A5009031026- Spinal Cord Injury Research
- Functional Brain Connectivity Studies
- Acupuncture Treatment Research Studies
- Nerve injury and regeneration
- Dementia and Cognitive Impairment Research
- Pregnancy-related medical research
- Alzheimer's disease research and treatments
- Neural dynamics and brain function
- Antibiotic Resistance in Bacteria
- Peroxisome Proliferator-Activated Receptors
- Neuroscience and Neural Engineering
- Pain Management and Placebo Effect
- Neonatal and fetal brain pathology
- Facial Nerve Paralysis Treatment and Research
- Enterobacteriaceae and Cronobacter Research
- Advanced Neuroimaging Techniques and Applications
- Genomics, phytochemicals, and oxidative stress
- Amyotrophic Lateral Sclerosis Research
- Transcranial Magnetic Stimulation Studies
- Tissue Engineering and Regenerative Medicine
- Kruppel-like factors research
- Cancer, Lipids, and Metabolism
- Autoimmune and Inflammatory Disorders Research
- Migraine and Headache Studies
- Inflammatory Myopathies and Dermatomyositis
Shanghai Children's Hospital
2021-2025
Shanghai Jiao Tong University
2021-2025
Zhongda Hospital Southeast University
2008-2023
The University of Texas Health Science Center at San Antonio
2019
Wenzhou Medical University
2017
Nanjing Drum Tower Hospital
2012-2016
Affiliated Hospital of Hebei University
2015
Nanjing University of Chinese Medicine
2014
Southeast University
2014
Air Force Medical University
2014
BackgroundCurcumin, a polyphenolic compound extracted from the plant turmeric, has protective effects on spinal cord injury (SCI) through attenuation of inflammatory response. This study was designed to detect whether curcumin modulates toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) signaling pathway in injured rat following SCI.MethodsAdult male Sprague–Dawley rats were subjected laminectomy at T8–T9 compression with vascular clip. There three groups: (a) sham group; (b) SCI...
Background: The early progression continuum of Alzheimer's disease (AD) has been considered to advance through subjective cognitive decline (SCD), non-amnestic mild impairment (naMCI), and amnestic (aMCI). Altered functional connectivity (FC) in the default mode network (DMN) is regarded as a hallmark AD. Furthermore, DMN can be divided into two subnetworks, anterior posterior subnetworks. However, little known about distinct disruptive patterns subsystems across preclinical AD spectrum....
Corticofugal influences on the responses of 39 ventrobasal (VB) thalamic neurons to repetitive stimuli were studied in awake rats by focally suppressing evoked and spontaneous electrocortical activity primary (S1) somatosensory cortex with magnesium or lidocaine plus magnesium. Suppression S1 reduced number spikes discharged 19 (66%) 29 VB units response each 25 electrical delivered medial lemniscus; 9 unaffected 1 showed an increased 1–10 Hz stimuli. The 6 (38%) 16 somatic also following...
KL1, KL2 CR-hvKP and KL64, KL47 hv-CRKP all exhibit overlapping multidrug resistance hypervirulence phenotypes, but the differences in epidemiological, phenotypic genotypic characteristics between them remains unclear. In this study, we collected non-repeated hv-CRKP/CR-hvKP isolates a tertiary hospital Shanghai, China from January 2019 to December 2022. Furthermore, selected four typical hypervirulent carbapenem-resistant Klebsiella pneumoniae, including ST23-KL1/ST86-KL2 (WYKP3 WYKP194)...
Insulin resistance represents one of the mechanisms underlying link between type 2 diabetes (T2D) and Alzheimer's disease (AD), we explored its in vivo neurobiology related to cognition based on a pathway-based genetic association analyses. Eighty-seven mild cognitive impairment (MCIs) subjects 135 matched controls (HCs) were employed at baseline, they underwent functional MRI scans, clinical evaluations exon sequencings 20 genes brain insulin resistance. A longitudinal study for an average...
The convergence of carbapenem-resistance and hypervirulence in Klebsiella pneumoniae has led to a significant public health challenge. In recent years, there have been more reports on carbapenem-resistant hypervirulent (CR-hvKP) isolates.Clinical data patients infected with CR-hvKP from January 2019 December 2020 tertiary hospital were retrospectively evaluated. number isolates pneumoniae, hypermucoviscous (hmKP), (CR-hmKP) collected during the period 2 years was calculated. antimicrobial...
Hypervirulent carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) has recently aroused an extremely severe health challenge and public concern. However, the underlying mechanisms of fitness costs that accompany antibiotic resistance acquisition remain largely unexplored. Here, we report a hv-CRKP-associated fatal infection reveal reduction in virulence due to aminoglycoside resistance.The bacterial identification, antimicrobial susceptibility, hypermucoviscosity, factors, MLST serotypes...
Corticofugal influences on the responses of ventrobasal (VB) thalamic neurons to repetitive stimuli were studied in anesthetized rats by suppressing primary somatosensory (S1) electrocortical activity with topically applied lidocaine. Effective concentrations lidocaine confined S1 and immediately adjacent cortex suppressed evoked corticofugal discharges. Suppression reduced average number spikes discharged 83 VB response each 25 electrical somatic delivered at frequencies ranging from 1 50...
// Baoyu Yuan 1 , Jiu Chen Liang Gong Hao Shu Wenxiang Liao Zan Wang Duan Liu Chunming Xie and Zhijun Zhang Department of Neurology, ZhongDa Hospital, Neuropsychiatric Institute, Medical School Southeast University, Nanjing, PR China Correspondence to: Zhang, email: Xie, Keywords : amnestic mild cognitive impairment (aMCI), executive function (EF), episodic memory (EM), regional homogeneity (ReHo), functional magnetic resonance imaging (fMRI), Pathology Section Received January 25, 2016...
Gray matter (GM) atrophy and disrupted intrinsic functional connectivity (IFC) are often present in patients with amnestic mild cognitive impairment (aMCI), which shows high risk of developing into Alzheimer's disease. Little is known, however, about the relationship between GM altered IFC, whether they related to decline.A total 30 aMCI 26 cognitively normal (CN) subjects were recruited for this study. Optimized voxel-based morphometric resting-state magnetic resonance imaging approaches...
BACKGROUND Erythropoietin has demonstrated neuroprotective effects against traumatic spinal cord injury (SCI), but the underlying mechanisms remain unclear. The signaling pathway of an antioxidant transcription factor, nuclear factor erythroid 2–related 2 (Nrf2), been shown to play important role in protecting SCI-induced secondary damage. This study was undertaken explore effect recombinant human erythropoietin (rhEPO) on activation Nrf2 and damage rats after SCI. METHODS Adult male...
Background: The apolipoprotein E (APOE) ɛ4 carriers are at increased risk of developing Alzheimer's disease (AD) while the ɛ2 appear to be protected against disease. default mode network (DMN), based in ventromedial prefrontal cortex (vmPFC) and posterior cingulate (PCC), co nsists functionally differentiable anterior subnetworks. Objective: This study was investigate whether there differential effects APOE polymorphisms on DMN subnetworks amnestic mild cognitive impairment (aMCI). Methods:...
To investigate the effects of ganglioside [monostalotetra-hexosylganglioside (GM1)] on expressions caspase-3 and nerve growth factor (NGF) in rats with acute spinal cord injury (SCI).Male Sprague- Dawley (SD) were selected randomly divided into Sham group, SCI group GM1 administration group. The subjected to behavioral examinations Basso Beattie Bresnahan (BBB) oblique-plate test at 1, 7 14 d after operation. content methylene dioxyamphetamine (MDA) activity superoxide dismutase (SOD) every...
The aim of the study was to investigate cognitive significance changes in default mode network (DMN) during process Alzheimer’s disease (AD) and genetic basis that drives alteration. Eighty-seven subjects with mild impairment (MCI) 131 healthy controls (HC) were employed at baseline, they had risk scores (GRS) based on GWAS-validated AD-related top loci. Eleven MCIs who converted AD (c-MCIs), 32 remained stable (nc-MCIs), 56 HCs participated follow-up analyses after an average 35 months....
Abstract Background Variation in genes implicated homocysteine and lipid metabolism systems may influence antidepressant response for patients with major depressive disorder (MDD). This study aimed to investigate whether association of polymorphisms on the MTHFR , ApoE ApoA4 treatment MDD subjects. Methods A total 281 Han Chinese received a single drug (SSRI or SNRI) at least 6 weeks, among whom 275 were followed up 8 weeks. Their weeks’ remission drugs was determined by changes 17-item...