A5100416979- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Mast cells and histamine
- Synthetic Organic Chemistry Methods
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Vector-Borne Animal Diseases
- Viral Infections and Vectors
- SARS-CoV-2 detection and testing
- Catalytic C–H Functionalization Methods
- Food Allergy and Anaphylaxis Research
- Ion channel regulation and function
- PARP inhibition in cancer therapy
- Anesthesia and Neurotoxicity Research
- Synthesis and Biological Evaluation
- Mosquito-borne diseases and control
- CRISPR and Genetic Engineering
- Radiopharmaceutical Chemistry and Applications
- Biofuel production and bioconversion
- Anesthesia and Sedative Agents
- Chemical Synthesis and Analysis
- Intensive Care Unit Cognitive Disorders
- Structural Health Monitoring Techniques
- Meat and Animal Product Quality
- Neurotransmitter Receptor Influence on Behavior
Xi'an Jiaotong University
2011-2025
Gansu Agricultural University
2025
Shanghai Sixth People's Hospital
2024
Zhejiang Taizhou Hospital
2024
Wenzhou Medical University
2024
Shaoxing University
2024
South China University of Technology
2020-2024
Jiangnan University
2021-2024
Indiana University School of Medicine
2022
Indiana University – Purdue University Indianapolis
2022
Tick-borne viral diseases have attracted much attention in recent years because of their increasing incidence and threat to human health. Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV) Heartland virus (HRTV) were recently identified as tick-borne phleboviruses (TBPVs) Asia the United States, respectively, are associated severe similar clinical manifestations. In this study, we report first identification isolation a novel TBPV named Guertu (GTV) from Dermacentor nuttalli...
Coronavirus Disease 2019 (COVID-19) cases and deaths are still rising worldwide, there is currently no effective treatment for severe inflammation acute lung injury caused by new coronavirus (SARS-COV-2) infection. Therapies to prevent or treat COVID-19, including antiviral drug several vaccines, being development. Human angiotensin-converting enzyme 2 (ACE2), expressing in lung, has been confirmed be a receptor SARS-COV-2 infection, interventions attachment of spike protein SARS-CoV-2 ACE2...
We report herein an iron-catalyzed azidotrifluoromethylation method for expedient vicinal trifluoromethyl primary-amine synthesis. This is effective a broad range of olefins and N-heterocycles, it facilitates efficient synthesis wide variety primary amines, including those that prove difficult to synthesize with existing approaches. Our preliminary mechanistic studies revealed the catalyst-promoted azido-group transfer proceeds through carbo-radical instead carbocation species....
PARP inhibitors have highly significant effects on BRCA mutant cells, allowing targeted therapy of triple-negative breast cancer (TNBC). However, some TBNC patients lack mutations. Recent studies shown that EZH2 can increase the sensitivity wild-type cells to inhibitors. We designed a series dual and inhibitors, most promising compound, 5a, showed good inhibitory activity against PARP-1 MDA-MB-231 (IC50 = 2.63 μM) MDA-MB-468 0.41 with BRCA. Compared olaparib, growth activities these two cell...
Anaphylactoid reactions are common clinical acute adverse drug that can exacerbate a patient's condition and produce effects may become life-threatening. Therefore, it is important to establish novel method evaluate drugs for anaphylactoid reactions. In this study, we developed sensitive rapid detect histamine release from LAD2 cells using liquid chromatography-tandem mass spectrometry (LC-MS/MS) constructed relative index based on various curve parameters, including allergen time sudden...
Nucleocapsid (N) protein plays crucial roles in the life cycle of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including formation ribonucleoprotein (RNP) complex with viral RNA. Here we reported crystal structures N-terminal domain (NTD) and C-terminal (CTD) N an NTD-RNA complex. Our reveal a unique tetramer organization NTD identify distinct RNA binding mode complex, which could contribute to RNP We also screened small molecule inhibitors N-NTD N-CTD discovered that...
Abstract This study presents a protocol for the direct site‐selective difunctionalization of pyrazoles under mild reaction conditions. showcase notable site‐selectivity and encompasses wide substrate scope. Detailed mechanistic investigations elucidate dual role sulfonium salt acting both as acid donor, thereby effectively catalyzing reaction. The demonstrated one‐pot synthesis, scale‐up subsequent product modifications can assist in advancing potential application this organic synthesis its...
Mas-related G protein-coupled receptor X2 (MrgX2) plays a key role in pseudoallergy reactions; thus, it is of great significance to screen compounds with antipseudoallergy activity via MrgX2. Cell membrane chromatography (CMC) demonstrates potential drug screening, but requires further optimization improve its specificity and stability. In this study, new CMC system incorporating His-tag-oriented immobilized proteins was constructed MrgX2 antagonists. Single His-tag-fused extracted intactly...
Abstract Fulvic acid (FA) has many physiological activities, but the specific metabolic responses and changes in mineral element contents of spinach by FA response to nitrate stress are unknown. Herein, we used liquid chromatography-mass spectrometry (LC–MS) wet digestion using H 2 SO 4 -H O analyze content (150 mM NO 3 − ) after (0.15%) foliar spray application. After days treatment, was sprayed thrice (once every 7 days), sampled last spraying, metabolites were measured. treatment...
The present study was designed to determine whether the sensitization of locomotor activity that results from chronic phencyclidine (PCP) administration is associated with altered NMDA receptor function or mRNA in rat brain. Female Sprague-Dawley rats were administered PCP (20 mg/kg, i.p.) once daily for 5 days. After withdrawal 72 hr, challenge 3.2 mg/kg (i.p.) revealed a significant activating effect PCP. In situ hybridization analysis an oligonucleotide probe complementary encoding NR1...
Phencyclidine (PCP) administration in rats acutely high doses or chronically lower causes neurotoxicity characterized by neuronal vacuolization and apoptotic death, respectively. The purpose of this study was to determine whether drugs that previously had been reported prevent either type were also able locomotor sensitization following chronic PCP administration. (5 20 mg/kg) administered once a day for 5 days drug pretreatment. After withdrawal, challenged with 3.2 mg/kg activity assessed....
Membrane protein (MP)-based biomaterials have a wide range of applications in drug screening, antigen detection, and ligand–receptor interaction analysis. Traditional MP immobilization methods the disadvantage disordered orientation, leading to shielded binding domain unreliable pattern. Herein, we describe site-specific covalent MPs, which utilizes styrene maleic acid (SMA) detergent-free extraction method MPs as well reaction between His-tag divinyl sulfone (DVS). As an example, covalently...
A highly effective enantioselective monobenzoylation of 1,3-diols has been developed for the synthesis 1,1-disubstituted tetrahydro-β-carbolines. The chemistry successfully applied to asymmetric total (+)-alstrostine G, which also features a cascade Heck/hemiamination reaction enabling facile construction pivotal pentacyclic core.
5-Hydroxymethylfurfural (5-HMF) and its acid-catalyzed oligomers can inhibit nerve cell proliferation induce neurological deficits at near or below the reported 24 h dietary intake of 5-HMF in humans.
Abstract Recently, the recurrence of positive SARS-CoV-2 viral RNA in recovered COVID-19 patients get more attention. Here we report a cohort study on follow up 182 under medical isolation observation. There are 20 (10.99 %) out were detected turned positive, but none them shows any clinical symptomatic indicating that has good prognosis. Females and young aged 15 have higher re-positive rate than average, severe re-positive. Notably, most cases turn negative followed tests, suggesting...