A5100406271- Innovative Microfluidic and Catalytic Techniques Innovation
- Monoclonal and Polyclonal Antibodies Research
- Microfluidic and Capillary Electrophoresis Applications
- Hydrocarbon exploration and reservoir analysis
- Nanoplatforms for cancer theranostics
- Drilling and Well Engineering
- Cardiovascular and Diving-Related Complications
- Hydraulic Fracturing and Reservoir Analysis
- Radiation Therapy and Dosimetry
- Evacuation and Crowd Dynamics
- Hearing, Cochlea, Tinnitus, Genetics
- Insect behavior and control techniques
- Nicotinic Acetylcholine Receptors Study
- vaccines and immunoinformatics approaches
- Coal Properties and Utilization
- Engineering Applied Research
- Fluid Dynamics and Heat Transfer
- Fluid Dynamics and Mixing
- Insect and Pesticide Research
- Nanoparticle-Based Drug Delivery
- Heat Transfer and Boiling Studies
- Insect Pheromone Research and Control
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Advanced Optical Network Technologies
Nanjing University of Chinese Medicine
2024-2025
Huazhong Agricultural University
2023
Baker Hughes (United States)
2022
Chongqing University of Posts and Telecommunications
2022
Shanghai Power Equipment Research Institute
2020
Wuhan National Laboratory for Optoelectronics
2019
Huazhong University of Science and Technology
2019
University of Chinese Academy of Sciences
2019
ShanghaiTech University
2017
China Huadian Corporation (China)
2017
Abstract COVID-19 pandemic caused by SARS-CoV-2 constitutes a global public health crisis with enormous economic consequences. Monoclonal antibodies against can provide an important treatment option to fight COVID-19, especially for the most vulnerable populations. In this work, potent binding Spike protein were identified from convalescent patients. Among them, P4A1 interacts directly and covers majority of Receptor Binding Motif Receptor-Binding Domain, shown high-resolution complex...
Microfluidics system enables high-throughput functional screening of antibodies for cancer immunotherapy.
With the characteristics of low-latency, seamless coverage and high bandwidth, Low Earth Orbit (LEO) satellite network has been promising technology for sixth-generation mobile communication (6 G) networks, especially, inter-satellite link can improve flexibility networking routing. However, in existing works, since impact attributes on topology not well investigated, it is difficult to avoid loss information transmission path selection, which may aggravate unreliability routing path. In...
Platinum-based anticancer drugs exert their effects by forming adducts within nuclear DNA (nDNA), inhibiting transcription and inducing apoptosis in cancer cells. However, tumor cells have evolved mechanisms to resist these drugs. Given mitochondria's role lack of nucleotide excision repair (NER), targeting mitochondrial (mtDNA) offers a strategy. Herein, platinum-based terminal-sensitive projectile (TSB) which comprises heterofunctional tetravalent platinum prodrug as the primary warhead,...
The mechanism of dynamic wetting and the fluid dynamics during onset droplet mobilization driven by a microchannel flow are not clearly understood. In this work, we use microparticle tracking velocimetry to visualize velocity distribution inside both prior mobilization. Time-averaged instantaneous vectors determined using fluorescent microscopy for various capillary numbers. A circulating exists at subcritical number, in which case is pinned channel walls. When number exceeds critical value,...
Background: Mutations leading to changes in properties, regulation or expression of connexin–made channels have been implicated twenty-eight distinct human hereditary diseases. Eight these result from variants connexin 26 (Cx26), a protein critically involved cell-cell signaling the inner ear and skin. Lack non-toxic drugs with defined mechanisms action poses serious obstacle therapeutic interventions for diseases caused by mutant connexins. In particular, molecules that specifically...
There are various types of pores in shale, mainly consisting nanopores and micropores, causing flow regime variations apparent permeability changes during the development reservoir. In this paper, a Knudsen number calculation model is proposed with actual conditions gas shale Then, based on distribution an established using hydrodynamics, method put forward for Finally, correction coefficient used to analyze coefficients Results show that decreasing pressure, increases, from continuous slip...
Abstract BACKGROUND Bactrocera minax is a devastating pest of citrus fruits. However, there have been no effective control measures before. Few reports on the sex pheromones B. are available. RESULTS In this study, nine volatile compounds in adult females were identified using headspace solid‐phase microextraction (HS‐SPME) combination with gas chromatography–mass spectrometry (GC–MS). Among them, d‐limonene, caprolactam, 2‐Nitro‐1H‐imidazole, and creatinine could evoke antennal responses...
Abstract Colorectal cancer (CRC) stands out as one of the most prevalent gastrointestinal cancers. Current treatment strategies for CRC are significantly hindered by systemic toxicity and suboptimal therapeutic efficacy. This study aims to overcome these limitations developing a robust tumor‐targeting chemo‐photothermal strategy, combining Bortezomib (BTZ) proteasome inhibitor, IR780 iodide near‐infrared dye, Photothermal Therapy (PTT) agent, with hyaluronic acid (HA) serving shell tumor...
A numerical simulation study of Venturi overreading characteristics is carried out with Mixture model and Realizable k-e model, a prediction under low pressure conditions proposed. Compared the existing experimental data, it demonstrates that results have high accuracy, indicate quality main factor affecting Meanwhile, in this paper compared ten classical models such as homogeneous model. It shows average deviation 3.2%, ranking second, maximum 7.3%. This can provide reference for wet gas...
Abstract Currently high throughput approaches are lagged for isolation of antibodies whose function goes beyond simple binding, which have prevented the next generation cancer immunotherapeutics, such as bispecific T cell engager or agonist antibody costimulatory receptor, from reaching their full potential. Here we developed a highly efficient droplet-based microfluidics platform combining with lentivirus transduction system that enables functional screening millions antibodies. To showcase...
The energy consumption of the door closing process was decomposed into six subsystems, which include weight, hinge, checklink, latch, weather strip seal and airbinding effect. working principle each subsystem analysed then mathematical model in established, respectively. calculated programmatically via an Excelbased software using VBA programming language. different subsystems a production vehicle measured to verify accuracy calculation developed. proposed research provided not only...
Compared with unidirectional and bi-directional pedestrian flow, multi-directional flow exhibit complex moving patterns, thus is more confusing for studying. In this research, an extended cell transmission model developed simulating crossing flows in area multiple exits. The innovations of are reflected the potential field algorithm considering congestion computed on whole crowd area, taking difference exit widths emotion into as a set parameters. Through numerical simulations comparisons...
Abstract An accurate pore-pressure prediction plays an important role in well planning as exploration targets shift to deeper over-pressured reservoirs. Pore pressure related problems high-pressure high-temperature (HPHT) wells include control, lost circulation, formation breathing, differential sticking, reduced penetration rate, and reservoir damage, many of which can potentially lead expensive sidetracks, underground blowouts early abandonment. integrated approach help with better...