
Zhongda Hospital Southeast University
2016-2025
Nanjing University of Chinese Medicine
2021-2025
Henan University of Science and Technology
2025
Northeast Agricultural University
2025
Shuguang Hospital
2024
Shanghai University of Traditional Chinese Medicine
2024
Affiliated Hospital of Jiangsu University
2024
Chongqing Municipal Health Commission
2024
Jiangsu University
2024
Northwestern Polytechnical University
2024
Background: Stroke is a leading cause of adult disability that can severely compromise the quality life patients, yet no effective medication currently exists to accelerate rehabilitation. A variety circular RNA (circRNA) molecules are known function in ischemic brain injury. Lentivirus-based expression systems have been widely used basic studies circRNAs, but safety issues with such delivery limited exploration potential therapeutic roles for circRNAs. Methods: Circular SCMH1 (circSCMH1)...
Background:Although progress has been made in the detection and characterization of neural plasticity depression, it not fully understood individual synaptic changes circuits under chronic stress antidepressant treatment.
Depression, a prevalent psychiatric disorder of ambiguous etiology and high heterogeneity, has been recently linked to the primary visual cortex (V1). However, precise circuits mediating impact V1 on depressive-like behaviors are poorly understood. Here, we demonstrate that V1, specifically lateral posterior nucleus thalamus (LP)-projecting glutamatergic subpopulation (GluV1→LP neurons), shows reduced activity after chronic restraint stress (CRS) in male mice, leading behaviors. Optogenetic...
Tau hyperphosphorylation is an important pathological feature of Alzheimer's disease (AD). To investigate whether escitalopram could inhibit amyloid-β (Aβ)-induced tau and the underlying mechanisms, we treated rat primary hippocampal neurons with Aβ1-42 examined effect on hyperphosphorylation. Results showed that decreased Aβ1-42-induced In addition, activated Akt/GSK-3β pathway, PI3K inhibitor LY294002 blocked attenuation induced by escitalopram. Moreover, 5-HT1A receptor agonist 8-OH-DPAT...
1. Melan-A (MLANA) plays a key role in the development of melanosome, making it strong candidate for pigmentation phenotype observed animals. The main purpose this study was to analyse relationship between MLANA gene polymorphisms and tyrosinase (TYR) enzyme activity skin tissues melanin content dorsal down feathers Chinese yellow quail.2. coding sequence region mRNA cloned sequenced detect polymorphisms. 266 quails analysed by spectrophotometry, TYR measured tissues. expression individuals...
Clonal haematopoiesis of indeterminate potential (CHIP) can increase the risk myocardial infarction (MI). Among various CHIP mutations, JAK2 V617F substantially elevated this risk. However, specific associations between and two mechanisms MI, plaque erosion rupture, remain unclear. Case-control studies investigated these associations. A total 728 cases, 919 rupture 804 controls were included from our centre. Digital-drop polymerase chain reaction was performed on individuals to identify...
// Xiang Tang 1,* , Di Wu Li-Hua Gu 1 Bin-Bin Nie 2 Xin-Yang Qi Yan-Juan Wang Fang-Fang Xiao-Li Li Feng Bai Xiao-Chun Chen 3 Lin Xu 4,5 Qing-Guo Ren and Zhi-Jun Zhang Department of Neurology, Affiliated ZhongDa Hospital, Neuropsychiatric Institute, School Medicine, Southeast University, Nanjing, Jiangsu, China Key Laboratory Nuclear Analytical Techniques, Institute High Energy Physics, Chinese Academy Sciences, Beijing, Neurology Geriatrics, Fujian Medical University Union Fuzhou, Fujian, 4...
Magnetic brain stimulation has greatly contributed to the advancement of neuroscience. However, challenges remain in power penetration and precision magnetic stimulation, especially small animals. Here, a novel combined system (c-MSS) was established for mice. The c-MSS uses mild pulse sequence injection superparamagnetic iron oxide (SPIO) nanodrugs elevate local cortical susceptibility. After imaging SPIO nanoparticles left prelimbic (PrL) cortex mice, we determined their safety physical...
Precise evaluation of the efficacy immunotherapy is critical in effective management and treatment advanced hepatocellular carcinoma (HCC). Therefore, purpose this study was to compare response assessments achieved by different criteria evaluate correlation between survival outcome assessment HCC treated with programmed cell death protein 1 (PD-1) inhibitor. Fifty patients first-line PD-1 inhibitor baseline follow-up CT images were analyzed. The categorized into responders nonresponders...
Background: The causal relationship between gut microbiota and peripheral artery disease (PAD) is still not clear. In this research, we employed the Mendelian randomization (MR) technique to explore potential connection 211 species PAD. We also investigated whether effects operate in both directions. Methods: used Genome-wide Association Studies (GWAS) summary statistics data from MiBioGen FinnGen consortia conduct a two-sample MR analysis link Sensitivity conducted assess robustness of...
Background Epidermal growth factor receptor (EGFR) gene mutations predict tumor response to EGFR tyrosine kinase inhibitors (EGFR‐TKIs) in non‐small cell lung cancer (NSCLC). However, even patients with ‐sensitive NSCLC have limited efficacy EGFR‐TKI. Studies shown that long noncoding RNA (lncRNA) is related diagnosis and prognosis NSCLC. This study aimed explore the correlation between lncRNA mutation status EGFR‐TKI efficacy. Methods The amplification‐refractory system method was used test...
Abstract Introduction The two‐pore domain potassium channel TREK‐1 is a member of background K + channels that are thought to provide baseline regulation membrane excitability. Recent studies have highlighted the putative role in action antidepressants, and its antagonists might be potentially effective antidepressants. However, mechanisms underlying actions not yet fully understood. Methods expression was examined mouse model chronic unpredictable mild stress (CUMS) using immunoblotting....
The high-speed and high-temperature gap leakage flow in the turbine blade tip clearance directly scours of rotor generates a local region, so active passive control is very important. Based on pressure sensitive paint (PSP) experiment, effects density ratio, blowing height film cooling characteristics squealer were studied. results show that with increase film-cooling effectiveness gradually increases, especially large height, average effect increased by 35%. ratio surface not single. Under...
Abstract By using the concept of Territorial Spatial Planning, this paper constructed framework water ecological security evaluation territorial space in mountain cities, based on perspectives Macro-, Medium- and Micro-, 3 levels “Water-soil, Water-city, Water-net”. Establish method mountainous city with “3 levels, 4 characteristics, 6 dimensions 12 actions”, by combining basic disciplines “ecology, environment security”, focusing core functions ”water-soil conservation, water-city...
Emerging evidence suggests that dysfunctional visual cortex maybe involved in the pathologies of major depressive disorder (MDD). However, underlying mechanisms has yet to be fully clarified. We previously established novel combined magnetic stimulation system treatment (c-MSST), which superparamagnetic iron oxide (SPIO) nanoparticles were accurately microinjected left prelimbic (PrL) under pulsed electromagnetic fields, displayed antidepressant effect mice. Therefore, we further explore...