A5076674669- Monoclonal and Polyclonal Antibodies Research
- Microfluidic and Capillary Electrophoresis Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- CAR-T cell therapy research
- Robotic Mechanisms and Dynamics
- Click Chemistry and Applications
- Image and Object Detection Techniques
- Receptor Mechanisms and Signaling
- Transgenic Plants and Applications
- Immunotherapy and Immune Responses
- Protein purification and stability
- Advanced Surface Polishing Techniques
Nankai University
2020-2021
Hospital 463 People's Liberation Army
2019
Microfluidics system enables high-throughput functional screening of antibodies for cancer immunotherapy.
Fc engineering has become the focus of antibody drug development. The current mutagenesis and
Abstract Currently high throughput approaches are lagged for isolation of antibodies whose function goes beyond simple binding, which have prevented the next generation cancer immunotherapeutics, such as bispecific T cell engager or agonist antibody costimulatory receptor, from reaching their full potential. Here we developed a highly efficient droplet-based microfluidics platform combining with lentivirus transduction system that enables functional screening millions antibodies. To showcase...
Abstract Agonist OX40 antibodies have shown promising pre-clinical activities, but their clinical activities been limited thus far. Several reasons may account for this activity, including sub-optimal antibody design, dose selection, and lack of a biomarker strategy indication selection patient enrichment. Previous trials selected doses that maximized receptor occupancy, some patients responded at lower doses, indicating nuances to choosing the correct therapeutic an agonist antibody. In...
The new metal rubber blank automatic laying equipment solves the technical problem of preparing large-sized sheet components and component blanks with complicated configurations such as holes. Based on process rubber, are divided into simple configuration complex configuration, a method for judging feasible path is proposed. matlab, type rapid obstacle avoidance strategy was designed, which realized identification positioning laying, provided support planning laying.
Abstract Agonistic antibodies against the co-stimulatory receptor OX-40 have shown promising activity in preclinical models, but clinical has only been observed isolated cases. While co-stimulation of T cells is described as primary pharmacological mechanism these antibodies, high expression on tumor-infiltrating regulatory also and discussed a potentially confounding factor setting. We present HFB10-1E1, novel agonistic antibody with an optimized profile. HFB10-1E1 binds specifically to...