A5067536950- Attention Deficit Hyperactivity Disorder
- Analytical Methods in Pharmaceuticals
- HIV/AIDS drug development and treatment
- Diabetes Treatment and Management
- Chemical and Physical Properties in Aqueous Solutions
- HIV Research and Treatment
- Bipolar Disorder and Treatment
- Ionic liquids properties and applications
- Crystallization and Solubility Studies
- Analytical Chemistry and Chromatography
- Pharmacological Effects and Toxicity Studies
- Metabolism, Diabetes, and Cancer
- Pharmacogenetics and Drug Metabolism
- Electrochemical Analysis and Applications
- Metabolomics and Mass Spectrometry Studies
- Mass Spectrometry Techniques and Applications
- Pesticide Residue Analysis and Safety
- Analytical chemistry methods development
- Proteoglycans and glycosaminoglycans research
- Child and Adolescent Psychosocial and Emotional Development
- Antibiotics Pharmacokinetics and Efficacy
- HIV/AIDS Research and Interventions
- Cancer Risks and Factors
- Genetics and Neurodevelopmental Disorders
- Traditional Chinese Medicine Analysis
Qilu Hospital of Shandong University
2024
Qingdao University
2024
Shandong University
2009-2024
Shandong Academy of Agricultural Sciences
2023
Poultry Research Institute
2023
Dezhou University
2019-2021
Xijing Hospital
2021
Bristol-Myers Squibb (United States)
2009-2020
ZheJiang Institute For Food and Drug Control
2020
University of Florida
2009-2020
Attention-deficit/hyperactivity disorder (ADHD) is a common heritable childhood behavioral disorder. Identifying risk factors for ADHD may lead to improved intervention and prevention. The dopamine transporter gene (DAT1) associated with in several studies, an average 1.2 odds ratio evidence of heterogeneity across data sets.To investigate sources by refining the DAT1 association using additional markers investigating gene-environment interaction between maternal use alcohol tobacco during...
Binodal data for the ethanol/1-propanol/2-propanol + ammonium sulfate water systems were determined at 298.15 K. On basis of an empirical equation and lever rule, liquid−liquid equilibrium compositions ethanol system directly calculated by Matlab. The Othmer−Tobias Bancroft proved reliability calculation method corresponding tie-line data. phase-separation abilities hydrophilic alcohols compared effective excluded volume (EEV) salt binodal curves plotted in molality. investigated are order...
Liquid−liquid equilibria (LLE) for the aqueous 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF4) + kosmotropic salt (Na3PO4, Na2CO3, Na2SO4, NaH2PO4, NaCl) systems have been determined experimentally at T= 298.15 K and in part T = (313.15 to 333.15) K. The binodal curves are fitted an empirical nonlinear expression developed by Merchuk, tie lines were described Othmer−Tobias Bancroft equations. Factors affecting such as salts temperature also studied. It was found that salting-out...
To determine the absolute oral bioavailability (F(p.o.) ) of saxagliptin and dapagliflozin using simultaneous intravenous ¹⁴C-microdose/therapeutic dosing (i.v.micro + oraltherap).The F(p.o.) values were determined in healthy subjects (n = 7 8, respectively) following concomitant administration single i.v. micro doses with unlabelled oraltherap doses. Accelerator mass spectrometry liquid chromatography-tandem used to quantify labelled drug, respectively.The geometric mean point estimates...
Abstract It has been widely postulated that the categorical diagnosis of attention deficit hyperactivity disorder (ADHD) should be seen as extreme end a set traits quantitatively distributed in general population. A consequence this is genes associated with DSM‐IV ADHD also influence these underlying non‐affected individuals. The aim study was to examine if specific candidate loci previously shown ADHD, act quantitative trait (QTLs) for ADHD‐symptoms We have genotyped five markers...
Background: Dapagliflozin is an inhibitor of sodium-glucose co-transporter 2 (SGLT-2) in development for the treatment Type diabetes. To support toxicology studies, LC–MS/MS methods were developed and validated quantitation dapagliflozin rat plasma. Results: The assay uses solid phase extraction analysis negative ion electrospray ionization mode. Because readily forms adducts presence formic acid, mobile phases simple mixtures water acetonitrile. was concentration range 5–2000 ng/ml with...
Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable of childhood characterized by inattention, impulsivity. Molecular genetic pharmacological studies suggest the involvement dopaminergic, serotonergic noradrenergic neurotransmitter systems in pathogenesis ADHD. Monoamine oxidase A (MAO-A) encodes an enzyme that degrades biogenic amines, including neurotransmitters such as norepinephrine, dopamine serotonin. In this study we examined 30 bp promoter variable number...
Abstract Background: Despite a considerable number of studies describing the relationship between area-level socioeconomic conditions and mammography screening, definitive conclusions have yet to be drawn. The aim this study was examine position (SEP) repeat using nationwide U.S. census SEP data linked nationally representative sample women who participated in 2005 National Health Interview Survey (NHIS). Methods: An index 2000 tract constructed categorized into quartiles, including...
Background Difficulties with performance and brain activity related to attentional orienting (Cue‐P3), cognitive or response preparation (Cue‐ CNV ) inhibitory control (Nogo‐P3) during tasks tapping executive functions are familial in ADHD may represent endophenotypes. The aim of this study was clarify the impact dopamine receptor D4 ( DRD 4) transporter DAT 1) gene polymorphisms on these processes children. Methods Behavioural electrophysiological parameters from cued continuous tests low...
Voriconazole, a broad-spectrum triazole antifungal agent, is metabolized by cytochrome P450 (CYP) 2C19 and, to lesser extent, CYP3A. Genetic polymorphism of CYP2C19 not only plays prominent role in its disposition but may also influence potential drug interactions with CYP450 modulators such as ritonavir. This study assessed 2-way voriconazole added on ritonavir-boosted atazanavir both extensive-metabolizer (EM) and poor-metabolizer (PM) healthy subjects. Each subject received alone days...
Clostridium perfringens is an important foodborne pathogen that can have severe consequences, including mortality and economic losses. In this study, the gene encoding cpp-lys, endolysin from C. phage cpp has been cloned overexpressed. The encoded protein was characterized, then its efficacy in controlling on lettuce evaluated. cpp-lys presented lytic activity against seven strains of produce different types toxins. It maintained stability across a wide range temperatures (4 °C - 50 °C),...
Maternal smoking during pregnancy is a risk factor for attention-deficit/hyperactivity disorder (ADHD), but data on its adverse effects cognitive functioning are sparse and inconsistent. Since the effect of maternal may be due to correlated genetic factors rather than being pure environmental effect, we examined prenatal exposure attentional control, taking into account both paternal smoking, whether these were genetically mediated by parental genotypes. We further control interacted with...
Atazanavir, a potent protease inhibitor of human immunodeficiency virus (HIV), exhibits pH-dependent solubility. Previous studies have indicated that coadministration with omeprazole 40 mg once daily significantly decreased atazanavir exposure by approximately 75%. Concomitant use and is currently not recommended. This study investigated clinically effective, low dose (20 daily) on pharmacokinetics in 56 healthy volunteers given atazanavir/ritonavir 300/100 400/100 daily. All plus...