A5102935971- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Renal and related cancers
- Intestinal Malrotation and Obstruction Disorders
- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Congenital Heart Disease Studies
- Congenital Anomalies and Fetal Surgery
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
- Neuroblastoma Research and Treatments
- Bone Tumor Diagnosis and Treatments
- Vascular Malformations and Hemangiomas
- Hip disorders and treatments
- Fetal and Pediatric Neurological Disorders
- Sarcoma Diagnosis and Treatment
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- Adrenal and Paraganglionic Tumors
- Tumors and Oncological Cases
- Esophageal and GI Pathology
- Histiocytic Disorders and Treatments
- Soft tissue tumor case studies
- Medical Imaging and Pathology Studies
- Testicular diseases and treatments
Nationwide Children's Hospital
2024
American Institute for Economic Research
2012-2021
Uniformed Services University of the Health Sciences
2009-2018
University of Florida
2017
Reckitt Benckiser (United States)
2017
Columbus Oncology and Hematology Associates
2017
Walter Reed National Military Medical Center
2014-2016
Bristol-Myers Squibb (United States)
2010-2016
Bristol-Myers Squibb (Germany)
2010-2013
Walter Reed Army Institute of Research
2000-2012
Malignant primary hepatic tumors in children include lesions unique to the pediatric age group and others that are more common adults. Important considerations when evaluating a child with liver tumor of patient, laboratory findings, specific imaging features. The most malignant population, hepatoblastoma occurs almost exclusively patients younger than 5 years no history disease. Hepatoblastoma is associated elevated serum α-fetoprotein (AFP) level appears predominantly solid. Hepatocellular...
The combination of peginterferon and ribavirin with telaprevir or boceprevir is the standard treatment hepatitis C virus (HCV) genotype 1 infection. However, these drugs are not well tolerated because their side effects suboptimal virologic responses. In a phase 2a, open-label study, we examined safety efficacy an interferon-free, ribavirin-free regimen direct-acting antivirals, comprising daclatasvir (an NS5A replication complex inhibitor), asunaprevir NS3 protease BMS-791325 (a...
Abstract The antiviral activity, resistance profile, pharmacokinetics (PK), safety, and tolerability of BMS-790052, a nonstructural protein 5A (NS5A) replication complex inhibitor, were evaluated in double-blind, placebo-controlled, sequential panel, multiple ascending dose study. Thirty patients with chronic hepatitis C virus (HCV) genotype 1 infection randomized to receive 14-day course BMS-790052 (1, 10, 30, 60, or 100 mg once daily 30 twice daily) placebo ratio 4:1. mean maximum decline...
Benign hepatic tumors in children include lesions that are unique to the pediatric age group and others more common adults. Infantile hemangioendothelioma, or infantile hemangioma, is a benign vascular tumor may cause serious clinical complications. It composed of channels lined by endothelial cells. At imaging, large feeding arteries draining veins early, intense, peripheral nodular enhancement with centripetal filling on delayed images characteristic features. Mesenchymal hamartoma liver...
Osteonecrosis is common and represents loss of blood supply to a region bone. Common sites affected include the femoral head, humeral knee, femoral/tibial metadiaphysis, scaphoid, lunate, talus. Symptomatic head osteonecrosis accounts for 10,000–20,000 new cases annually in United States. In contradistinction, metadiaphyseal often occult asymptomatic. There are numerous causes most commonly related trauma, corticosteroids, idiopathic. Imaging frequently diagnostic with serpentine rim...
Objective Our objective was to compare simvastatin with the validated probe midazolam in assessment of cytochrome P450 (CYP) 3A activity. Methods This study used an open-label, fixed-sequential, 3-way crossover design. Nineteen subjects received oral doses 0.075 mg/kg and 40 mg during 3 phases (baseline, after inhibition 400 ketoconazole for 10 days, induction 600 rifampin [INN, rifampicin] 9 days). Serial plasma concentrations were obtained. Oral clearances compared. Results clearance...
Precocious puberty represents a unique diagnostic problem in which imaging plays an important role. Development of secondary sex characteristics may result from inappropriate activation the hypothalamic-pituitary axis with release gonadotropin, or gonadotropin-independent secretion steroids by adrenal glands gonads. A variety lesions can manifest precocious puberty, including various central nervous system (CNS) lesions, and cord–stromal tumors testis ovary. CNS causing are much more common...
Intraperitoneal solid tumors are far less common in children than adults, and the histologic spectrum of neoplasms peritoneum its specialized folds young patients differs from that older patients. Localized masses may be caused by inflammatory myofibroblastic tumor, Castleman disease, mesenteric fibromatosis, or other mesenchymal masses. Inflammatory tumor is a borderline biologic potential appears as solitary circumscribed mass, possibly with central calcification. disease an idiopathic...
Voriconazole, a broad-spectrum triazole antifungal agent, is metabolized by cytochrome P450 (CYP) 2C19 and, to lesser extent, CYP3A. Genetic polymorphism of CYP2C19 not only plays prominent role in its disposition but may also influence potential drug interactions with CYP450 modulators such as ritonavir. This study assessed 2-way voriconazole added on ritonavir-boosted atazanavir both extensive-metabolizer (EM) and poor-metabolizer (PM) healthy subjects. Each subject received alone days...
Most pediatric masses in the chest are located mediastinum. These often initially detected incidentally on radiographs asymptomatic children, although some patients may present with respiratory symptoms. At radiography, mediastinum has been anatomically divided into anterior, middle, and posterior compartments. However, International Thymic Malignancy Interest Group classification scheme, which is based cross-sectional imaging findings, prevascular, visceral, paravertebral In prevascular...
Background Coadministration of oral contraceptives with protease inhibitors is complicated by drug interactions. An open-label three-period single-sequence study assessed the effect coadministration atazanavir (ATV)/ritonavir (RTV) Ortho Tri-Cyclen® and Tri- Cyclen® LO (Ortho-McNeil-Janssen Pharmaceuticals, Inc., Raritan, NJ, USA) on pharmacokinetics (PK) ethinyl estradiol (EE), norgestimate (NGM), ATV RTV. Methods A total 20 healthy women aged 18–45 years received treatments. In lead-in...
Study Objective To investigate the pharmacokinetic and pharmacodynamic relationships of human immunodeficiency virus (HIV) –protease inhibitor atazanavir ( ATV ) in presence absence booster ritonavir, utilizing plasma trough concentrations (C clinical biomarkers antiviral efficacy safety over 48 weeks. Design Randomized, open‐label, multicenter, study designed to compare 300 mg plus ritonavir 100 300/r) with that 400 400). Setting Thirty clinic sites across 10 countries Africa, Europe, North...