A5101868000- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- Photodynamic Therapy Research Studies
- Immunotherapy and Immune Responses
- Medicinal Plants and Neuroprotection
- Cancer Research and Treatments
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Ultrasound Imaging and Elastography
- Luminescence and Fluorescent Materials
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Electrospun Nanofibers in Biomedical Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Thyroid Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Immune cells in cancer
- Renal and related cancers
Zhongnan Hospital of Wuhan University
2018-2024
Wuhan University
2018-2024
Ocean University of China
2023
Chongqing Medical University
2019
Chinese PLA General Hospital
2017-2018
Nankai University
2017-2018
The Forkhead box M1 (FoxM1) transcription factor is an important anti-tumor target. A novel targeted ultrasound (US)-sensitive nanobubble that likely to make use of the physical energy US exposure for improvement delivery efficacy target tumors and specifically silence FoxM1 expression appears as among most potential nanocarriers in respect drug delivery. In this study, we synthesized a promising siRNA-loaded cationic nanobubbles (CNBs) conjugated with A10-3.2 aptamer (siFoxM1-Apt-CNBs),...
Objective: Prepare a multifunctional ultrasound molecular probe, hyaluronic acid-mediated cell-penetrating peptide-modified 10-hydroxycamptothecin-loaded phase-transformation lipid nanoparticles (HA/CPPs-10-HCPT-NPs), and to combine HA/CPPs-10-HCPT-NPs with low-intensity focused (LIFU) for precision theranostics against hepatocellular carcinoma (HCC). Methods: were prepared using thin-film dispersion, emulsification, electrostatic effects. characterized particle size, zeta potential,...
The complex genomics, immunosuppressive tumor microenvironment (TME), and chemotherapeutic resistance of osteosarcoma (OS) have resulted in limited therapeutic effects the clinic. Ferroptosis is involved progression regulated mainly by glutathione peroxidase 4 (GPX4). Small interfering RNA (siRNA)-based interference (RNAi) can precisely target any gene. However, achieving effective siRNA delivery highly challenging. Here, we fabricated a TME-responsive metal-organic framework (MOF)-based...
Abstract: In the current study, we synthesized prostate cancer-targeting poly(lactide- co -glycolic acid) (PLGA) nanobubbles (NBs) modified using A10-3.2 aptamers targeted to prostate-specific membrane antigen (PSMA) and encapsulated paclitaxel (PTX). We also investigated their impact on ultrasound (US) imaging therapy of cancer. PTX-A10-3.2-PLGA NBs were developed water-in-oil-in-water (water/oil/water) double emulsion carbodiimide chemistry approaches. Fluorescence together with flow...
One key challenge in postoperative glioblastoma immunotherapy is to guarantee a potent and durable T-cell response, which restricted by the immunosuppressive microenvironment within lymph nodes (LNs). Here, we develop an situ sprayed exosome-cross-linked gel that acts as artificial LN structure directly activate tumor-infiltrating T cells for prevention of glioma recurrence. Briefly, this generated bio-orthogonal reaction between azide-modified chimeric exosomes alkyne-modified alginate...
Background and purpose: Surgery is regarded as the gold standard for patients with advanced ovarian cancer. However, complete surgical removal of tumors remains extremely challenging; fewer than 40% are cured. Here, we developed a new modality theranostics cancer based on near-infrared light-triggered nanoparticle. Methods: Nanoparticles loading IR780 iodide base folate modified liposomes were prepared used Tumor targeting FA-IR780-NP was evaluated in vitro an xenograft tumor model. A...
Aggregation-induced emission luminogens (AIEgens) exhibit potent sonosensitivity in nanocarriers compared with conventional organic sonosensitizers owing to the strong fluorescence aggregated state. However, premature drug leakage and ineffective tumor targeting of current AIE nanosonosensitizers critically restrict their clinical applications. Here, an AIEgen-based sonosensitizer (AIE/Biotin-M) excellent was developed by assembling salicylaldazine-based amphiphilic polymers (AIE-1) 4T1...
Prepare a multifunctional ultrasound molecular probe, cell-penetrating peptide-modified 10-hydroxycamptothecin-loaded phase-transformation lipid nanoparticles (iRGD-ICG-10-HCPT-PFP-NPs), and to combine iRGD-ICG-10-HCPT-PFP -NPs with low-intensity focused (LIFU) for precision theranostics against hepatocellular carcinoma (HCC).The morphology of (NPs) iRGD-ICG-10-HCPT-PFP-NPs was detected. In vitro, we examined targeting ability by flow cytometry confocal laser scanning microscopy (CLSM),...
Precise targeted delivery of therapeutic agents is crucial for tumor therapy. As an emerging fashion, cell-based provides better biocompatibility and lower immunogenicity enables a more precise accumulation drugs in cells. In this study, novel engineering platelet was constructed through cell membrane fusion with synthesized glycolipid molecule, DSPE-PEG-Glucose (DPG). The obtained glucose-decorated platelets (DPG-PLs) maintained their resting state structural functional integrities, while...
Abstract Background Accumulation of tau oligomers at the synapses in Alzheimer’s disease (AD) disrupts neuronal activities and leads to neurodegeneration. Tau immunotherapy has been actively pursued as a treatment for tauopathies past decade. Despite several failed Phase 2 trials N‐terminus binding antibodies variety epitopes are being investigated different stages clinical trials. APNmAb005 is humanized monoclonal antibody designed block synaptic toxicity elicited by oligomers. Method was...
Theranostic perfluorocarbon nanoprobes have recently attracted attention due to their fascinating versatility in integrating diagnostics and therapeutics into a single system. Furthermore, although 17β-estradiol (E2) is potential anti-hypertrophic drug, it has severe non-specific adverse effects various organs. Therefore, we developed cardiomyocyte-targeted theranostic achieve concurrent targeted imaging treatment of cardiac hypertrophy.We had successfully synthesized E2-loaded, primary...
Photothermal therapy (PTT) has great potential application in the treatment of tumors. However, due to low penetration near-infrared light (NIR) and concentration nanomaterials tumor site, PTT been limited.The objective this study was investigate therapeutic effect transcatheter intra-arterial infusion lecithin-modified Bi nanoparticles (Bi-Ln NPs) combined with interventional (IPTT) on hepatocellular carcinoma.Bi-Ln NPs were prepared by emulsifying hydrophobic lecithin, photothermal...
Abstract Background: Aggregation-induced emission luminogens (AIEgens) exhibit potent sonosensitivity in nanocarriers compared with conventional organic sonosensitizers owing to the strong fluorescence aggregated state. However, premature drug leakage and ineffective tumor targeting of current AIE nanosonosensitizers critically restrict their clinical application. Results: Here, an AIEgens-based sonosensitizer (AIE/Biotin-M) excellent was developed by assembling salicylaldazine-based...