A5101793067- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- Signaling Pathways in Disease
- COVID-19 Clinical Research Studies
- Inflammatory mediators and NSAID effects
- Neonatal Respiratory Health Research
- Calpain Protease Function and Regulation
- Eicosanoids and Hypertension Pharmacology
- Inflammation biomarkers and pathways
- MicroRNA in disease regulation
- Pharmacological Effects of Natural Compounds
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- SARS-CoV-2 detection and testing
- Thermal Regulation in Medicine
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune cells in cancer
- Long-Term Effects of COVID-19
- Cancer-related molecular mechanisms research
Institute of High Energy Physics
2024
Shandong First Medical University
2020-2024
Shandong Provincial Hospital
2005-2024
Chinese Academy of Sciences
2024
Peking University
2023
Peking University First Hospital
2023
Shenzhen Genoimmune Medical Institute
2020-2022
Shandong University
2005-2020
Army Medical University
2008-2017
Xinqiao Hospital
2005-2017
Abstract Recently, the recurrence of positive SARS-CoV-2 viral RNA in recovered COVID-19 patients is receiving more attention. Herein we report a cohort study on follow-up 182 under medical isolation observation. Twenty (10.99%) out were detected to be (re-positives), although none showed any clinical symptomatic recurrence, indicating that responds well treatment. Patients aged 18 years had higher re-positive rates than average, and severely ill re-tested positive. There no significant...
Objective:The aim of this study was to observe the liver function recovery COVID-19 patients after discharge.Patients and Methods: A total 253 discharged in Shenzhen city, China were selected.The clinical characteristics these assessed.A 2-month follow-up laboratory hematology test performed examine status patients' function.Results: Patients combined with diseases, especially fatty liver, are more likely progress severe condition (P<0.05).Patients those diseases have higher rates injuries...
The Circular Electron Positron Collider (CEPC) is a large-scale scientific project proposed by the Chinese high-energy physics community. CEPC accelerator Technical Design Report (TDR) has been released in 2023. collider's energy scale ranges from Z-pole at 91 GeV to W$^{+}$W$^{-}$ 160 GeV, ZH 240 and up $t\bar{t}$ 360 GeV. It will be large Higgs Z factory allow precise measurements of their properties searches for new beyond Standard Model (SM). In updated CPEC Physics Detector Report,...
Objectives: Research on recovering COVID-19 patients could be helpful for containing the pandemic and developing vaccines, but we still do not know much about clinical features, recovery process, antibody reactions during period.Methods: We retrospectively analysed epidemiological information, discharge summaries, laboratory results of 324 patients.Results: In all, 15 (8.62%) experienced chest distress/breath shortness, where 8 were severely ill.This means ill need an extended amount time to...
Uncoupling protein 2 (UCP2) is upregulated in patients with systemic inflammation and infection, but its functional role unclear. We up- or downregulated UCP2 expression using recombinant adenovirus the inhibitor, genipin, lungs of mice, investigated mechanisms ALI. overexpression mouse increased LPS-induced pathological changes, lung permeability, inflammation, lowered survival rates. Furthermore, ATP levels mitochondrial membrane potential were decreased, while reactive oxygen species...
Intravitreal injection of anti-vascular endothelial growth factor is considered the first-line treatment for polypoidal choroidal vasculopathy. It has potential risks circulatory system, which should be particularly carefully evaluated in older patients. In this case study, we aim to discuss impact regimen on cardiac health. This report describes an elderly patient with no prior history heart disease who exhibited unexpected enlargement and dysfunction. Throughout patient's hospital stay,...
Abstract Recently, the recurrence of positive SARS-CoV-2 viral RNA in recovered COVID-19 patients get more attention. Here we report a cohort study on follow up 182 under medical isolation observation. There are 20 (10.99 %) out were detected turned positive, but none them shows any clinical symptomatic indicating that has good prognosis. Females and young aged 15 have higher re-positive rate than average, severe re-positive. Notably, most cases turn negative followed tests, suggesting...
Calpain, calcineurin (CaN), and nuclear factor of activated T cell (NFAT) play a key role in the development atrial fibrillation. Patients with valvular heart disease (VHD) are prone to develop fibrillation (AF). Thus, our current study was aimed at investigating whether activation calpain-CaN-NFAT pathway is associated incidence AF patients VHD diabetes. The expressions calpain 2 alpha- beta-isoforms CaN catalytic subunit (CnA) as well NFAT-c3 NFAT-c4 were quantified by quantitative reverse...
The calmodulin-independent pathway is thought to involve the activation of calcineurin by calpain. However, effect endogenous calpain on in human heart not well known.Proteolysis and recombinant purified isozymes I II as calpains were investigated Western blot. Activation was examined using zymography a activity assay.Calpains caused limited proteolysis full-length Ca(2+)-dependent manner, degradation fragment(s) constitutively active absence calmodulin. Calpain expressed ventricular...
Introduction: Rituximab is a monoclonal chimeric antibody against CD20+ B cells. We aimed to assess the long-term efficacy and safety of cell-guided treatment with low-dose rituximab in refractory myasthenia gravis patients. Methods: Patients treated for more than 2 years were included. was administered when cells greater 1%. analysed rituximab, interval, side effects, prognosis, course. Results: A total 22 patients All received 2–12 doses median follow-up time 48.5 months. The scores...
The calcineurin (CaN) enzyme–transcriptional pathway is critically involved in hypertrophy of heart muscle some animal models. Currently there no information concerning the regulation CaN activation by endogenous agonists human heart. Human right ventricular trabeculae from explanted (14 male/2 female) failing hearts were set up a tissue bath and electrically paced at 1 Hz incubated with or without 100 n M endothelin‐1 (ET‐1), 10 μ , angiotensin‐II (Ang II) 20 urotensin‐II (hUII) for 30 min....
Abstract The outbreak of Coronavirus Disease 2019 (COVID-19) is getting worse every day all over the world. present study aimed to review epidemiological characteristics patients infected with COVID-19 in Shenzhen city, a super megacity China, provide some references for fighting coronavirus. We collected data 417 laboratory-confirmed through March 7 th , 2020. were analyzed. Besides, we governmental measures and dynamic changes epidemic outbreak. Governmental strategies such as early...
Nerve growth factor (NGF) and tropomyosin kinase receptors A (TrKA) exert a crucial effect on the regulation of autonomic nervous system which contributes to progress atrial fibrillation (AF). Valvular heart disease (VHD) patients are more easily induce AF. We investigated whether NGF/TrKA could impact occurrence AF in VHD patients.Atrial tissues were resected from 30 with chronic (n = 15, >6 months) or sinus rhythm (SR, n 15). The expression NGF, TrKA, protein B (PKB/Akt), beta-isoforms...
Abstract Sinoporphyrin sodium (DVDMS) is a novel sensitizer discovered by Professor Fang Qi-Cheng and widely used in photodynamic (PDT) sonodynamic therapy (SDT). We searched databases including PubMed, Web of Science, CNKI, etc. for system review its progress. found that, both DVDMS-PDT -SDT had been proven effective inhibiting tumor growth mechanisms involved reactive oxygen species, autophagy, mitochondrial apoptosis pathways. Material advances enhanced antitumor effects expanded...